| Gene Symbol | DNA |
| Function | is an epigenetic modification that regulates gene expression without changing the DNA sequence. |
| Pathways | AMPK signaling, Adaptive Immunity, Akt, Amyloid, Angiogenesis |
| GeneCards | DNA |
| Human Protein Atlas | DNA |
| Biological aging | Epigenetic clocks measure accelerated aging |
| Disease state | Specific methylation patterns associate with AD/PD |
| Gene regulation | Dysregulated methylation affects disease pathways |
| Risk prediction | Early methylation changes may predict disease |
| Amyloid-related genes | Methylation of APP, BACE1 promoters |
| Tau pathway | Methylation changes in MAPT region |
| Inflammation | Hyper-methylation of anti-inflammatory genes |
| Epigenetic age acceleration | AD patients show 3-7 years accelerated aging |
| ANKK1 | Consistently hypermethylated in AD |
| SOD1 | Methylation of promoter in sporadic ALS |
| Associated Diseases | AD, Addiction, aging, ALI, Als |
| Known Drugs/Compounds | ketamine, metformin, rapamycin, resveratrol, valproic acid |
| Interactions | A2M, ABCB1, ABCD3, ACETYL-COA, ACTB, Actin |
| KG Connections | 5265 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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