gene

CXCR3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

203Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CXCR3 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, therapeutic target. Associated with ALS, Aging, Als. Connected to 113 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CXCR3
Full Name	C-X-C Motif Chemokine Receptor 3
Chromosome	Xq13.1
Protein Type	Receptor
Function	CXCR3 is a chemokine receptor that plays critical roles in immune cell trafficking and signaling:
Molecular Weight	40 kDa
Pathways	signaling: ### Ligand Binding, PI3K, MAPK pathway
UniProt ID	P49682
NCBI Gene ID	2912
Ensembl ID	ENSG00000186810
OMIM	300214
GeneCards	CXCR3
Human Protein Atlas	CXCR3
Associated Diseases	Alzheimer'S Disease, Cancer, Carcinoma, Inflammation, MULTIPLE SCLEROSIS
Interactions	CD8, CXCL10, IRF1, CCR5, CCL3, HDAC3
KG Connections	203 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CXCR3 — AlphaFold P49682 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CXCR3["CXCR3"] -->|"associated"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    CXCR3["CXCR3"] -->|"associated"| Neurodegeneration["Neurodegeneration"]
    CXCR3["CXCR3"] -->|"expressed in"| Multiple_Sclerosis["Multiple Sclerosis"]
    CXCR3["CXCR3"] -->|"associated"| Inflammation["Inflammation"]
    CXCR3["CXCR3"] -->|"associated"| Neuroinflammation["Neuroinflammation"]
    CXCR3["CXCR3"] -->|"expressed in"| Alzheimer["Alzheimer"]
    CXCL9["CXCL9"] -->|"interacts"| CXCR3["CXCR3"]
    CXCL10["CXCL10"] -->|"interacts"| CXCR3["CXCR3"]
    CXCL11["CXCL11"] -->|"interacts"| CXCR3["CXCR3"]
    CXCL10_1["CXCL10"] -->|"expressed in"| CXCR3["CXCR3"]
    style CXCR3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (129)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.70
macrophages	expressed_in	cell_type	0.70
Encephalitis	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Diabetes	contributes_to	disease	0.65
Autoimmune	contributes_to	disease	0.65
Tumor	interacts_with	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Inflammation	contributes_to	disease	0.65
Als	contributes_to	disease	0.65
Psoriasis	contributes_to	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Lymphoma	activates	disease	0.65
Inflammation	activates	disease	0.65
Ulcerative Colitis	activates	disease	0.65
Inflammatory Bowel Disease	activates	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Autoimmune	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
TH1_RESPONSE	regulates	pathway	0.64
NEUROINFLAMMATION	regulates	phenotype	0.64
LRP1	expressed_in	gene	0.60

Incoming (74)

Source	Relation	Type	Str
CXCL10	interacts_with	protein	0.72
CXCL9	interacts_with	protein	0.72
CXCL11	interacts_with	protein	0.72
CXCL10	activates	gene	0.70
CCR2	expressed_in	gene	0.70
CXCL10	expressed_in	gene	0.60
LRP1	expressed_in	gene	0.60
FOS	activates	gene	0.60
TNF	activates	gene	0.60
PI3K	activates	gene	0.60
CD14	activates	gene	0.60
STAT1	contributes_to	gene	0.60
AKT	activates	gene	0.60
BECN1	activates	gene	0.60
STAT3	activates	gene	0.60
P38	activates	gene	0.60
CD8	activates	gene	0.60
CXCL10	associated_with	entity	0.60
CCR1	inhibits	gene	0.60
CCL3	inhibits	gene	0.60
TNF	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
CCR5	inhibits	gene	0.60
HDAC3	inhibits	gene	0.60
CXCL10	inhibits	gene	0.60
CXCR4	activates	gene	0.60
CD38	activates	gene	0.60
CCL3	expressed_in	gene	0.60
CCR1	expressed_in	gene	0.60
CCR5	expressed_in	gene	0.60
CD4	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
VIRAL INFECTIONS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
C-FOS	activates	gene	0.60
IL-6	activates	gene	0.60
CXCL9	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
CXCL11	expressed_in	gene	0.60
NF-ΚB	activates	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
TNF-Α	activates	gene	0.60
CXCL9	activates	gene	0.60
ERK	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CANCER	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.692

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CXCR3

Understanding Entity Pages

Summary

Wiki Pages (13)

CXCR3 Gene

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Interferon Signaling in Neurodegeneration

cxcr4

treg-regulatory-t-cell-therapy-parkinsons

CXCR3 Protein

STAT4 Gene

Microglia CD8+ T Cell Recruitment in White Matter Degeneration

Neuroimmune Interface Pathway

Neuroinflammation in Corticobasal Degeneration

CXCL10 - C-X-C Motif Chemokine Ligand 10

Proteins