gene

DAB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DAB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

145Connections
0Hypotheses
1Analyses
50Outgoing
44Incoming

Summary

DAB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with ALS, Als, Alzheimer. Connected to 78 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDAB1
Full NameDisabled-1
Chromosome1p32-p31
Protein FamilyDisabled family
Protein TypeAdaptor Protein
Functionis a key intracellular adaptor protein in the Reelin signaling pathway.
Subcellular LocalizationCytoplasm, postsynaptic densities
Molecular Weight~80 kDa (625 amino acids)
Amino Acids625 aa
PathwaysDendritic Spine, Synaptic Plasticity
UniProt IDD3DX7A
NCBI Gene ID1600
Ensembl IDENSG00000170522
OMIM603448
GeneCardsDAB1
Human Protein AtlasDAB1
Associated DiseasesALS, Alzheimer, Autism, Bipolar, Depression
InteractionsPAFAH1B1, DCX, LIS1, CDK5, RELN, GAIN
KG Connections145 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: DAB1 — AlphaFold D3DX7A Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

DAB1 Gene

gene · 644 words

nimodipine-als

clinical_trial · 5778 words

Miller-Dieker Syndrome

disease · 3620 words

amiloride-als

clinical_trial · 3477 words

Amyotrophic Lateral Sclerosis (ALS)

disease · 3458 words

Riluzole ALS Trials

clinical · 3263 words

Pathway Diagram

graph TD
    DAB1["<b>DAB1</b>"]
    Ms{"Ms"}
    DAB1 -->|"interacts with"| Ms
    Als{"Als"}
    DAB1 -->|"interacts with"| Als
    Schizophrenia{"Schizophrenia"}
    DAB1 -->|"regulates"| Schizophrenia
    Epilepsy{"Epilepsy"}
    DAB1 -->|"regulates"| Epilepsy
    Alzheimer{"Alzheimer"}
    DAB1 -->|"regulates"| Alzheimer
    Autism{"Autism"}
    DAB1 -->|"regulates"| Autism
    Depression{"Depression"}
    DAB1 -->|"regulates"| Depression
    Bipolar{"Bipolar"}
    DAB1 -->|"regulates"| Bipolar
    DAB1 -->|"regulates"| Ms
    Neurodegeneration{"Neurodegeneration"}
    DAB1 -->|"therapeutic target"| Neurodegeneration
    DAB1 -->|"interacts with"| Schizophrenia
    Dementia{"Dementia"}
    DAB1 -->|"therapeutic target"| Dementia
    DCX["DCX"]
    DCX -->|"interacts with"| DAB1
    CDK5["CDK5"]
    CDK5 -->|"interacts with"| DAB1
    LIS1["LIS1"]
    LIS1 -->|"interacts with"| DAB1
    JUN["JUN"]
    JUN -->|"regulates"| DAB1
    PAFAH1B1["PAFAH1B1"]
    PAFAH1B1 -->|"interacts with"| DAB1
    SRC["SRC"]
    SRC -->|"associated with"| DAB1
    FYN["FYN"]
    FYN -->|"associated with"| DAB1
    CDK5 -->|"associated with"| DAB1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| DAB1
    APOE4["APOE4"]
    APOE4 -->|"associated with"| DAB1
    RELN["RELN"]
    RELN -->|"associated with"| DAB1
    CDK5 -->|"causes"| DAB1
    style DAB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (101)

TargetRelationTypeStr
Reelin Signaling Pathwaycomponent_ofpathway0.90
superficial dorsal hornexpressed_inbrain_region0.90
REELINinteracts_withentity0.85
dI5 neuron migrationmediatesprocess0.85
Reelin signaling pathwayinvolved_inpathway0.85

Incoming (44)

SourceRelationTypeStr
RELNinteracts_withprotein0.90
reelin_proteinphosphorylatesprotein0.80
DCXinteracts_withgene0.60
CDK5interacts_withgene0.60
LIS1interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Selective vulnerability of entorhinal cortex layer II neurons in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.484

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found