Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TUBG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gene profile: TUBG1 — Tubulin Gamma 1, a core component of the microtubule organizing center essential for microtubule nucleation, neuronal morphogenesis, and axonal transport in neurodegenerative diseases
| Gene Symbol | TUBG1 |
| Full Name | Tubulin Gamma 1 |
| Chromosome | 17q21.2 |
| Molecular Weight | 51 kDa |
| Amino Acids | 451 aa |
| Ensembl ID | ENSG00000131462 |
| GeneCards | TUBG1 |
| Human Protein Atlas | TUBG1 |
| Core structure | 13 gamma-tubulins arranged in a helical ring |
| Associated proteins | GCP2 (NEDD1), GCP3, GCP4, GCP5, GCP6 |
| Dimensions | ~25 nm diameter, ~8 nm thick |
| Template function | Provides 13-fold symmetry matching microtubule lattice |
| T7 loop | Mediates lateral interactions between gamma-tubulins |
| MIP domain | Interfaces with alpha/beta-tubulin dimers |
| Centrosomin-binding domain | Required for MTOC localization |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACTB, ATG5, BECN1, CAT, CDKN1A, CTSD |
| KG Connections | 34 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TUBG1["<b>TUBG1</b>"]
Cancer{"Cancer"}
TUBG1 -->|"therapeutic target"| Cancer
Tumor{"Tumor"}
TUBG1 -->|"therapeutic target"| Tumor
neurodegeneration["neurodegeneration"]
TUBG1 -->|"implicated in"| neurodegeneration
E2F1["E2F1"]
E2F1 -->|"associated with"| TUBG1
CANCER["CANCER"]
CANCER -->|"therapeutic target"| TUBG1
RB1["RB1"]
RB1 -->|"therapeutic target"| TUBG1
style TUBG1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| senescence | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| E2F1 | associated_with | gene | 0.60 |
| RB1 | therapeutic_target | gene | 0.60 |
| ACTB | activates | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| CAT | activates | gene | 0.60 |
| CDKN1A | activates | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| CYCS | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| GLB1 | activates | gene | 0.60 |
| LAMP2 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| NBR1 | activates | gene | 0.60 |
| NFE2L2 | activates | gene | 0.60 |
| NOX1 | activates | gene | 0.60 |
| OPTN | activates | gene | 0.60 |
| PPARGC1A | activates | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| TFRC | activates | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| NADPH | activates | gene | 0.60 |
| NFKB | activates | gene | 0.60 |
| P21 | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| ROS | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||