concept

NUPR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NUPR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

69Connections

0Hypotheses

0Analyses

44Outgoing

25Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	NUPR1
Key Genes/Proteins	lactate, PDCD1LG1, PD-L1, CREB, TAAR1
Related Diseases	hepatocellular carcinoma, CD8+ T cell exhaustion, immunotherapy responsiveness, Lymphoma, Inflammation
Related Pathways	ERK, JNK, ERK signaling pathway, JNK signaling pathway

Pathway Diagram

graph TD
    NUPR1["NUPR1"]
    NUPR1 -->|"promotes"| M2_macrophage_polarization["M2 macrophage polarization"]
    NUPR1 -->|"target for"| hepatocellular_carcinoma["hepatocellular carcinoma"]
    NUPR1 -->|"inhibits"| ERK["ERK"]
    NUPR1 -->|"inhibits"| JNK["JNK"]
    NUPR1 -->|"inhibits"| ERK_signaling_pathway["ERK signaling pathway"]
    NUPR1 -->|"inhibits"| JNK_signaling_pathway["JNK signaling pathway"]
    NUPR1 -->|"promotes"| CD8__T_cell_exhaustion["CD8+ T cell exhaustion"]
    NUPR1 -->|"upregulates"| PDCD1LG1["PDCD1LG1"]
    lactate["lactate"] -->|"upregulates"| NUPR1

Outgoing (44)

Target	Relation	Type	Str
M2 macrophage polarization	promotes	process	0.95
hepatocellular carcinoma	therapeutic_target	disease	0.95
ERK	inhibits	pathway	0.95
JNK	inhibits	pathway	0.95
ERK signaling pathway	inhibits	pathway	0.90
JNK signaling pathway	inhibits	pathway	0.90
CD8+ T cell exhaustion	promotes	phenotype	0.90
PDCD1LG1	upregulates	gene	0.85
PD-L1	upregulates	protein	0.85
immunotherapy responsiveness	biomarker_for	phenotype	0.85
Lymphoma	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
CREB	associated_with	gene	0.60
TAAR1	associated_with	gene	0.60
MYD88	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
SIGMAR1	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
Blood-Brain Barrier	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Toll-Like Receptor	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
NOX	associated_with	gene	0.60
TLR	associated_with	gene	0.60
AKT	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
BCL-2	associated_with	gene	0.60
AND	associated_with	gene	0.60
BECLIN1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
PUMA	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
BAX	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
TRAF6	associated_with	gene	0.60
HO-1	associated_with	gene	0.60
RNA	activates	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
BECLIN1	regulates	protein	0.56

Incoming (25)

Source	Relation	Type	Str
lactate	upregulates	protein	0.90
NRF2	associated_with	gene	0.60
TLR	associated_with	gene	0.60
NOX	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
CHOP	associated_with	gene	0.60
P53	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
PUMA	associated_with	gene	0.60
BCL-2	associated_with	gene	0.60
BAX	associated_with	gene	0.60
AKT	associated_with	gene	0.60
TRAF6	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
HO-1	associated_with	gene	0.60
AND	associated_with	gene	0.60
BECLIN1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
MYD88	associated_with	gene	0.60
TAAR1	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
SIGMAR1	associated_with	gene	0.60
ADAR1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found