protein

NADPH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NADPH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

200Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for NADPH Oxidase 2

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🔬 Protein Info

Gene Symbol	NADPH
Molecular Weight	65.3 kDa
Pathways	p38/MAPK, oxidative stress response, insulin signaling, inflammation, Toll-Like Receptor
GeneCards	NADPH
Human Protein Atlas	NADPH
Associated Diseases	ALS, neurodegeneration, stroke
Known Drugs/Compounds	Glaucoma, metformin, p38, rapamycin
Interactions	ACTB, AMBRA1, AMPK, ATG5, ATP, BAK1
KG Connections	196 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NADPH["NADPH"]
    Lipid_Peroxidation["Lipid Peroxidation"]
    NADPH -->|"inhibits"| Lipid_Peroxidation
    Ferroptosis["Ferroptosis"]
    NADPH -->|"protects against"| Ferroptosis
    IDH1["IDH1"]
    IDH1 -->|"catalyzes"| NADPH
    IDH2["IDH2"]
    IDH2 -->|"upregulates"| NADPH
    IDH1["IDH1"]
    IDH1 -->|"associated with"| NADPH
    IDH2["IDH2"]
    IDH2 -->|"associated with"| NADPH
    Glucose_6_Phosphate_Dehydrogenase_Deficiency["Glucose-6-Phosphate Dehydrogenase Deficiency"]
    Glucose_6_Phosphate_Dehydrogenase_Deficiency -->|"associated with"| NADPH
    p38["p38"]
    NADPH -->|"inhibits"| p38
    Glaucoma["Glaucoma"]
    NADPH -->|"treats"| Glaucoma
    NRF2["NRF2"]
    NRF2 -->|"regulates"| NADPH
    NADH["NADH"]
    NADPH -->|"activates"| NADH
    GENE_EXPRESSION["GENE EXPRESSION"]
    NADPH -->|"activates"| GENE_EXPRESSION
    NEURONS["NEURONS"]
    NADPH -->|"inhibits"| NEURONS
    ENDOPLASMIC_RETICULUM["ENDOPLASMIC RETICULUM"]
    NADPH -->|"regulates"| ENDOPLASMIC_RETICULUM
    CATALASE["CATALASE"]
    NADPH -->|"associated with"| CATALASE
    PUMA["PUMA"]
    NADPH -->|"activates"| PUMA
    FIS1["FIS1"]
    NADPH -->|"activates"| FIS1
    BECLIN1["BECLIN1"]
    NADPH -->|"activates"| BECLIN1
    HO_1["HO-1"]
    NADPH -->|"activates"| HO_1
    inflammation["inflammation"]
    NADPH -->|"activates"| inflammation
    apoptosis["apoptosis"]
    NADPH -->|"activates"| apoptosis
    oxidative_stress["oxidative stress"]
    NADPH -->|"activates"| oxidative_stress
    BCL_2["BCL-2"]
    NADPH -->|"activates"| BCL_2
    Toll_Like_Receptor["Toll-Like Receptor"]
    NADPH -->|"activates"| Toll_Like_Receptor
    Lymphoma["Lymphoma"]
    NADPH -->|"activates"| Lymphoma
    ENDOTHELIAL["ENDOTHELIAL"]
    NADPH -->|"activates"| ENDOTHELIAL
    RAPAMYCIN["RAPAMYCIN"]
    NADPH -->|"activates"| RAPAMYCIN
    MAPK["MAPK"]
    NADPH -->|"activates"| MAPK
    Hypertension["Hypertension"]
    NADPH -->|"activates"| Hypertension
    GLIOSIS["GLIOSIS"]
    NADPH -->|"activates"| GLIOSIS

Outgoing (119)

Target	Relation	Type	Str
ROS	activates	gene	0.90
Neurodegeneration	protects_against	process	0.85
Peroxidation	inhibits	process	0.82
p38/MAPK	inhibits	pathway	0.80
ferroptosis	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.75
Glaucoma	treats	disease	0.75
p38	inhibits	protein	0.70
Glaucoma	treats	disease	0.70
ROS	associated_with	gene	0.70
microglia	expressed_in	cell_type	0.70
SIRT1	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
TUBG1	activates	gene	0.60
NOX1	activates	gene	0.60
NBR1	activates	gene	0.60
OPTN	activates	gene	0.60
senescence	participates_in	pathway	0.60
TRAF6	activates	gene	0.60
NRF2	regulates	gene	0.60
TAAR1	activates	gene	0.60
NOX4	inhibits	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
NFE2L2	activates	gene	0.60
NFKB	activates	gene	0.60
P21	activates	gene	0.60
PPARGC1A	activates	gene	0.60
TFEB	activates	gene	0.60
TFRC	activates	gene	0.60
Wnt signaling	participates_in	pathway	0.60
TLR	activates	gene	0.60
MAPK signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
PARL	activates	gene	0.60
PINK1	activates	gene	0.60
P53	activates	gene	0.60
PRKN	activates	gene	0.60
NLRP3	activates	gene	0.60
SLC7A11	activates	gene	0.60
NOX	activates	gene	0.60
PTEN	activates	gene	0.60
SQSTM1	activates	gene	0.60
VCP	activates	gene	0.60
TXN	activates	gene	0.60
VEGF	activates	gene	0.60
NIX	activates	gene	0.60
ALS	associated_with	disease	0.60
stroke	associated_with	disease	0.60
NLR	activates	gene	0.60

Incoming (81)

Source	Relation	Type	Str
IDH1	associated_with	gene	0.90
IDH2	upregulates	entity	0.90
IDH2	associated_with	entity	0.90
NRF2	regulates	protein	0.64
GSH	inhibits	gene	0.60
CYCS	activates	gene	0.60
GAPDH	activates	gene	0.60
GLB1	activates	gene	0.60
LAMP2	activates	gene	0.60
MTOR	activates	gene	0.60
rapamycin	targets	drug	0.60
IDH2	regulates	gene	0.60
NADH	activates	gene	0.60
CNO	protects_against	gene	0.60
GSK3B	activates	gene	0.60
GSR	activates	gene	0.60
HIF1A	activates	gene	0.60
HUWE1	activates	gene	0.60
IL1B	activates	gene	0.60
LC3	activates	gene	0.60
MUL1	activates	gene	0.60
ACTB	activates	gene	0.60
ATG5	activates	gene	0.60
CDKN1A	activates	gene	0.60
CTSD	activates	gene	0.60
AMPK	activates	gene	0.60
ATP	activates	gene	0.60
NAD	regulates	gene	0.60
NADH	regulates	gene	0.60
BNIP3L	activates	gene	0.60
CASP1	activates	gene	0.60
CAT	activates	gene	0.60
CNP	activates	gene	0.60
DNM1L	activates	gene	0.60
DRP1	activates	gene	0.60
FUNDC1	activates	gene	0.60
G6PD	activates	gene	0.60
GSH	activates	gene	0.60
metformin	targets	drug	0.60
JNK	activates	gene	0.60
MAPK	activates	gene	0.60
LRRK2	inhibits	gene	0.60
AMBRA1	activates	gene	0.60
BAK1	activates	gene	0.60
BAX	activates	gene	0.60
BECN1	activates	gene	0.60
BNIP3	activates	gene	0.60
HK2	inhibits	gene	0.55
GSH	associated_with	gene	0.55
IDH2	interacts_with	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte-specific autophagy deficiency induces NADPH oxidas	0.390	als	How do non-cell autonomous effects of au

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NADPH in their description or question text

No additional research found