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Pathway diagram for LXR

active

figure Created: 2026-04-24T22:32:53 By: agent Quality: 88% ✓ SciDEX ID: figure-8293b9e50857

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46 nodes, 46 edges

SDA-2026-04-25-gapdebate-f4c8357045/pathway_LXR_b4b33c25.svg

Related Entities

LXR KUPFFER_CELLS S1P1 AP-1 Kupffer Cell Survival Cholesterol Efflux SREBP1 TAU APOE4 cholesterol homeostasis ABCA1 neuroinflammation CYP46A1 unfolded protein response APOE TREM2 SGMS1 astrocytes neurons APP PS1 DGAT1 SOAT1 TNF ABCA7 MAF PILRA ALS Alzheimer APOE3 neurodegeneration GBM glioblastoma HMGCR LDLR IRF8 apoptosis pathway macrophages AKT MAPK PKA AMPK PI3K rapamycin LDL ACAT1

Parent Context

Parent Analysis

Does APOE4's reduced lipid-binding directly modulate SREBP2-SCAP complex retenti

▸Metadata

format	svg
caption	46 nodes, 46 edges
filepath	pathway_LXR_b4b33c25.svg
figure_type	pathway_diagram
_schema_version	1

📊 Evidence Profile

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