gene

GAS6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAS6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

1Hypotheses

0Analyses

50Outgoing

39Incoming

Summary

GAS6 encodes the TAM receptor ligand GAS6, a vitamin K-dependent protein involved in cell survival, phagocytosis, and neuroprotection with roles in Alzheimer's, Parkinson's, and ALS

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🧬 Gene Info

Gene Symbol	GAS6
Full Name	Growth Arrest Specific 6
Chromosome	13q34
Function	is a multifunctional protein involved in cell survival, proliferation, migration, phagocytosis, and immunomodulation.
Pathways	Nf-Κb, Phagocytosis, Proteasome
UniProt ID	[P14384](https://www.uniprot.org/uniprot/P14384)
Ensembl ID	ENSG00000111321
OMIM	600441
GeneCards	GAS6
Human Protein Atlas	GAS6
Gla Domain	γ-carboxylated glutamic acid residues enable calcium-dependent membrane binding
Loop 1	Contains growth factor-like domain with receptor binding sites
Loop 2	Additional receptor interaction region
Loop 3	Heparin-binding site for cell surface proteoglycan interaction
C-terminal Region	Contains sex hormone-binding globulin (SHBG)-like domain
Associated Diseases	APOPTOSIS, Aging, Alzheimer, Atherosclerosis, Cancer, Ms
Interactions	APOE, TRAF6, APP, AXL, ALZHEIMER'S DISEASE, DEMENTIA
KG Connections	112 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GAS6["GAS6 Gene"]
    AXL["AXL Receptor"]
    MICROGLIA["Microglia Activation"]
    INFLAMMATION["Inflammation"]
    NFKB["NF-kappaB Pathway"]
    APP["APP Processing"]
    AMYLOID["Amyloid-beta Plaques"]
    ALZHEIMER["Alzheimer's Disease"]
    NEURODEGENERATION["Neurodegeneration"]
    COMPLEMENT["Complement System"]
    APOE["APOE"]
    TRAF6["TRAF6"]
    UBIQUITIN["Ubiquitin-Proteasome"]
    PROTEASOME["Proteasome Pathway"]
    DEMENTIA["Dementia"]

    GAS6 -->|"binds to"| AXL
    GAS6 -->|"activates"| MICROGLIA
    GAS6 -->|"inhibits"| INFLAMMATION
    GAS6 -->|"activates"| NFKB
    GAS6 -->|"promotes"| APP
    GAS6 -->|"leads to"| AMYLOID
    GAS6 -->|"contributes to"| ALZHEIMER
    GAS6 -->|"drives"| NEURODEGENERATION
    GAS6 -->|"involves"| COMPLEMENT
    GAS6 -->|"inhibits"| APOE
    GAS6 -->|"inhibits"| TRAF6
    GAS6 -->|"regulates"| UBIQUITIN
    GAS6 -->|"activates"| PROTEASOME
    
    AXL -->|"triggers"| MICROGLIA
    MICROGLIA -->|"produces"| INFLAMMATION
    APP -->|"generates"| AMYLOID
    AMYLOID -->|"causes"| ALZHEIMER
    ALZHEIMER -->|"results in"| DEMENTIA
    NEURODEGENERATION -->|"leads to"| DEMENTIA

    style GAS6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style INFLAMMATION fill:#1b5e20
    style APOE fill:#1b5e20
    style ALZHEIMER fill:#7d4200
    style NEURODEGENERATION fill:#7d4200
    style DEMENTIA fill:#7d4200
    style AXL fill:#4a1a6b
    style NFKB fill:#4a1a6b
    style TRAF6 fill:#4a1a6b
    style MICROGLIA fill:#ef5350
    style AMYLOID fill:#ef5350
    style APP fill:#ef5350

Outgoing (73)

Target	Relation	Type	Str
AXL	inhibits	gene	0.65
Atherosclerosis	implicated_in	disease	0.65
Inflammation	inhibits	disease	0.65
Als	activates	disease	0.65
Longevity	activates	disease	0.65
Alzheimer	activates	disease	0.65
Anxiety	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Dementia	activates	disease	0.65
Ms	causes	disease	0.65
Cancer	causes	disease	0.65
Aging	causes	disease	0.65
Alzheimer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
INFLAMMATION	activates	phenotype	0.65
MICROGLIA	regulates	cell_type	0.65
MICROGLIA	inhibits	cell_type	0.65
APOE	inhibits	gene	0.60
TRAF6	inhibits	gene	0.60
UBIQUITIN	associated_with	gene	0.60
APP	activates	gene	0.60
AXL	activates	gene	0.60
AXL	associated_with	gene	0.60
PPAR	regulates	gene	0.60
cardiovascular disease	regulates	disease	0.60
Differentiation	implicated_in	pathway	0.60
Complement	implicated_in	pathway	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
DEMENTIA	activates	gene	0.60
Ubiquitin-Proteasome	associated_with	pathway	0.60
Nf-Κb	activates	pathway	0.60
Proteasome	activates	pathway	0.60
APP/PS1	activates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
AMYLOID-Β PLAQUES	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
Phagocytosis	activates	pathway	0.60
ASTROCYTES	causes	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	associated_with	gene	0.60
AND	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
HER2	causes	gene	0.60
Microglia	associated_with	cell_type	0.60
Astrocyte	associated_with	cell_type	0.60
ASTROCYTES	associated_with	gene	0.60

Incoming (39)

Source	Relation	Type	Str
AXL	regulates	gene	0.65
MICROGLIA	causes	cell_type	0.65
MACROPHAGE	activates	cell_type	0.65
SPINAL CORD	activates	brain_region	0.65
SPINAL CORD	regulates	brain_region	0.65
STRIATUM	treats	brain_region	0.65
TAU	activates	gene	0.60
SIRT1	activates	gene	0.60
AXL	associated_with	gene	0.60
AXL	interacts_with	gene	0.60
ABCA1	expressed_in	gene	0.60
ABCA7	expressed_in	gene	0.60
ABCG1	expressed_in	gene	0.60
ABCA1	activates	gene	0.60
ABCA7	activates	gene	0.60
ABCG1	activates	gene	0.60
ABCA1	regulates	gene	0.60
ABCA7	regulates	gene	0.60
ABCG1	regulates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ANXIETY	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NF-ΚB	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CANCER	causes	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
HER2	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
MERTK	implicated_in	gene	0.55
microglia	interacts_with	cell_type	0.50
SPINAL CORD	associated_with	brain_region	0.45
STRIATUM	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R	0.498	neuroinflammation	Why do TAM receptors protect against neu

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GAS6

Understanding Entity Pages

Summary

Wiki Pages (16)

GAS6 - Growth Arrest Specific 6

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

TAM Receptor Signaling

Efferocytosis in Neurodegeneration

MERTK - MER Tyrosine Kinase

AXL - AXL Receptor Tyrosine Kinase

Microglia-Targeted Nanoparticles for CNS Delivery

TYRO3 - TYRO3 Receptor Tyrosine Kinase

AD Microglial Phagocytosis and Synaptic Pruning Companies

Axl Protein

TAM Receptor Modulation Therapy

Tyro3 Protein

Striatum in Procedural Memory

VKORC1L1 Gene - Vitamin K Epoxide Reductase Complex Subunit 1-Like 1