gene

MSH3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MSH3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

87Connections
0Hypotheses
1Analyses
50Outgoing
31Incoming

Summary

MSH3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with Als, Cancer, Colorectal Cancer. Connected to 32 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolMSH3
Full NameMutS Homolog 3
Chromosome5q31.1
FunctionMSH3 (MutS Homolog 3) encodes a key DNA mismatch repair (MMR) protein that forms the MutSβ heterodimer with MSH2.
PathwaysApoptosis, Dna Repair, Epigenetic
UniProt ID[P54205](https://www.uniprot.org/uniprot/P54205)
Ensembl IDENSG00000110899
GeneCardsMSH3
Human Protein AtlasMSH3
Associated DiseasesAls, Alzheimer, Alzheimer'S Disease, Cancer, Colorectal Cancer
InteractionsMSH6, PMS2, LIG1, MLH1, MSH2, FAN1
KG Connections87 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🧬 3D Structure: MSH3 — PDB 3THW Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

MSH3 (Redirect)

redirect · 640 words

Huntington's Disease

disease · 4606 words

rankings

general · 4519 words

dna-damage-repair

mechanism · 3555 words

Huntingtin Protein (HTT)

protein · 3473 words

Trinucleotide Repeat Expansion Disorders

mechanism · 3379 words

Pathway Diagram

graph TD
    MSH3["<b>MSH3</b>"]
    Huntington{"Huntington"}
    MSH3 -->|"associated with"| Huntington
    Als{"Als"}
    MSH3 -->|"associated with"| Als
    Ms{"Ms"}
    MSH3 -->|"associated with"| Ms
    FAN1["FAN1"]
    MSH3 -->|"associated with"| FAN1
    DNA["DNA"]
    MSH3 -->|"associated with"| DNA
    HTT["HTT"]
    MSH3 -->|"associated with"| HTT
    PMS2["PMS2"]
    MSH3 -->|"associated with"| PMS2
    GENETIC_MODIFIERS["GENETIC MODIFIERS"]
    MSH3 -->|"associated with"| GENETIC_MODIFIERS
    HUNTINGTON["HUNTINGTON"]
    MSH3 -->|"associated with"| HUNTINGTON
    AND["AND"]
    MSH3 -->|"associated with"| AND
    neurodegeneration["neurodegeneration"]
    MSH3 -->|"implicated in"| neurodegeneration
    style MSH3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (56)

TargetRelationTypeStr
CAG repeat expansioncauses (MSH3 drives somatic expansion of HTT CAG repeats t)mechanism0.85
Alsassociated_withdisease0.75
PMS2associated_withgene0.70
Cag Repeatstabilizesmechanism0.70
Huntingtonassociated_withdisease0.65

Incoming (31)

SourceRelationTypeStr
h-3e7d4f97targets_genehypothesis0.90
CRISPRinhibitsmechanism0.80
h-3e7d4f97targetshypothesis0.65
BAXregulatesgene0.60
BRAFassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found