Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DAB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DAB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with ALS, Als, Alzheimer. Connected to 78 entities in the SciDEX knowledge graph.
| Gene Symbol | DAB1 |
| Full Name | Disabled-1 |
| Chromosome | 1p32-p31 |
| Protein Family | Disabled family |
| Protein Type | Adaptor Protein |
| Function | is a key intracellular adaptor protein in the Reelin signaling pathway. |
| Subcellular Localization | Cytoplasm, postsynaptic densities |
| Molecular Weight | ~80 kDa (625 amino acids) |
| Amino Acids | 625 aa |
| Pathways | Dendritic Spine, Synaptic Plasticity |
| UniProt ID | D3DX7A |
| NCBI Gene ID | 1600 |
| Ensembl ID | ENSG00000170522 |
| OMIM | 603448 |
| GeneCards | DAB1 |
| Human Protein Atlas | DAB1 |
| Associated Diseases | ALS, Alzheimer, Autism, Bipolar, Depression |
| Interactions | PAFAH1B1, DCX, LIS1, CDK5, RELN, GAIN |
| KG Connections | 145 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DAB1["<b>DAB1</b>"]
Ms{"Ms"}
DAB1 -->|"interacts with"| Ms
Als{"Als"}
DAB1 -->|"interacts with"| Als
Schizophrenia{"Schizophrenia"}
DAB1 -->|"regulates"| Schizophrenia
Epilepsy{"Epilepsy"}
DAB1 -->|"regulates"| Epilepsy
Alzheimer{"Alzheimer"}
DAB1 -->|"regulates"| Alzheimer
Autism{"Autism"}
DAB1 -->|"regulates"| Autism
Depression{"Depression"}
DAB1 -->|"regulates"| Depression
Bipolar{"Bipolar"}
DAB1 -->|"regulates"| Bipolar
DAB1 -->|"regulates"| Ms
Neurodegeneration{"Neurodegeneration"}
DAB1 -->|"therapeutic target"| Neurodegeneration
DAB1 -->|"interacts with"| Schizophrenia
Dementia{"Dementia"}
DAB1 -->|"therapeutic target"| Dementia
DCX["DCX"]
DCX -->|"interacts with"| DAB1
CDK5["CDK5"]
CDK5 -->|"interacts with"| DAB1
LIS1["LIS1"]
LIS1 -->|"interacts with"| DAB1
JUN["JUN"]
JUN -->|"regulates"| DAB1
PAFAH1B1["PAFAH1B1"]
PAFAH1B1 -->|"interacts with"| DAB1
SRC["SRC"]
SRC -->|"associated with"| DAB1
FYN["FYN"]
FYN -->|"associated with"| DAB1
CDK5 -->|"associated with"| DAB1
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"associated with"| DAB1
APOE4["APOE4"]
APOE4 -->|"associated with"| DAB1
RELN["RELN"]
RELN -->|"associated with"| DAB1
CDK5 -->|"causes"| DAB1
style DAB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Reelin Signaling Pathway | component_of | pathway | 0.90 |
| superficial dorsal horn | expressed_in | brain_region | 0.90 |
| REELIN | interacts_with | entity | 0.85 |
| dI5 neuron migration | mediates | process | 0.85 |
| Reelin signaling pathway | involved_in | pathway | 0.85 |
| Reelin Signalling Pathway | involved_in | pathway | 0.80 |
| lamina V | contributes_to | brain_region | 0.80 |
| cytoskeletal_stability | promotes | pathway | 0.80 |
| Ms | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Schizophrenia | regulates | disease | 0.65 |
| Epilepsy | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Autism | regulates | disease | 0.65 |
| Depression | regulates | disease | 0.65 |
| Bipolar | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| Schizophrenia | interacts_with | disease | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| ALS | causes | disease | 0.65 |
| Epilepsy | implicated_in | disease | 0.65 |
| Autism | implicated_in | disease | 0.65 |
| Bipolar | implicated_in | disease | 0.65 |
| Schizophrenia | implicated_in | disease | 0.65 |
| Depression | implicated_in | disease | 0.65 |
| Alzheimer | implicated_in | disease | 0.65 |
| Als | causes | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Dementia | activates | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| PAFAH1B1 | interacts_with | gene | 0.60 |
| FYN | associated_with | gene | 0.60 |
| SRC | associated_with | gene | 0.60 |
| DCX | interacts_with | gene | 0.60 |
| LIS1 | interacts_with | gene | 0.60 |
| CDK5 | interacts_with | gene | 0.60 |
| RELN | interacts_with | gene | 0.60 |
| DCX | associated_with | gene | 0.60 |
| LIS1 | associated_with | gene | 0.60 |
| PAFAH1B1 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| REELIN | causes | gene | 0.60 |
| REELIN | associated_with | gene | 0.60 |
| Dendritic Spine | regulates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RELN | interacts_with | protein | 0.90 |
| reelin_protein | phosphorylates | protein | 0.80 |
| DCX | interacts_with | gene | 0.60 |
| CDK5 | interacts_with | gene | 0.60 |
| LIS1 | interacts_with | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| PAFAH1B1 | interacts_with | gene | 0.60 |
| SRC | associated_with | gene | 0.60 |
| FYN | associated_with | gene | 0.60 |
| CDK5 | associated_with | gene | 0.60 |
| APOE4 | associated_with | gene | 0.60 |
| RELN | associated_with | gene | 0.60 |
| CDK5 | causes | gene | 0.60 |
| LIS1 | causes | gene | 0.60 |
| DCX | causes | gene | 0.60 |
| DYNEIN | causes | gene | 0.60 |
| PAFAH1B1 | causes | gene | 0.60 |
| REELIN | causes | gene | 0.60 |
| REELIN | associated_with | gene | 0.60 |
| FYN | implicated_in | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| RELN | activates | gene | 0.60 |
| APP | interacts_with | gene | 0.60 |
| REELIN | interacts_with | gene | 0.60 |
| CLUSTERIN | interacts_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| AXON | causes | gene | 0.60 |
| NEURON | causes | gene | 0.60 |
| MICROTUBULES | causes | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| DEPRESSION | regulates | gene | 0.60 |
| EPILEPSY | regulates | gene | 0.60 |
| EPILEPSY | implicated_in | gene | 0.60 |
| ALZHEIMER | implicated_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | implicated_in | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| APOER2 | associated_with | gene | 0.60 |
| APOER2 | activates | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| APOE3 | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| DEMENTIA | activates | gene | 0.60 |
| APOE | regulates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.484
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||