Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Prostate Cancer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | HSPG2, CANCER, MIRNAS, DNA, GENES, CXCL12, CXCR4, AUTOPHAGY |
| Therapeutic Agents | Quercetin, Prostate Cancer Immunotherapy, Androgen Ablation, Klk2-Targeting Therapeutics, Docetaxel |
| KG Connections | 462 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Prostate_Cancer["<b>Prostate Cancer</b>"]
Cancer{"Cancer"}
Prostate_Cancer -->|"expressed_in"| Cancer
Als{"Als"}
Prostate_Cancer -->|"activates"| Als
CANCER(["CANCER"])
CANCER -->|"expressed_in"| Prostate_Cancer
Tumor{"Tumor"}
Tumor -->|"associated_with"| Prostate_Cancer
style Prostate_Cancer fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | expressed_in | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Cancer | inhibits | disease | 0.95 |
| Black Population | associated_with | phenotype | 0.90 |
| Bone Metastasis | causes | disease | 0.90 |
| Metastasis | activates | pathway | 0.90 |
| Apoptosis | activates | pathway | 0.90 |
| Cancer | causes | disease | 0.85 |
| Metastasis | therapeutic_target | pathway | 0.80 |
| Oxidative Stress | activates | pathway | 0.80 |
| Autophagy | therapeutic_target | pathway | 0.80 |
| Apoptosis | therapeutic_target | pathway | 0.80 |
| Invasion | activates | pathway | 0.80 |
| Tumor Microenvironment | therapeutic_target | pathway | 0.80 |
| Tumor Microenvironment | activates | pathway | 0.80 |
| Als | expressed_in | disease | 0.75 |
| Cancer | regulates | disease | 0.75 |
| Metastasis | implicated_in | pathway | 0.70 |
| Metastasis | associated_with | pathway | 0.70 |
| Glycolysis | activates | pathway | 0.70 |
| Pi3K/Akt | inhibits | pathway | 0.70 |
| Autophagy | activates | pathway | 0.70 |
| Notch | therapeutic_target | pathway | 0.70 |
| Wnt | therapeutic_target | pathway | 0.70 |
| Epigenetic | therapeutic_target | pathway | 0.70 |
| Drug Resistance | therapeutic_target | pathway | 0.70 |
| Angiogenesis | therapeutic_target | pathway | 0.70 |
| Immunotherapy | therapeutic_target | pathway | 0.70 |
| Senescence | activates | pathway | 0.70 |
| Tumor Microenvironment | associated_with | pathway | 0.70 |
| Drug Resistance | activates | pathway | 0.70 |
| Cell Cycle | activates | pathway | 0.70 |
| Immune Checkpoint | activates | pathway | 0.70 |
| Cancer | implicated_in | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Cancer | contributes_to | disease | 0.65 |
| Als | treats | disease | 0.65 |
| Hedgehog | therapeutic_target | pathway | 0.60 |
| Sonic Hedgehog | therapeutic_target | pathway | 0.60 |
| Dna Methylation | associated_with | pathway | 0.60 |
| Dna Repair | associated_with | pathway | 0.60 |
| Oxidative Phosphorylation | activates | pathway | 0.60 |
| Lipid Metabolism | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | expressed_in | gene | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Stress Granules | involved_in | process | 0.95 |
| Bone Metastasis | associated_with | phenotype | 0.95 |
| PI3K-AKT-mTOR | involved_in | pathway | 0.95 |
| AKT | inhibits | gene | 0.95 |
| Tumor | inhibits | disease | 0.95 |
| GENES | therapeutic_target | gene | 0.95 |
| CANCER | causes | gene | 0.95 |
| APOPTOSIS | activates | gene | 0.95 |
| Radical Prostatectomy | treats | process | 0.95 |
| KLK2 | biomarker_for | protein | 0.95 |
| Biomarkers | biomarker_for | biomarker | 0.95 |
| Androgen Ablation | treats | drug | 0.95 |
| KLK2 | targets | protein | 0.95 |
| Biomarker | biomarker_for | biomarker | 0.95 |
| MTOR | activates | protein | 0.95 |
| HOXB13 | risk_factor_for | gene | 0.90 |
| rs117576373 | associated_with | biomarker | 0.90 |
| HOXB13 G84E | risk_factor_for | biomarker | 0.90 |
| Bisphenol F | contributes_to | compound | 0.90 |
| Stress Granules | promotes | process | 0.90 |
| Radiotherapy | treats | process | 0.90 |
| SPOP | suppresses | protein | 0.90 |
| Docetaxel | treats | drug | 0.90 |
| Spop Mutations | contributes_to | variant | 0.90 |
| Perlecan | regulates | protein | 0.90 |
| Perlecan | associated_with | protein | 0.88 |
| SPOP mutations | risk_factor_for | phenotype | 0.88 |
| G3BP1 | upregulates | protein | 0.85 |
| HSPG2 | associated_with | gene | 0.85 |
| TUBB3 | biomarker_for | gene | 0.85 |
| CAR T Cell Therapy | treats | cell_type | 0.85 |
| PI3K | inhibits | gene | 0.85 |
| Tumor | expressed_in | disease | 0.85 |
| OXIDATIVE STRESS | activates | gene | 0.85 |
| AUTOPHAGY | therapeutic_target | gene | 0.85 |
| APOPTOSIS | therapeutic_target | gene | 0.85 |
| MYC | therapeutic_target | gene | 0.85 |
| CANCER | regulates | gene | 0.85 |
| PTEN | therapeutic_target | gene | 0.85 |
| Anoikis | biomarker_for | process | 0.85 |
| Prostate Cancer Immunotherapy | treats | drug | 0.85 |
| Klk2-Targeting Therapeutics | treats | drug | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||