Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HEART FAILURE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | HEART FAILURE |
| Key Genes/Proteins | BIN1, SIRT3, APP, SIRT1, MMP2 |
| Related Diseases | TYPE 2 DIABETES, AGING, OXIDATIVE STRESS, CANCER, STROKE |
Knowledge base pages for this entity
graph TD
HEART_FAILURE["HEART FAILURE"]
HEART_FAILURE -->|"target for"| Immune_Response["Immune Response"]
HEART_FAILURE -->|"target for"| Epigenetic["Epigenetic"]
HEART_FAILURE -->|"inhibits"| Apoptosis["Apoptosis"]
HEART_FAILURE -->|"contributes to"| Oxidative_Stress["Oxidative Stress"]
HEART_FAILURE -->|"contributes to"| Autophagy["Autophagy"]
vagal_nerve_stimulation["vagal nerve stimulation"] -.protects against.-> HEART_FAILURE
pressure_overload["pressure overload"] -->|"causes"| HEART_FAILURE
altered_metabolic_activity["altered metabolic activity"] -->|"causes"| HEART_FAILURE
LETM1["LETM1"] -->|"target for"| HEART_FAILURE
MCU["MCU"] -->|"target for"| HEART_FAILURE
OVERVIEW["OVERVIEW"] -->|"target for"| HEART_FAILURE
ASXL1["ASXL1"] -->|"target for"| HEART_FAILURE
SF3B1["SF3B1"] -->|"target for"| HEART_FAILURE| Target | Relation | Type | Str |
|---|---|---|---|
| TYPE 2 DIABETES | stabilizes | disease | 0.65 |
| OXIDATIVE STRESS | stabilizes | phenotype | 0.60 |
| SIRT3 | associated_with | gene | 0.50 |
| APP | associated_with | gene | 0.50 |
| SIRT1 | associated_with | gene | 0.45 |
| MMP2 | associated_with | gene | 0.45 |
| BIN1 | associated_with | gene | 0.45 |
| CANCER | associated_with | disease | 0.44 |
| OXIDATIVE STRESS | interacts_with | process | 0.44 |
| INFLAMMATION | interacts_with | process | 0.44 |
| NEURODEGENERATION | implicated_in | process | 0.35 |
| STROKE | implicated_in | disease | 0.35 |
| MACROPHAGES | regulates | cell_type | 0.35 |
| MACROPHAGES | implicated_in | cell_type | 0.35 |
| MICROGLIA | implicated_in | cell_type | 0.35 |
| SIRT1 | regulates | gene | 0.35 |
| TGF-BETA | implicated_in | gene | 0.35 |
| MONOCYTES | causes | cell_type | 0.35 |
| SEMAGLUTIDE | regulates | drug | 0.35 |
| ALZHEIMER'S DISEASE | activates | disease | 0.30 |
| MICROGLIA | activates | cell_type | 0.30 |
| TP53 | regulates | gene | 0.30 |
| LIPID METABOLISM | regulates | process | 0.30 |
| SENESCENCE | implicated_in | process | 0.30 |
| ISCHEMIA | implicated_in | disease | 0.30 |
| AGING | implicated_in | process | 0.30 |
| AGING | interacts_with | process | 0.30 |
| SENESCENCE | interacts_with | process | 0.30 |
| FIBROSIS | regulates | disease | 0.30 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AGING | causes | phenotype | 0.65 |
| BIN1 | depleted_in | gene | 0.55 |
| DIABETES | implicated_in | disease | 0.35 |
| ENDOTHELIAL CELLS | causes | cell_type | 0.35 |
| ALZHEIMER'S DISEASE | implicated_in | disease | 0.35 |
| CARDIOMYOCYTES | activates | cell_type | 0.35 |
| C1Q | implicated_in | gene | 0.35 |
| ALZHEIMER'S DISEASE | regulates | disease | 0.30 |
| CANCER | regulates | disease | 0.30 |
| LIPID METABOLISM | causes | process | 0.30 |
| ATHEROSCLEROSIS | causes | disease | 0.30 |
| HYPERTENSION | causes | disease | 0.30 |
| CANCER | causes | disease | 0.30 |
| SENESCENCE | implicated_in | process | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||