gene

aqp4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about aqp4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1825Connections
3Hypotheses
3Analyses
1Outgoing
50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolAQP4
Chromosome18q11.2
Protein FamilyAquaporin (AQP) family
Target ClassIon Channel
Mechanism of ActionWater channel inhibitor or modulator
Primary ExpressionAstrocytes (perivascular endfeet), Ependyma, Kidney collecting duct
Subcellular LocalizationAstrocyte end-feet, perivascular, ependymal
DruggabilityLow (0.35)
Clinical StagePhase I
Molecular Weight34 kDa
Amino Acids323 aa
PathwaysAdaptive Immunity, Apoptosis, Blood-Brain Barrier, Chaperone, Glymphatic Pathway
UniProt IDP55064
Ensembl IDENSG00000171885
GeneCardsAQP4
Human Protein AtlasAQP4
Associated Diseasesneurodegeneration
Known Drugs/CompoundsTGN-020
SciDEX TargetView Target Profile (1 clinical trials)
SciDEX HypothesesSASP-Driven Aquaporin-4 Dysregulation
Glymphatic System-Enhanced Antibody Clearance Reve
Aquaporin-4 Polarization Rescue
KG Connections1 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🧬 3D Structure: aqp4 — PDB 7O3C Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pituicytes - Expanded

cell · 630 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

Sleep and Circadian Dysfunction in Alzheimer's Disease

mechanism · 8066 words

CBS/PSP Supplements Guide

therapeutic · 6929 words

calcium-dysregulation-comparison

mechanism · 6468 words

neuroinflammation

mechanism · 5462 words

Pathway Diagram

flowchart TD
    AQP4(["AQP4"])
    NMOSD["NMOSD"]
    Glymphatic_System("Glymphatic System")
    Central_Nervous_System["/"Central Nervous System"/"]
    Neuromyelitis_Optica_Spectrum_Disorder["Neuromyelitis Optica Spectrum Di..."]
    Glymphatic_Pathway["Glymphatic Pathway"]
    Water_Flux("Water Flux")
    Sepsis_Associated_Encephalopathy["Sepsis-Associated Encephalopathy"]
    GLYMPHATIC_SYSTEM["GLYMPHATIC SYSTEM"]
    COMPLEMENT_CASCADE["COMPLEMENT CASCADE"]
    NEUROMYELITIS_OPTICA_SPECTRUM_DISORDER["NEUROMYELITIS OPTICA SPECTRUM DI..."]
    AQP4_Ab(["AQP4-Ab"])
    Neuromyelitis_Optica["Neuromyelitis Optica"]
    Central_Nervous_System_Disorders["Central Nervous System Disorders"]

    AQP4 -->|"biomarker for"| NMOSD
    AQP4 -->|"involved in"| Glymphatic_System
    AQP4 -->|"expressed in"| Central_Nervous_System
    AQP4 -->|"biomarker for"| Neuromyelitis_Optica_Spectrum_Disorder
    AQP4 -->|"involved in"| Glymphatic_Pathway
    AQP4 -->|"mediates"| Water_Flux
    AQP4 -->|"associated with"| Sepsis_Associated_Encephalopathy
    AQP4 -->|"associated with"| Glymphatic_System
    AQP4 -->|"involved in"| GLYMPHATIC_SYSTEM
    AQP4 -->|"activates"| COMPLEMENT_CASCADE
    AQP4 -->|"associated with"| NEUROMYELITIS_OPTICA_SPECTRUM_DISORDER
    AQP4 -->|"biomarker for"| NEUROMYELITIS_OPTICA_SPECTRUM_DISORDER
    AQP4_Ab -->|"binds"| AQP4
    AQP4 -->|"associated with"| Neuromyelitis_Optica
    AQP4 -->|"associated with"| Central_Nervous_System_Disorders

    style AQP4 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1381)

TargetRelationTypeStr
neurodegenerationimplicated_indisease0.50

Incoming (444)

SourceRelationTypeStr
ds-f2c28aed24a7data_indataset1.00
AQP4-Abbindsprotein0.95
AQP4-ANTIBODYbindsprotein0.95
IGG AUTOANTIBODYbindsprotein0.95
TGN-020targetsdrug0.95

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ 0.612 neuroinflammation How do B cells mechanistically orchestra
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral 0.601 neuroinflammation How do B cells mechanistically orchestra
TREM2-Dependent Microglial Surveillance Controls AQP4-Mediat 0.452 neuroscience Circuit-level neural dynamics in neurode

Mentioning Analyses (3)

Scientific analyses that reference this entity

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.612

What are the specific molecular mechanisms by which AQP4 dysfunction contributes

neurodegeneration | 2026-04-07 | 0 hypotheses

How can AQP4 be effectively targeted therapeutically to improve neurological out

neurodegeneration | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found