gene

RCAN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RCAN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

94Connections

0Hypotheses

0Analyses

50Outgoing

31Incoming

Summary

RCAN1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Als, Alzheimer, Huntington's disease. Connected to 54 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RCAN1
Full Name	RCAN1
Chromosome	21q22.12
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	heart and skeletal muscle - RCAN1
Molecular Weight	28 kDa
Exons	8
Pathways	CBF Pathway
UniProt ID	P53805
NCBI Gene ID	1077
Ensembl ID	ENSG00000100097
GeneCards	RCAN1
Human Protein Atlas	RCAN1
Associated Diseases	ALS, Huntington, Huntington's disease, disease, neurodegeneration, oxidative stress
Known Drugs/Compounds	G2-115, memantine
Interactions	TNF, ERK1, NRF2, KEAP1, TAU, Gsk-3
KG Connections	94 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RCAN1 — AlphaFold P53805 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RCAN1 Gene

gene · 888 words

→

HERC3 — HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 3

gene · 2680 words

→

Neuritic Amyloid Plaques — Histomorphologic Evidence of Pathologic Synergy in AD

hypothesis · 2528 words

→

Pathway Diagram

graph TD
    RCAN1["<b>RCAN1</b>"]
    TREM2["TREM2"]
    RCAN1 -->|"upregulates"| TREM2
    calcineurin["calcineurin"]
    RCAN1 -->|"inhibits"| calcineurin
    Huntington_s_disease{"Huntington's disease"}
    RCAN1 -->|"associated with"| Huntington_s_disease
    medium_spiny_neurons["medium spiny neurons"]
    RCAN1 -->|"expressed in"| medium_spiny_neurons
    neuronal_resilience(["neuronal resilience"])
    RCAN1 -->|"regulates"| neuronal_resilience
    Alzheimer{"Alzheimer"}
    RCAN1 -->|"activates"| Alzheimer
    Als{"Als"}
    RCAN1 -->|"activates"| Als
    Ms{"Ms"}
    RCAN1 -->|"regulates"| Ms
    TNF["TNF"]
    RCAN1 -->|"activates"| TNF
    PI3K["PI3K"]
    RCAN1 -->|"associated with"| PI3K
    PP2A["PP2A"]
    RCAN1 -->|"associated with"| PP2A
    ERK1["ERK1"]
    RCAN1 -->|"activates"| ERK1
    G2_115["G2-115"]
    G2_115 -->|"inhibits"| RCAN1
    aging(["aging"])
    aging -->|"regulates"| RCAN1
    microglia["microglia"]
    microglia -->|"upregulates"| RCAN1
    ERK["ERK"]
    ERK -->|"associated with"| RCAN1
    style RCAN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (63)

Target	Relation	Type	Str
TREM2	upregulates	gene	0.80
HOS1	interacts_with	enzyme	0.80
Freezing Tolerance	regulates	phenotype	0.80
CBF Pathway	participates_in	pathway	0.80
calcineurin	inhibits	protein	0.70
medium spiny neurons	expressed_in	cell_type	0.70
neuronal resilience	regulates	process	0.70
Apoptosis	activates	pathway	0.70
Huntington's disease	associated_with	disease	0.70
Huntington's disease	regulates	disease	0.70
neurons	expressed_in	cell_type	0.70
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Ms	regulates	disease	0.65
ALS	activates	disease	0.65
TNF	activates	gene	0.60
PI3K	associated_with	gene	0.60
PP2A	associated_with	gene	0.60
ERK1	activates	gene	0.60
NRF2	activates	gene	0.60
KEAP1	activates	gene	0.60
AKT	associated_with	gene	0.60
CALCINEURIN	regulates	gene	0.60
TAU	activates	gene	0.60
Gsk-3	activates	protein	0.60
neurodegeneration	associated_with	disease	0.60
TFEB	activates	gene	0.60
DNA	activates	gene	0.60
AMPK	activates	gene	0.60
Akt	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Pi3K	associated_with	pathway	0.60
Mitochondrial Function	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
TNF-Α	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
CREB	activates	gene	0.60
ERK	associated_with	gene	0.60
ROS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
Pi3K/Akt	associated_with	pathway	0.60
Neuron	activates	cell_type	0.60
AND	activates	gene	0.60
ERK1/2	activates	gene	0.60
GSK-3Β	activates	gene	0.60
Aβ	activates	protein	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (31)

Source	Relation	Type	Str
G2-115	inhibits	drug	0.70
aging	regulates	process	0.70
microglia	upregulates	cell_type	0.70
GFAP	activates	gene	0.60
GAIN	activates	gene	0.60
ERK1	activates	gene	0.60
TAU	activates	gene	0.60
PP2A	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
NRF2	activates	gene	0.60
KEAP1	activates	gene	0.60
memantine	targets	drug	0.60
ERK	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
NF-ΚB	activates	gene	0.60
ACHE	activates	gene	0.60
GENES	expressed_in	gene	0.60
NEURON	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
TNF-Α	activates	gene	0.60
AMPK	activates	gene	0.60
ROS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
CREB	activates	gene	0.60
DNA	activates	gene	0.60
ERK1/2	activates	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
CREB	associated_with	gene	0.60
Pi3K	associated_with	pathway	0.50
PP2A	co_mentioned	gene	0.40
oxidative stress	co_mentioned	process	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RCAN1

Understanding Entity Pages

Summary

Wiki Pages (21)

RCAN1 Gene

HERC3 — HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 3

Neuritic Amyloid Plaques — Histomorphologic Evidence of Pathologic Synergy in AD

down-syndrome-alzheimers

levetiracetam-down-syndrome-ad-nct07234695

NFAT Pathway Modulator Therapy for Neurodegeneration

DYRK1B — Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B

PPP3CB Protein

PPP1CC Gene - Protein Phosphatase 1 Catalytic Subunit Gamma

Down Syndrome Neurodegeneration Pathway

APP Gene Dosage Reduction Therapy for Down Syndrome

PPP3CA (Calcineurin Aα) — Protein Phosphatase 3 Catalytic Subunit Alpha

NFAT1 Protein

Pramipexole Early Parkinson's Trial

Memantine - NMDA Antagonist for Alzheimer's Disease

RCAN1 Protein

Hippocampal CA2 Neurons in Alzheimer's Disease

Down Syndrome (Trisomy 21) Neurons

Subiculum-in-Alzheimers-Disease