gene

GASTRODIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GASTRODIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

198Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	GASTRODIN
Primary Expression	Hippocampus
Pathways	TLR4/TRAF6/NF-κB, Oxidative Stress, Ferroptosis, Mitochondrial Function, Phagocytosis
GeneCards	GASTRODIN
Human Protein Atlas	GASTRODIN
Associated Diseases	Aging, Alzheimer, Ms
Interactions	NRF2, STAT3, TLR4, NF-ΚB, INFLAMMATION, TNF-Α
KG Connections	175 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

TNF-alpha Protein - Tumor Necrosis Factor

protein · 797 words

→

TLR4 Gene

gene · 612 words

→

Pathway Diagram

graph TD
    GASTRODIN["GASTRODIN"]
    GASTRODIN -->|"regulates"| TLR4_TRAF6_NF__B["TLR4/TRAF6/NF-kappaB"]
    GASTRODIN -->|"interacts"| KEAP1["KEAP1"]
    GASTRODIN -->|"inhibits"| ferroptosis["ferroptosis"]
    GASTRODIN -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    GASTRODIN -->|"inhibits"| Microglial_Activation["Microglial Activation"]
    GASTRODIN -->|"treats"| NAFLD["NAFLD"]
    GASTRODIN -->|"mediates"| Neuroprotection["Neuroprotection"]
    GASTRODIN -->|"target for"| Oxidative_Stress["Oxidative Stress"]
    GASTRODIN -->|"target for"| Inflammation["Inflammation"]
    STROKE["STROKE"] -->|"target for"| GASTRODIN
    APOPTOSIS["APOPTOSIS"] -->|"target for"| GASTRODIN
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"target for"| GASTRODIN
    INFLAMMATION["INFLAMMATION"] -->|"target for"| GASTRODIN
    FERROPTOSIS["FERROPTOSIS"] -->|"inhibits"| GASTRODIN
    FSP1["FSP1"] -->|"target for"| GASTRODIN
    KEAP1 -->|"inhibits"| GASTRODIN
    TLR4_TRAF6_NF__B -->|"activates"| GASTRODIN
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| GASTRODIN
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| GASTRODIN

Outgoing (148)

Target	Relation	Type	Str
TLR4/TRAF6/NF-κB	regulates	pathway	0.95
Oxidative Stress	inhibits	process	0.95
Autophagy	promotes	process	0.95
Phagocytosis	promotes	process	0.95
KEAP1	interacts_with	protein	0.90
ferroptosis	inhibits	phenotype	0.90
Microglial Activation	inhibits	process	0.90
TLR4/TRAF6/NF-ΚB	regulates	gene	0.90
Neuroinflammation	inhibits	process	0.90
PINK1	activates	gene	0.85
SQSTM1	downregulates	gene	0.85
NAFLD	treats	disease	0.85
Microglia	inhibits	cell_type	0.85
Anti-Inflammatory Effect	mediates	mechanism	0.80
Age-Related Macular Degeneration	treats	disease	0.80
Neuroprotection	mediates	phenotype	0.80
Oxidative Stress	therapeutic_target	pathway	0.80
Inflammation	therapeutic_target	disease	0.75
Stroke	therapeutic_target	disease	0.75
Oxidative Stress	protects_against	process	0.75
Alzheimer'S Disease	treats	disease	0.75
TLR4	inhibits	protein	0.70
neuroinflammation	protects_against	process	0.70
Cognitive Function	protects_against	phenotype	0.70
Memory	protects_against	phenotype	0.70
Cognitive Function	promotes	phenotype	0.70
Memory	promotes	phenotype	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
Apoptosis	therapeutic_target	pathway	0.70
Ms	therapeutic_target	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	activates	disease	0.65
Stroke	inhibits	disease	0.65
Ischemia	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	protects_against	disease	0.65
Als	protects_against	disease	0.65
Alzheimer	activates	disease	0.65
Ms	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Als	activates	disease	0.65
Macular Degeneration	activates	disease	0.65
ALS	activates	disease	0.65
Alzheimer	associated_with	disease	0.65

Incoming (50)

Source	Relation	Type	Str
STROKE	therapeutic_target	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
FSP1	therapeutic_target	gene	0.60
KEAP1	inhibits	gene	0.60
TLR4/TRAF6/NF-ΚB	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
TNF	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
NATURAL COMPOUNDS	treats	gene	0.60
NEUROTOXICITY	activates	gene	0.60
GFAP	activates	gene	0.60
NF-ΚB	activates	gene	0.60
PER	regulates	gene	0.60
SQSTM1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
INSR	activates	gene	0.60
NGF	activates	gene	0.60
ROS	protects_against	gene	0.60
ALZHEIMER	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
PPAR	activates	gene	0.60
LC3B	activates	gene	0.60
AKT	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
CDK1	therapeutic_target	gene	0.60
INOS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
STAT3	activates	gene	0.60
IL-1	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
Neuroinflammation	activates	process	0.50
TLR4	activates	gene	0.50
TRAF6	activates	gene	0.50
NF-κB	activates	concept	0.50
TFEB	activates	protein	0.50
Autophagy	activates	process	0.50
CD36	activates	gene	0.50
oxidative stress	activates	phenotype	0.50
oxidative stress	protects_against	phenotype	0.50
oxidative stress	inhibits	phenotype	0.50
disease	associated_with	disease	0.50
Pi3K	activates	pathway	0.50
Pi3K/Akt	activates	pathway	0.50
Alzheimer'S Disease	activates	disease	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found