concept

SYNAPTIC PLASTICITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC PLASTICITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1707Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SYNAPTIC PLASTICITY is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, regulates. Associated with ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 54 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SYNAPTIC PLASTICITY
Key Genes/Proteins	LRP1, NMDAR, CYP46A1
Related Diseases	EXCITOTOXICITY, DEPRESSION, AGING
Linked Hypotheses	6 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SYNAPTIC_PLASTICITY["SYNAPTIC PLASTICITY"]
    SYNAPTIC_PLASTICITY -->|"interacts"| Complement["Complement"]
    SYNAPTIC_PLASTICITY -->|"interacts"| Nf__b["Nf-Kappab"]
    BDNF["BDNF"] -->|"regulates"| SYNAPTIC_PLASTICITY
    physical_exercise["physical exercise"] -->|"regulates"| SYNAPTIC_PLASTICITY
    APOE4["APOE4"] -->|"inhibits"| SYNAPTIC_PLASTICITY
    TrkB_FL["TrkB-FL"] -->|"regulates"| SYNAPTIC_PLASTICITY
    PI3K_AKT["PI3K/AKT"] -->|"regulates"| SYNAPTIC_PLASTICITY
    PI3K_AKT_pathway["PI3K/AKT pathway"] -->|"regulates"| SYNAPTIC_PLASTICITY
    SXD["SXD"] -->|"activates"| SYNAPTIC_PLASTICITY
    epigenetic_alterations["epigenetic alterations"] -->|"regulates"| SYNAPTIC_PLASTICITY

Outgoing (198)

Target	Relation	Type	Str
EXCITOTOXICITY	causes	phenotype	0.70
DEPRESSION	treats	disease	0.70
LRP1	protects_against	gene	0.70
AGING	stabilizes	phenotype	0.70
NMDAR	activates	gene	0.70
CYP46A1	stabilizes	gene	0.70
CYP46A1	treats	gene	0.70
CYP46A1	protects_against	gene	0.70
CYP46A1	inhibits	gene	0.70
BDNF	treats	gene	0.65
CA1	causes	brain_region	0.65
COGNITIVE DECLINE	regulates	phenotype	0.65
SEMAGLUTIDE	activates	drug	0.65
BDNF	targets	gene	0.65
MINOCYCLINE	activates	drug	0.65
CREB1	interacts_with	gene	0.65
CANCER	implicated_in	disease	0.60
NMDAR	implicated_in	gene	0.60
SYNAPTIC TRANSMISSION	implicated_in	phenotype	0.60
LONG-TERM DEPRESSION	activates	phenotype	0.60
LONG-TERM DEPRESSION	treats	phenotype	0.60
OXIDATIVE PHOSPHORYLATION	implicated_in	pathway	0.55
NEUROGENESIS	associated_with	process	0.50
BRAINSTEM	associated_with	brain_region	0.50
PI3K/AKT PATHWAY	associated_with	pathway	0.50
DENTATE GYRUS	associated_with	brain_region	0.50
BDNF/TRKB SIGNALING	associated_with	pathway	0.50
AMYGDALA	associated_with	brain_region	0.50
CA3	associated_with	brain_region	0.50
METFORMIN	associated_with	drug	0.50
ENTORHINAL CORTEX	associated_with	brain_region	0.50
INSULIN SIGNALING	associated_with	pathway	0.50
CALCIUM SIGNALING	associated_with	pathway	0.50
LIPID RAFT	associated_with	organelle	0.50
MELATONIN	associated_with	drug	0.45
WNT SIGNALING	associated_with	pathway	0.45
CEREBRAL CORTEX	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
CA1	associated_with	brain_region	0.45
BERBERINE	associated_with	drug	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
PREFRONTAL CORTEX	associated_with	brain_region	0.45
BASAL GANGLIA	associated_with	brain_region	0.45
QUERCETIN	associated_with	drug	0.45
DASATINIB	associated_with	drug	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
CAMP SIGNALING	associated_with	pathway	0.45
SEMAGLUTIDE	associated_with	drug	0.45
MINOCYCLINE	associated_with	drug	0.45
STRIATUM	associated_with	brain_region	0.45

Incoming (1509)

