Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about aqp4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | AQP4 |
| Chromosome | 18q11.2 |
| Protein Family | Aquaporin (AQP) family |
| Target Class | Ion Channel |
| Mechanism of Action | Water channel inhibitor or modulator |
| Primary Expression | Astrocytes (perivascular endfeet), Ependyma, Kidney collecting duct |
| Subcellular Localization | Astrocyte end-feet, perivascular, ependymal |
| Druggability | Low (0.35) |
| Clinical Stage | Phase I |
| Molecular Weight | 34 kDa |
| Amino Acids | 323 aa |
| Pathways | Adaptive Immunity, Apoptosis, Blood-Brain Barrier, Chaperone, Glymphatic Pathway |
| UniProt ID | P55064 |
| Ensembl ID | ENSG00000171885 |
| GeneCards | AQP4 |
| Human Protein Atlas | AQP4 |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | TGN-020 |
| SciDEX Target | View Target Profile (1 clinical trials) |
| SciDEX Hypotheses | SASP-Driven Aquaporin-4 Dysregulation Glymphatic System-Enhanced Antibody Clearance Reve Aquaporin-4 Polarization Rescue |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
AQP4(["AQP4"])
NMOSD["NMOSD"]
Glymphatic_System("Glymphatic System")
Central_Nervous_System["/"Central Nervous System"/"]
Neuromyelitis_Optica_Spectrum_Disorder["Neuromyelitis Optica Spectrum Di..."]
Glymphatic_Pathway["Glymphatic Pathway"]
Water_Flux("Water Flux")
Sepsis_Associated_Encephalopathy["Sepsis-Associated Encephalopathy"]
GLYMPHATIC_SYSTEM["GLYMPHATIC SYSTEM"]
COMPLEMENT_CASCADE["COMPLEMENT CASCADE"]
NEUROMYELITIS_OPTICA_SPECTRUM_DISORDER["NEUROMYELITIS OPTICA SPECTRUM DI..."]
AQP4_Ab(["AQP4-Ab"])
Neuromyelitis_Optica["Neuromyelitis Optica"]
Central_Nervous_System_Disorders["Central Nervous System Disorders"]
AQP4 -->|"biomarker for"| NMOSD
AQP4 -->|"involved in"| Glymphatic_System
AQP4 -->|"expressed in"| Central_Nervous_System
AQP4 -->|"biomarker for"| Neuromyelitis_Optica_Spectrum_Disorder
AQP4 -->|"involved in"| Glymphatic_Pathway
AQP4 -->|"mediates"| Water_Flux
AQP4 -->|"associated with"| Sepsis_Associated_Encephalopathy
AQP4 -->|"associated with"| Glymphatic_System
AQP4 -->|"involved in"| GLYMPHATIC_SYSTEM
AQP4 -->|"activates"| COMPLEMENT_CASCADE
AQP4 -->|"associated with"| NEUROMYELITIS_OPTICA_SPECTRUM_DISORDER
AQP4 -->|"biomarker for"| NEUROMYELITIS_OPTICA_SPECTRUM_DISORDER
AQP4_Ab -->|"binds"| AQP4
AQP4 -->|"associated with"| Neuromyelitis_Optica
AQP4 -->|"associated with"| Central_Nervous_System_Disorders
style AQP4 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | implicated_in | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-f2c28aed24a7 | data_in | dataset | 1.00 |
| AQP4-Ab | binds | protein | 0.95 |
| AQP4-ANTIBODY | binds | protein | 0.95 |
| IGG AUTOANTIBODY | binds | protein | 0.95 |
| TGN-020 | targets | drug | 0.95 |
| TGN-020 | inhibits | drug | 0.90 |
| Cecal Ligation and Perforation | upregulates | process | 0.90 |
| B cells | regulates | cell_type | 0.90 |
| B Cells | regulates | cell_type | 0.90 |
| h-c8ccbee8 | targets_gene | hypothesis | 0.90 |
| h-62e56eb9 | targets_gene | hypothesis | 0.90 |
| h-807d7a82 | targets_gene | hypothesis | 0.90 |
| B Cells | interacts_with | cell_type | 0.85 |
| B Cells | modulates | cell_type | 0.85 |
| Estrogen | upregulates | compound | 0.85 |
| Progesterone | upregulates | compound | 0.85 |
| Testosterone | upregulates | compound | 0.85 |
| SDA-2026-04-01-gap-013 | targets | analysis | 0.85 |
| Plasmablast/Plasma Cell | associated_with | cell_type | 0.85 |
| h-c8ccbee8 | targets | hypothesis | 0.80 |
| h-62e56eb9 | targets | hypothesis | 0.80 |
| h-807d7a82 | targets | hypothesis | 0.80 |
| MMP9 | inhibits | gene | 0.80 |
| B Cells | associated_with | cell_type | 0.80 |
| GFAP | co-regulated_with | protein | 0.80 |
| P38MAPK | regulates | pathway | 0.80 |
| TDP-43 | downregulates | protein | 0.80 |
| AQP1 | co_mentioned_with | gene | 0.80 |
| BHB | regulates | compound | 0.80 |
| Musk | downregulates | drug | 0.80 |
| TMAO | downregulates | drug | 0.80 |
| MTNR1A | regulates_expression | gene | 0.80 |
| TNF | downregulates | gene | 0.80 |
| IL1B | downregulates | gene | 0.80 |
| Microglia | involved_in | cell_type | 0.75 |
| Reactive Astrogliosis | modulates | process | 0.75 |
| RILUZOLE | causes | drug | 0.70 |
| GABA | causes | phenotype | 0.70 |
| SENESCENCE | stabilizes | phenotype | 0.70 |
| MELATONIN | activates | drug | 0.70 |
| MELATONIN | regulates | drug | 0.70 |
| ALZHEIMER'S DISEASE | causes | disease | 0.70 |
| CSF | activates | phenotype | 0.65 |
| TH | interacts_with | gene | 0.65 |
| ABCA1 | co_discussed | gene | 0.65 |
| GLYMPHATIC CLEARANCE | interacts_with | phenotype | 0.65 |
| ALPHA-SYNUCLEIN | associated_with | concept | 0.65 |
| ASTROCYTE | targets | cell_type | 0.65 |
| ASTROCYTE | treats | cell_type | 0.65 |
| GLIOSIS | inhibits | phenotype | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ | 0.612 | neuroinflammation | How do B cells mechanistically orchestra |
| IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral | 0.601 | neuroinflammation | How do B cells mechanistically orchestra |
| TREM2-Dependent Microglial Surveillance Controls AQP4-Mediat | 0.452 | neuroscience | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.612
neurodegeneration | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||