Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WTAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | WTAP |
| Aliases | Wilms' Tumor 1-Associated Protein |
| Function | WTAP (Wilms' Tumor 1-Associated Protein) is a 399-amino acid nuclear protein that serves as a regulatory subunit of the N6-methyladenosine (m6A) methyltransferase complex. |
| Subcellular Localization | </strong> Nucleus (nuclear speckles)</div> <div class="infobox-row"><strong>Pr |
| Molecular Weight | 44.2 kDa |
| Amino Acids | 399 aa |
| Pathways | Wnt, Tgf-Β, Ferroptosis |
| GeneCards | WTAP |
| Human Protein Atlas | WTAP |
| Associated Diseases | Als, Cancer |
| Interactions | PPARGC1A, ACSL5, BAMBI, ROS, FERROPTOSIS, WNT |
| KG Connections | 82 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
WTAP["<b>WTAP</b>"]
Cancer{"Cancer"}
WTAP -->|"therapeutic target"| Cancer
Als{"Als"}
WTAP -->|"therapeutic target"| Als
Ms{"Ms"}
WTAP -->|"therapeutic target"| Ms
Carcinoma{"Carcinoma"}
WTAP -->|"inhibits"| Carcinoma
WTAP -->|"inhibits"| Ms
WTAP -->|"associated with"| Als
WTAP -->|"associated with"| Cancer
WTAP -->|"activates"| Carcinoma
ALS{"ALS"}
WTAP -->|"contributes to"| ALS
WTAP -->|"contributes to"| Cancer
PPARGC1A["PPARGC1A"]
WTAP -->|"inhibits"| PPARGC1A
HNRNPA2B1["HNRNPA2B1"]
WTAP -->|"therapeutic target"| HNRNPA2B1
KDM5A["KDM5A"]
KDM5A -->|"upregulates"| WTAP
HNRNPA2B1 -->|"associated with"| WTAP
IGF2BP1["IGF2BP1"]
IGF2BP1 -->|"associated with"| WTAP
METTL3["METTL3"]
METTL3 -->|"associated with"| WTAP
ACSL5["ACSL5"]
ACSL5 -->|"activates"| WTAP
BAMBI["BAMBI"]
BAMBI -->|"activates"| WTAP
PPARGC1A -->|"associated with"| WTAP
GENES["GENES"]
GENES -->|"contributes to"| WTAP
IGF2BP1 -->|"contributes to"| WTAP
CANCER["CANCER"]
CANCER -->|"contributes to"| WTAP
ROS["ROS"]
ROS -->|"inhibits"| WTAP
ACSL5 -->|"inhibits"| WTAP
style WTAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| N6-Methyladenosine | regulates | compound | 0.95 |
| m6A Modification | regulates | process | 0.85 |
| PPARGC1A | downregulates | gene | 0.85 |
| m6A modification | mediates | process | 0.85 |
| Cancer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| ALS | contributes_to | disease | 0.65 |
| Cancer | contributes_to | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| PPARGC1A | inhibits | gene | 0.64 |
| HNRNPA2B1 | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| IGF2BP1 | therapeutic_target | gene | 0.60 |
| METTL3 | associated_with | gene | 0.60 |
| ACSL5 | inhibits | gene | 0.60 |
| BAMBI | inhibits | gene | 0.60 |
| PPARGC1A | associated_with | gene | 0.60 |
| Wnt | inhibits | pathway | 0.60 |
| Tgf-Β | inhibits | pathway | 0.60 |
| Ferroptosis | inhibits | pathway | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| Wnt | activates | pathway | 0.60 |
| HNRNPA2B1 | contributes_to | gene | 0.60 |
| IGF2BP1 | contributes_to | gene | 0.60 |
| CANCER | contributes_to | gene | 0.60 |
| ROS | inhibits | gene | 0.60 |
| FERROPTOSIS | inhibits | gene | 0.60 |
| RNA | contributes_to | gene | 0.60 |
| ALKBH5 | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| FTO | associated_with | gene | 0.60 |
| YTHDF1 | contributes_to | gene | 0.60 |
| WNT | inhibits | gene | 0.60 |
| RNA | therapeutic_target | gene | 0.60 |
| METTL3 | inhibits | gene | 0.60 |
| Igf | therapeutic_target | protein | 0.60 |
| Ras | associated_with | protein | 0.60 |
| Rb | associated_with | protein | 0.60 |
| CSF2 | activates | gene | 0.60 |
| Stat3 | therapeutic_target | protein | 0.60 |
| RORA | expressed_in | gene | 0.60 |
| TGM2 | expressed_in | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| KDM5A | upregulates | gene | 0.80 |
| HNRNPA2B1 | associated_with | gene | 0.60 |
| IGF2BP1 | associated_with | gene | 0.60 |
| METTL3 | associated_with | gene | 0.60 |
| ACSL5 | activates | gene | 0.60 |
| BAMBI | activates | gene | 0.60 |
| PPARGC1A | associated_with | gene | 0.60 |
| GENES | contributes_to | gene | 0.60 |
| IGF2BP1 | contributes_to | gene | 0.60 |
| CANCER | contributes_to | gene | 0.60 |
| ROS | inhibits | gene | 0.60 |
| ACSL5 | inhibits | gene | 0.60 |
| BAMBI | inhibits | gene | 0.60 |
| FERROPTOSIS | inhibits | gene | 0.60 |
| HNRNPA2B1 | contributes_to | gene | 0.60 |
| WNT | inhibits | gene | 0.60 |
| FTO | associated_with | gene | 0.60 |
| RNA | therapeutic_target | gene | 0.60 |
| HNRNPA2B1 | therapeutic_target | gene | 0.60 |
| PPARGC1A | inhibits | gene | 0.60 |
| NR1D2 | expressed_in | gene | 0.60 |
| CKAP4 | expressed_in | gene | 0.60 |
| GAIN | expressed_in | gene | 0.60 |
| LAMP3 | expressed_in | gene | 0.60 |
| ABCG1 | expressed_in | gene | 0.60 |
| HDAC5 | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| METTL14 | expressed_in | gene | 0.60 |
| ALKBH5 | associated_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||