Source	Relation	Type	Str
RELN	regulates	entity	0.95
NEURON	activates	cell_type	0.95
PGC1A	regulates	entity	0.85
MAP6	involved_in	entity	0.80
LIPID METABOLISM	contributes_to	entity	0.80
CA1	regulates	brain_region	0.70
CREB	stabilizes	gene	0.70
ALS	stabilizes	disease	0.70
CA1	treats	brain_region	0.70
HDAC3	activates	gene	0.70
FOXO3	inhibits	gene	0.70
DNMT1	protects_against	gene	0.70
CHOLESTEROL	stabilizes	phenotype	0.70
DENTATE GYRUS	activates	brain_region	0.70
NEUROINFLAMMATION	destabilizes	phenotype	0.70
INTERNEURONS	inhibits	cell_type	0.70
INTERNEURONS	produces	cell_type	0.70
INTERNEURONS	protects_against	cell_type	0.70
INTERNEURONS	activates	cell_type	0.70
NEURONS	treats	cell_type	0.70
CHOLESTEROL	inhibits	phenotype	0.70
APP	inhibits	gene	0.66
MICROGLIA	mediates	entity	0.65
NEURON	interacts_with	cell_type	0.65
NEURONS	interacts_with	cell_type	0.65
HDAC3	treats	gene	0.65
ASTROCYTE	treats	cell_type	0.65
BDNF	causes	gene	0.65
GLIOSIS	inhibits	phenotype	0.65
NEURONS	exacerbates	cell_type	0.65
BDNF	stabilizes	gene	0.65
MULTIPLE SCLEROSIS	stabilizes	disease	0.65
MELATONIN	inhibits	drug	0.65
NLRP3 INFLAMMASOME	treats	pathway	0.65
COGNITIVE DECLINE	regulates	phenotype	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
SIRT1	regulates	gene	0.65
APP	treats	gene	0.65
NEUROFIBRILLARY TANGLES	causes	phenotype	0.65
GLUTAMATE	regulates	phenotype	0.65
COGNITIVE DECLINE	activates	phenotype	0.65
NTRK2	regulates	gene	0.65
MICROGLIA	degrades	cell_type	0.65
TAU	inhibits	protein	0.65
COGNITIVE DECLINE	treats	phenotype	0.65
PARKINSON'S DISEASE	treats	disease	0.65
TDP-43	activates	gene	0.65
TDP-43	treats	gene	0.65
NEURON	produces	cell_type	0.65
CDK5	activates	gene	0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sleep Spindle-Synaptic Plasticity Enhancement	0.491	neurodegeneration	Sleep disruption as cause and consequenc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Effects of caffeine on sleep and cognition. [PMID:21531247]	Snel J, Lorist MM	Prog Brain Res	2011	1
Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808]	Kunttas-Tatli E, Bose A, Kahali B, Bisho	Genesis	2009	1
CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970]	Lu W, Kawatani K, Ren Y	Alzheimers Res Ther	2026	0
Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536]	Zheng ZW, Min PX, Luo YL, Mao XF, Zhang	Neuron	2026	0
Presynaptic P/Q calcium channel deficit promotes postsynaptic excitability remod [PMID:41932329]	Thompson SJ, Miao QL, Sonig A, Noebels J	Neuron	2026	0
Estradiol modulates neuronal network hyperexcitability in select NDD risk genes. [PMID:41757108]	Pruitt A, Yang L, Lee S, Balafkan N, Sea	bioRxiv : the preprint server	2026	0
Vitamin D supplementation and COVID-19 risk: a population-based, cohort study. [PMID:34273098]	["Oristrell J", "Oliva J", "Casado E", "	Journal of endocrinological in	2022	0
Intracellular calcium homeostasis and its dysregulation underlying epileptic sei [PMID:36403388]	Zhou X, Chen Z, Xiao L, Zhong Y, Liu Y,	Seizure	2022	0
Homeostatic plasticity and burst activity are mediated by hyperpolarization-acti [PMID:33547341]	Rátkai A, Tárnok K, Aouad HE, Micska B,	Scientific reports	2021	0
Machine learning reveals bilateral distribution of somatic L1 insertions in huma [PMID:33432196]	["Zhu X", "Zhou B", "Pattni R", "Gleason	Nature neuroscience	2021	0
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. [PMID:34381213]	["Su Z", "Zhang K", "Kappel K", "Li S",	Nature	2021	0
Prevalence and follow-up of potentially inappropriate medication and potentially [PMID:32641251]	["van Loveren F", "van Berlo-van de Laar	Journal of geriatric oncology	2021	0
Neuronal Cav3 channelopathies: recent progress and perspectives. [PMID:32638069]	Lory P, Nicole S, Monteil A	Pflugers Archiv : European jou	2020	0
Single-cell epigenomic analyses implicate candidate causal variants at inherited [PMID:33106633]	["Corces M", "Shcherbina A", "Kundu S",	Nature genetics	2020	0
Reciprocal associations between depression, anxiety and work-related injury. [PMID:31685530]	["Gerasimaviciute V", "B\u00fcltmann U",	Injury prevention : journal of	2020	0
On-surface synthesis of planar dendrimers via divergent cross-coupling reaction. [PMID:31160575]	["Li D", "Li S", "Xie Y", "Hua X", "Long	Nature communications	2019	0
STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Inf [PMID:31562212]	["Dulson S", "Watkins E", "Crossman D",	Journal of immunology (Baltimo	2019	0
Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of ep [PMID:29728119]	["Ayg\u00f6ren-P\u00fcrs\u00fcn E", "Mag	Orphanet journal of rare disea	2018	0
Predictors of Extended Length of Hospital Stay Following Surgical Repair of Cong [PMID:30171266]	["Azhar A", "Aljefri H"]	Pediatric cardiology	2018	0
Interstitial lung abnormalities and self-reported health and functional status. [PMID:29317545]	["Axelsson G", "Putman R", "Araki T", "S	Thorax	2018	0

SYNAPTIC PLASTICITY

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Atypical Parkinsonism

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

Neuroresilience Mechanisms and Evidence

Frontotemporal Dementia (FTD) Mechanistic Pathway

CBS/PSP Treatment Rankings

GRIA3 Gene

Alzheimer's Disease

nct07165106

Microglial Cells — Cell Type Hierarchy