gene

CXCR3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

204Connections

0Hypotheses

6Analyses

50Outgoing

50Incoming

0Experiments

8Debates

Summary

CXCR3 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, therapeutic target. Associated with ALS, Aging, Als. Connected to 113 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CXCR3
Full Name	C-X-C Motif Chemokine Receptor 3
Chromosome	Xq13.1
Protein Type	Receptor
Function	CXCR3 is a chemokine receptor that plays critical roles in immune cell trafficking and signaling:
Molecular Weight	40 kDa
Pathways	signaling: ### Ligand Binding, PI3K, MAPK pathway
UniProt ID	P49682
NCBI Gene ID	2912
Ensembl ID	ENSG00000186810
OMIM	300214
GeneCards	CXCR3
Human Protein Atlas	CXCR3
Associated Diseases	Alzheimer's disease, Cancer, Carcinoma, disease, Inflammation
Interactions	AKT, AND, ASTROCYTES, AUTOPHAGY, BECN1, CANCER
KG Connections	204 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CXCR3 — AlphaFold P49682 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CXCR3 Gene

gene · 562 words

→

CXCR3 Protein

protein · 2309 words

→

Pathway Diagram

graph TD
    CXCR3["CXCR3"] -->|"associated"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    CXCR3["CXCR3"] -->|"associated"| Neurodegeneration["Neurodegeneration"]
    CXCR3["CXCR3"] -->|"expressed in"| Multiple_Sclerosis["Multiple Sclerosis"]
    CXCR3["CXCR3"] -->|"associated"| Inflammation["Inflammation"]
    CXCR3["CXCR3"] -->|"associated"| Neuroinflammation["Neuroinflammation"]
    CXCR3["CXCR3"] -->|"expressed in"| Alzheimer["Alzheimer"]
    CXCL9["CXCL9"] -->|"interacts"| CXCR3["CXCR3"]
    CXCL10["CXCL10"] -->|"interacts"| CXCR3["CXCR3"]
    CXCL11["CXCL11"] -->|"interacts"| CXCR3["CXCR3"]
    CXCL10_1["CXCL10"] -->|"expressed in"| CXCR3["CXCR3"]
    style CXCR3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (133)

Target	Relation	Type	Str
cxcl10	regulates	protein	0.90
CD8+ T cell brain infiltration	mediates	process	0.90
KLRG1+ effector CD8+ T cell recruitment	causes	process	0.70
oxidative stress response	participates_in	pathway	0.70
macrophages	expressed_in	cell_type	0.70
Leukocyte trafficking	mediates	process	0.70
CNS immune surveillance	regulates	process	0.70
leukocyte trafficking	regulates	phenotype	0.70
Diabetes	contributes_to	disease	0.65
Autoimmune	contributes_to	disease	0.65
Tumor	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Als	contributes_to	disease	0.65
Psoriasis	contributes_to	disease	0.65
Tumor	activates	disease	0.65
Lymphoma	activates	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Inflammation	inhibits	disease	0.65
Autoimmune	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Ulcerative Colitis	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Inflammatory Bowel Disease	activates	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Encephalitis	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65

Incoming (71)

Source	Relation	Type	Str
CXCL10	interacts_with	protein	0.72
CXCL11	interacts_with	protein	0.72
CXCL9	interacts_with	protein	0.72
CCR2	expressed_in	gene	0.70
CXCL10	activates	gene	0.70
CD38	activates	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
CXCL9	activates	gene	0.60
LRP1	expressed_in	gene	0.60
CXCR4	activates	gene	0.60
IFN	associated_with	gene	0.60
FOS	activates	gene	0.60
CCR1	inhibits	gene	0.60
VIRAL INFECTIONS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
C-FOS	activates	gene	0.60
IL-6	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
CCL2	expressed_in	gene	0.60
CCL3	inhibits	gene	0.60
TNF	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
CCR5	inhibits	gene	0.60
HDAC3	inhibits	gene	0.60
CXCL9	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
CXCL11	expressed_in	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
IL-1	inhibits	gene	0.60
CXCL10	expressed_in	gene	0.60
BECN1	activates	gene	0.60
STAT3	activates	gene	0.60
P38	activates	gene	0.60
CD8	activates	gene	0.60
CXCL10	associated_with	entity	0.60
CXCL10	inhibits	gene	0.60
CCL3	expressed_in	gene	0.60
CCR1	expressed_in	gene	0.60
CCR5	expressed_in	gene	0.60
CD4	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
MICROGLIA	inhibits	gene	0.60
CXCL11	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (8)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning CXCR3 in their description or question text

No additional research found

CXCR3

Understanding Entity Pages

Summary

Wiki Pages (2)

CXCR3 Gene

CXCR3 Protein

Pathway Diagram

Outgoing (133)

Incoming (71)

Targeting Hypotheses (0)

Mentioning Analyses (6)

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

Does CXCL10 inhibition compromise CNS immune surveillance during chronic treatme

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Systemic immune profiling and peripheral immune contributions to neurodegenerati

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (0)

Related Papers (0)

Debates (8)

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

Multiple participants noted the conflation of cellular dysfunction with senescen

The debate highlighted major safety concerns about blocking CXCL10, particularly

The debate revealed contradictory evidence about CD8+ T cell roles in neurodegen

How do peripheral immune system alterations influence CNS pathology and neurodeg

How do peripheral immune system alterations influence CNS pathology and neurodeg

How do peripheral immune system alterations influence CNS pathology and neurodeg

What gene expression changes in the aging mouse brain predict neurodegenerative

Related Research