concept

TGF-BETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGF-BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

156Connections

0Hypotheses

0Analyses

29Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	TGF-BETA
Key Genes/Proteins	APOE, IL-6, MAPK, EGFR
Related Diseases	Als, Atherosclerosis, CANCER, HEPATOCELLULAR CARCINOMA
Related Pathways	Tgf-Beta

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TGF_BETA["TGF-BETA"]
    TGF_BETA -->|"activates"| HEPATOCELLULAR_CARCINOMA["HEPATOCELLULAR CARCINOMA"]
    TGF_BETA -->|"activates"| COLORECTAL_CANCER["COLORECTAL CANCER"]
    TGF_BETA -->|"activates"| METASTASIS["METASTASIS"]
    TGF_BETA -->|"activates"| FIBROSIS["FIBROSIS"]
    TGF_BETA -->|"implicated in"| CANCER["CANCER"]
    TGF_BETA -->|"activates"| AGING["AGING"]
    TGF_BETA -->|"activates"| EGFR["EGFR"]
    TGF_BETA -->|"regulates"| FERROPTOSIS["FERROPTOSIS"]
    CYTOKINES["CYTOKINES"] -->|"regulates"| TGF_BETA
    CANCER -->|"regulates"| TGF_BETA
    TNF["TNF"] -->|"activates"| TGF_BETA
    IL_6["IL-6"] -->|"regulates"| TGF_BETA
    INFLAMMATION["INFLAMMATION"] -->|"activates"| TGF_BETA
    VEGF["VEGF"] -->|"activates"| TGF_BETA

Outgoing (30)

Target	Relation	Type	Str
Angiogenesis	correlates_with	process	0.92
PULMONARY HYPERTENSION	involved_in	entity	0.80
angiogenic properties	correlates_with	process	0.70
Als	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
APOE	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
Tgf-Beta	activates	pathway	0.60
Macrophage	inhibits	cell_type	0.60
CANCER	associated_with	disease	0.58
HEPATOCELLULAR CARCINOMA	associated_with	disease	0.44
HEPATOCELLULAR CARCINOMA	activates	disease	0.30
COLORECTAL CANCER	activates	disease	0.30
COLORECTAL CANCER	associated_with	disease	0.30
METASTASIS	activates	process	0.30
METASTASIS	associated_with	process	0.30
FIBROSIS	activates	disease	0.30
CANCER	implicated_in	disease	0.30
CANCER	activates	disease	0.30
AGING	activates	process	0.30
AGING	regulates	process	0.30
EGFR	activates	gene	0.30
FERROPTOSIS	regulates	process	0.30
ROS	regulates	protein	0.30
HEPATOCELLULAR CARCINOMA	inhibits	disease	0.30
CYTOKINES	regulates	protein	0.30
STROKE	regulates	disease	0.30
NF-KB	interacts_with	gene	0.30
AUTOPHAGY	inhibits	process	0.30

Incoming (126)

Source	Relation	Type	Str
INFLAMMATION	regulates	process	0.50
MAPK	regulates	gene	0.50
MICROGLIA	activates	cell_type	0.50
EGFR	interacts_with	gene	0.44
INFLAMMATION	associated_with	process	0.44
T CELLS	implicated_in	cell_type	0.35
BACE1	implicated_in	gene	0.35
EGFR	implicated_in	gene	0.35
APP	implicated_in	gene	0.35
COLORECTAL CANCER	inhibits	disease	0.35
ENDOTHELIAL CELLS	activates	cell_type	0.35
OXIDATIVE STRESS	regulates	process	0.35
HEPATOCELLULAR CARCINOMA	regulates	disease	0.35
EPIGENETIC REGULATION	regulates	process	0.35
NF-KB	causes	gene	0.35
MTOR	causes	gene	0.35
PI3K	causes	gene	0.35
AKT	causes	gene	0.35
STAT3	regulates	gene	0.35
HMGB1	regulates	gene	0.35
NF-KB	regulates	gene	0.35
ENDOTHELIAL CELLS	regulates	cell_type	0.35
AUTOPHAGY	activates	process	0.35
AKT	activates	gene	0.35
PARKIN	activates	gene	0.35
PINK1	activates	gene	0.35
P62	activates	gene	0.35
LC3	activates	gene	0.35
CANCER	biomarker_for	disease	0.35
MTOR	regulates	gene	0.35
NRF2	regulates	gene	0.35
MTOR	implicated_in	gene	0.35
PI3K	implicated_in	gene	0.35
AKT	implicated_in	gene	0.35
NOTCH	activates	gene	0.35
MACROPHAGES	activates	cell_type	0.35
MICROGLIA	phosphorylates	cell_type	0.35
ALZHEIMER'S DISEASE	activates	disease	0.35
APOE	regulates	gene	0.35
ATHEROSCLEROSIS	implicated_in	disease	0.35
HEART FAILURE	implicated_in	disease	0.35
IL-10	produces	gene	0.35
STEM CELLS	activates	cell_type	0.35
OXIDATIVE STRESS	expressed_in	process	0.35
INFLAMMATION	expressed_in	process	0.35
HEPATOCELLULAR CARCINOMA	expressed_in	disease	0.35
PGC-1ALPHA	regulates	gene	0.35
PD-L1	activates	gene	0.35
RAPAMYCIN	regulates	drug	0.35
FIBROBLASTS	activates	cell_type	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TGF-BETA

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

Therapeutics

Cellular Senescence in Neurodegeneration

TGF-β Signaling in Parkinson's Disease

Necroptosis Pathway in Neurodegeneration

UCHL1 (PARK5) Pathway in Parkinson's Disease

Remyelination in Neurodegeneration

Neuroinflammation Microglia

Cellular Senescence in Neurodegeneration

TLR5-Mediated Microglial Neuroinflammation Hypothesis

Neuroinflammation in Neurodegeneration

Neuroinflammation and Microglia Pathway

SMAD3 — SMAD Family Member 3

Exercise-BDNF-Mitochondrial Resilience Hypothesis

TGF-beta Signaling Pathway in Neurodegeneration

Microglia

PILRA Gene

PDIA3 - Protein Disulfide Isomerase Family A Member 3