concept

CLOCK GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLOCK GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

0Hypotheses

0Analyses

50Outgoing

19Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CLOCK GENES
Key Genes/Proteins	CANCER-RELATED GENES
Related Diseases	circadian rhythm disruption, ALS, Glioblastoma, Cancer, Tumor
Related Pathways	metabolic pathways

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CLOCK_GENES["CLOCK GENES"]
    CLOCK_GENES -->|"regulates"| IMMUNE_CELLS["IMMUNE CELLS"]
    CLOCK_GENES -->|"regulates"| Tumor_Microenvironment["Tumor Microenvironment"]
    CLOCK_GENES -->|"regulates"| ALS["ALS"]
    CLOCK_GENES -->|"activates"| Glioblastoma["Glioblastoma"]
    CLOCK_GENES -->|"activates"| Cancer["Cancer"]
    CLOCK_GENES -->|"activates"| Tumor["Tumor"]
    CLOCK_GENES -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    CLOCK["CLOCK"] -->|"regulates"| CLOCK_GENES
    CLOCK_GENE["CLOCK GENE"] -->|"regulates"| CLOCK_GENES
    CCNA1["CCNA1"] -->|"regulates"| CLOCK_GENES
    CANCER["CANCER"] -->|"activates"| CLOCK_GENES
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| CLOCK_GENES
    SLEEP_WAKE_CYCLE["SLEEP-WAKE CYCLE"] -->|"regulates"| CLOCK_GENES
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| CLOCK_GENES

Outgoing (56)

Target	Relation	Type	Str
IMMUNE CELLS	regulates	entity	0.88
Tumor Microenvironment	regulates	process	0.85
CANCER-RELATED GENES	regulates	gene	0.85
metabolic pathways	regulates	pathway	0.85
ALS	regulates	disease	0.65
Glioblastoma	activates	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Tumor	activates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
CIRCADIAN CLOCK GENES	regulates	gene	0.60
BMAL1	regulates	gene	0.60
AND	regulates	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
GENES	regulates	gene	0.60
Circadian Rhythm	regulates	pathway	0.60
ARNT	regulates	gene	0.60
RNA	regulates	gene	0.60
CDK1	regulates	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Cell Cycle	regulates	pathway	0.60
Angiogenesis	regulates	pathway	0.60
AND	activates	gene	0.60
GBM	activates	gene	0.60
BMAL1	activates	gene	0.60
CRY	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
CLOCK GENE	activates	gene	0.60
GENES	activates	gene	0.60
Circadian Rhythm	activates	pathway	0.60
CIRCADIAN CLOCK GENES	contributes_to	gene	0.60
GABA	regulates	gene	0.60
GENES	contributes_to	gene	0.60
Sleep-Wake Cycle	regulates	pathway	0.60
Synaptic Plasticity	regulates	pathway	0.60
Epigenetic	regulates	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
CRY1	expressed_in	gene	0.60
APP/PS1	expressed_in	gene	0.60
CIRCADIAN CLOCK GENES	expressed_in	gene	0.60
TAU	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
AND	expressed_in	gene	0.60

Incoming (19)

Source	Relation	Type	Str
circadian rhythm disruption	downregulates	phenotype	0.85
CLOCK	regulates	gene	0.60
CLOCK GENE	regulates	gene	0.60
CCNA1	regulates	gene	0.60
CLOCK	associated_with	gene	0.60
CANCER	activates	gene	0.60
CLOCK	activates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
SLEEP-WAKE CYCLE	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
CLOCK	contributes_to	gene	0.60
CLOCK GENE	contributes_to	gene	0.60
ALZHEIMER'S DISEASE NEUROPATHOLOGY	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
APP	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CLOCK GENES

Understanding Entity Pages

Wiki Pages (20)

Clinical Management Guide for CBS/PSP

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

Circadian Rhythm in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

NPAS3 Gene

NF-kB Signaling Pathway in Neurodegeneration

Transcriptional Regulation in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Circadian Rhythm Modulation Therapy

Sleep and Neurodegeneration

Advanced Glycation End Products in Neurodegeneration

Sleep-Wake Cycle

Sleep Disruption in Alzheimer's Disease

Circadian Dysfunction Across Neurodegenerative Diseases

Sleep Architecture Changes in CBS and PSP

Circadian Rhythm Dysfunction in Alzheimer's Disease

sleep-disruption-neurodegeneration