protein

WTAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WTAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections
0Hypotheses
0Analyses
50Outgoing
29Incoming

Summary

Page for WTAP Protein (Wilms' Tumor 1-Associated Protein)

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🔬 Protein Info
Gene SymbolWTAP
AliasesWilms' Tumor 1-Associated Protein
FunctionWTAP (Wilms' Tumor 1-Associated Protein) is a 399-amino acid nuclear protein that serves as a regulatory subunit of the N6-methyladenosine (m6A) methyltransferase complex.
Subcellular Localization</strong> Nucleus (nuclear speckles)</div> <div class="infobox-row"><strong>Pr
Molecular Weight44.2 kDa
Amino Acids399 aa
PathwaysWnt, Tgf-Β, Ferroptosis
GeneCardsWTAP
Human Protein AtlasWTAP
Associated DiseasesAls, Cancer
InteractionsPPARGC1A, ACSL5, BAMBI, ROS, FERROPTOSIS, WNT
KG Connections82 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (15)

Knowledge base pages for this entity

Epigenetic Mechanisms in Alzheimer's Disease

mechanism · 3425 words

RNA Stability and Decay

mechanism · 2809 words

VIRMA (KIAA1429) in Neurodegeneration

mechanism · 1785 words

Section 183: Epitranscriptomics and RNA Modifications in CBS/PSP

therapeutic · 1680 words

payload-ythdf-m6a-reader-modulation-therapy

general · 1635 words

Pathway Diagram

graph TD
    WTAP["<b>WTAP</b>"]
    Cancer{"Cancer"}
    WTAP -->|"therapeutic target"| Cancer
    Als{"Als"}
    WTAP -->|"therapeutic target"| Als
    Ms{"Ms"}
    WTAP -->|"therapeutic target"| Ms
    Carcinoma{"Carcinoma"}
    WTAP -->|"inhibits"| Carcinoma
    WTAP -->|"inhibits"| Ms
    WTAP -->|"associated with"| Als
    WTAP -->|"associated with"| Cancer
    WTAP -->|"activates"| Carcinoma
    ALS{"ALS"}
    WTAP -->|"contributes to"| ALS
    WTAP -->|"contributes to"| Cancer
    PPARGC1A["PPARGC1A"]
    WTAP -->|"inhibits"| PPARGC1A
    HNRNPA2B1["HNRNPA2B1"]
    WTAP -->|"therapeutic target"| HNRNPA2B1
    KDM5A["KDM5A"]
    KDM5A -->|"upregulates"| WTAP
    HNRNPA2B1 -->|"associated with"| WTAP
    IGF2BP1["IGF2BP1"]
    IGF2BP1 -->|"associated with"| WTAP
    METTL3["METTL3"]
    METTL3 -->|"associated with"| WTAP
    ACSL5["ACSL5"]
    ACSL5 -->|"activates"| WTAP
    BAMBI["BAMBI"]
    BAMBI -->|"activates"| WTAP
    PPARGC1A -->|"associated with"| WTAP
    GENES["GENES"]
    GENES -->|"contributes to"| WTAP
    IGF2BP1 -->|"contributes to"| WTAP
    CANCER["CANCER"]
    CANCER -->|"contributes to"| WTAP
    ROS["ROS"]
    ROS -->|"inhibits"| WTAP
    ACSL5 -->|"inhibits"| WTAP
    style WTAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

TargetRelationTypeStr
N6-Methyladenosineregulatescompound0.95
m6A Modificationregulatesprocess0.85
PPARGC1Adownregulatesgene0.85
m6A modificationmediatesprocess0.85
Cancertherapeutic_targetdisease0.65

Incoming (29)

SourceRelationTypeStr
KDM5Aupregulatesgene0.80
HNRNPA2B1associated_withgene0.60
IGF2BP1associated_withgene0.60
METTL3associated_withgene0.60
ACSL5activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found