protein

PGC-1ALPHA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGC-1ALPHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

17Outgoing

34Incoming

Summary

PGC-1α (PPARGC1A)

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🔬 Protein Info

Gene Symbol	PGC
Full Name	1ALPHA
Function	Pgc 1Α Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	PGC
Human Protein Atlas	PGC
Known Drugs/Compounds	RAPAMYCIN, TREHALOSE, COENZYME Q10, METFORMIN
Interactions	SQSTM1, RAS, TFEB, TDP-43, SOD1, ROS
KG Connections	51 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: PGC-1ALPHA — AlphaFold Q9UBX2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PGC_1ALPHA["PGC-1ALPHA"]
    PGC_1ALPHA -->|"activates"| mitochondrial_biogenesis["mitochondrial biogenesis"]
    PGC_1ALPHA -->|"activates"| nuclear_respiratory_factor_1["nuclear respiratory factor 1"]
    PGC_1ALPHA -->|"activates"| RAPAMYCIN["RAPAMYCIN"]
    PGC_1ALPHA -->|"activates"| SQSTM1["SQSTM1"]
    PGC_1ALPHA -->|"regulates"| ROS["ROS"]
    PGC_1ALPHA -->|"activates"| RAS["RAS"]
    PGC_1ALPHA -->|"activates"| TREHALOSE["TREHALOSE"]
    PGC_1ALPHA -->|"activates"| TFEB["TFEB"]
    PEROXISOME["PEROXISOME"] -->|"activates"| PGC_1ALPHA
    AMPK["AMPK"] -->|"regulates"| PGC_1ALPHA
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| PGC_1ALPHA
    LYSOSOME["LYSOSOME"] -->|"activates"| PGC_1ALPHA
    LAMP1["LAMP1"] -->|"activates"| PGC_1ALPHA
    MTOR["MTOR"] -->|"activates"| PGC_1ALPHA
    COENZYME_Q10["COENZYME Q10"] -->|"activates"| PGC_1ALPHA
    ISCHEMIA["ISCHEMIA"] -->|"activates"| PGC_1ALPHA

Outgoing (19)

Target	Relation	Type	Str
RAPAMYCIN	activates	drug	0.50
SQSTM1	activates	gene	0.50
ROS	regulates	protein	0.50
RAS	activates	gene	0.35
TREHALOSE	activates	drug	0.35
TFEB	activates	gene	0.35
SPINAL CORD	activates	brain_region	0.35
STEM CELLS	activates	cell_type	0.35
TDP-43	activates	gene	0.35
SOD1	activates	gene	0.35
SIRT1	expressed_in	gene	0.35
ROS	inhibits	protein	0.35
SIRT3	inhibits	gene	0.35
SIRT3	interacts_with	gene	0.35
ROS	activates	protein	0.35
PINK1	regulates	gene	0.35
TGF-BETA	regulates	gene	0.35

Incoming (36)

Source	Relation	Type	Str
AUTOPHAGY	activates	process	0.50
LAMP1	activates	gene	0.50
MTOR	activates	gene	0.50
COENZYME Q10	activates	drug	0.35
ISCHEMIA	activates	disease	0.35
EGFR	activates	gene	0.35
CTSD	activates	gene	0.35
MYC	activates	gene	0.35
BECN1	activates	gene	0.35
P62	activates	gene	0.35
ALS	activates	disease	0.35
PARKINSON'S DISEASE	activates	disease	0.35
NEUROBLASTOMA	activates	disease	0.35
HUNTINGTON	activates	disease	0.35
GAPDH	activates	gene	0.35
BCL2	activates	gene	0.35
METFORMIN	expressed_in	drug	0.35
AMPK	expressed_in	gene	0.35
OXIDATIVE STRESS	inhibits	process	0.35
FOXO1	inhibits	gene	0.35
FOXO1	interacts_with	gene	0.35
MITOPHAGY	regulates	process	0.35
CANCER	regulates	disease	0.35
MITOPHAGY	activates	process	0.35
NRF2	activates	gene	0.35
FIBROSIS	regulates	disease	0.35
OXIDATIVE PHOSPHORYLATION	activates	process	0.35
CANCER	activates	disease	0.35
HEPATOCELLULAR CARCINOMA	activates	disease	0.35
FERROPTOSIS	regulates	process	0.35
METFORMIN	inhibits	drug	0.35
ORGANOIDS	interacts_with	cell_type	0.35
HEPATOCELLULAR CARCINOMA	associated_with	disease	0.35
METFORMIN	therapeutic_target	drug	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PGC-1ALPHA

Understanding Entity Pages

Summary

Wiki Pages (20)

Neuroresilience Mechanisms and Evidence

coq10-neurodegeneration

rankings

Epigenetic Dysregulation in Neurodegeneration

Insulin Signaling in Parkinson's Disease

NDUFAF3 Gene

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

Mitochondria

Huntingtin Protein (HTT)

Type 3 Diabetes Hypothesis of Alzheimer's Disease

Urolithin A for Neurodegeneration

Japanese Neurodegeneration Biotech Companies

epigenetics-neurodegeneration

WNT7A Gene

chromatin-remodeling-neurodegeneration

lmx1b

Cockayne Syndrome

Wnt-Beta-Catenin Signaling Dysfunction Hypothesis in Parkinson's Disease