gene

USP30

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USP30: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

148Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Gene profile: USP30 — Ubiquitin Specific Peptidase 30, a mitochondria-localized deubiquitinase critical for mitophagy regulation and a promising therapeutic target in Parkinson's disease

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🧬 Gene Info

Gene Symbol	USP30
Full Name	Ubiquitin Specific Peptidase 30
Chromosome	12p11.23
Protein Type	Enzyme
Function	is a critical deubiquitinating enzyme (DUB) uniquely localized to the outer mitochondrial membrane (OMM), where it serves as a key regulator of mitochondrial quality control through mitophagy [@bin...
Subcellular Localization	the outer mitochondrial membrane (OMM), where it serves as a key regulator of mitochondrial quality control through mito
Molecular Weight	58 kDa
Amino Acids	517 aa
Pathways	Autophagy, Mitophagy
Ensembl ID	ENSG00000196811
GeneCards	USP30
Human Protein Atlas	USP30
N-terminus	Cytoplasmic (facing the cytosol)
C-terminus	Intermembrane space-facing
Substrate specificity	Prefers K6- and K63-linked ubiquitin chains
Associated Diseases	Als, Cardiac, Ms
Interactions	FOXO3, HSPD1, COX4I1, GRIA2, PRKN, OPTN
KG Connections	148 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    USP30["USP30"] -->|"activates"| Aging["Aging"]
    USP30["USP30"] -->|"activates"| Cardiovascular["Cardiovascular"]
    USP30["USP30"] -->|"therapeutic target"| Parkinson["Parkinson"]
    USP30["USP30"] -->|"therapeutic target"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    USP30["USP30"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    USP30["USP30"] -->|"activates"| Als["Als"]
    USP30["USP30"] -->|"therapeutic target"| Huntington["Huntington"]
    USP30["USP30"] -->|"therapeutic target"| Ms["Ms"]
    USP30["USP30"] -->|"regulates"| Parkinson["Parkinson"]
    USP30["USP30"] -->|"regulates"| Alzheimer["Alzheimer"]
    USP30["USP30"] -->|"therapeutic target"| Als["Als"]
    USP30["USP30"] -->|"associated with"| Ms["Ms"]
    style USP30 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Huntington fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (88)

Target	Relation	Type	Str
dopaminergic neurons	protects_against	cell_type	1.00
phospho-S129 αSyn	decreases	protein	0.90
Parkinson	regulates	disease	0.75
Parkinson	inhibits	disease	0.75
Mitophagy	activates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Aging	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Huntington	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Als	inhibits	disease	0.65
Synucleinopathy	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Als	regulates	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Als	implicated_in	disease	0.65
Cardiac	implicated_in	disease	0.65
Parkinson	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
ALS	activates	disease	0.65
Alzheimer	activates	disease	0.65
Huntington	activates	disease	0.65
FOXO3	activates	gene	0.60
HSPD1	activates	gene	0.60
COX4I1	activates	gene	0.60
GRIA2	activates	gene	0.60
PRKN	activates	gene	0.60
OPTN	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MYO7A	activates	gene	0.60
ATF3	activates	gene	0.60
PINK1	activates	gene	0.60
TOMM20	activates	gene	0.60
PARKIN	activates	gene	0.60
XBP1	activates	gene	0.60
PINK1	associated_with	gene	0.60
MUL1	regulates	gene	0.60
UBIQUITIN	activates	gene	0.60
PARKIN	inhibits	gene	0.60
UBIQUITIN	regulates	gene	0.60
PARKIN	regulates	gene	0.60
PARKIN	implicated_in	gene	0.60
HSP60	activates	gene	0.60

Incoming (60)

Source	Relation	Type	Str
PARKIN	activates	gene	0.70
PINK1	activates	gene	0.70
MITOPHAGY	activates	gene	0.70
PARKINSON'S DISEASE	regulates	gene	0.70
PARKINSON'S DISEASE	inhibits	gene	0.70
PARKINSON	inhibits	gene	0.70
MYO7A	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
OPTN	activates	gene	0.60
XBP1	activates	gene	0.60
ATF3	activates	gene	0.60
TOMM20	activates	gene	0.60
PTEN	activates	gene	0.60
PARKIN	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
UBIQUITIN	activates	gene	0.60
PRKN	activates	gene	0.60
HSPD1	activates	gene	0.60
FOXO3	activates	gene	0.60
HSP60	activates	gene	0.60
OPTINEURIN	activates	gene	0.60
GRIA2	activates	gene	0.60
COX4I1	activates	gene	0.60
PINK1	causes	gene	0.60
PARK2	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
SNCA	inhibits	gene	0.60
PINK1	regulates	gene	0.60
PINK1	implicated_in	gene	0.60
PARL	implicated_in	gene	0.60
CPT2	implicated_in	gene	0.60
FUS	activates	gene	0.60
CDK5	regulates	gene	0.60
MAVS	regulates	gene	0.60
FBXO7	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
ALZHEIMER DISEASE	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
LC3B	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOPHAGY	inhibits	gene	0.60
GENES	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
AUTOPHAGY	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

USP30

Understanding Entity Pages

Summary

Wiki Pages (21)

USP30 — Ubiquitin Specific Peptidase 30

Mitophagy Pathway in Neurodegeneration

ubiquitin-proteasome-dysfunction-neurodegeneration

pink1-parkin-mitophagy-pd-causal-chain

mitochondrial-dynamics

Mechanisms Dashboard

Ubiquitin-Proteasome System Dysfunction in Neurodegeneration

autophagy-lysosome-dysfunction

Ubiquitin-Proteasome System Dysfunction in Parkinson's Disease

Protein Quality Control in Neurodegeneration

Mitophagy

Mitochondrial Dysfunction in PD

Dopaminergic Neurons

Parkin Activators for Parkinson's Disease

Autophagy Enhancers for PD

Autophagy and Mitophagy Therapeutics Investment Landscape

USP13 Inhibitor for Mitophagy and Synaptic Proteostasis

Section 194: Advanced Mitochondrial Dynamics and Biogenesis Therapy in CBS/PSP

Ubiquitin Signatures on Aggregating Proteins