concept

GSK-3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSK-3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

0Hypotheses

0Analyses

2Outgoing

43Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GSK-3
Summary	# [GSK-3β](/entities/gsk3-beta)[/entities/gsk3-beta](/entities/gsk3-beta)[1] ([Glycogen Synthase Kinase](/entities/gsk3-beta)[/entities/gsk3-beta(entities/gsk3-beta)-3 Beta) ## Introduction Gsk 3Β
Key Genes/Proteins	mTOR

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GSK_3["GSK-3"]
    GSK_3 -->|"interacts"| mTOR["mTOR"]
    GSK_3 -->|"causes"| Als["Als"]
    GSK_3 -->|"causes"| Neurodegeneration["Neurodegeneration"]
    GSK_3 -->|"causes"| Alzheimer["Alzheimer"]
    GSK_3 -->|"activates"| Depression["Depression"]
    GSK_3 -->|"inhibits"| Cancer["Cancer"]
    BCL_2["BCL-2"] -->|"causes"| GSK_3
    JNK["JNK"] -->|"interacts"| GSK_3
    BID["BID"] -->|"causes"| GSK_3
    BAD["BAD"] -->|"causes"| GSK_3
    BAX["BAX"] -->|"causes"| GSK_3
    APOPTOSIS["APOPTOSIS"] -->|"activates"| GSK_3
    TAU["TAU"] -->|"causes"| GSK_3
    AUTOPHAGY["AUTOPHAGY"] -->|"causes"| GSK_3

Outgoing (22)

Target	Relation	Type	Str
mTOR	interacts_with	protein	0.70
tau hyperphosphorylation	regulates	process	0.70

Incoming (43)

Source	Relation	Type	Str
JNK	interacts_with	gene	0.60
BID	causes	gene	0.60
BAD	causes	gene	0.60
BAX	causes	gene	0.60
TAU	causes	gene	0.60
CDK5	activates	gene	0.60
BACE1	activates	gene	0.60
AKT1	activates	gene	0.60
CAPN1	activates	gene	0.60
AKT	activates	gene	0.60
PSEN2	activates	gene	0.60
MAPT	activates	gene	0.60
SPR	interacts_with	gene	0.60
RCAN1	activates	gene	0.60
NRF2	activates	gene	0.60
KEAP1	activates	gene	0.60
TAU	activates	gene	0.60
PP2A	activates	gene	0.60
PSEN1	regulates	gene	0.60
PSEN2	regulates	gene	0.60
APP	regulates	gene	0.60
PRESENILIN-1	regulates	gene	0.60
ROCK1	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
LAMP1	regulates	gene	0.60
BCL-2	causes	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
DEPRESSION	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ROS	activates	gene	0.60
CREB	activates	gene	0.60
AMPK	activates	gene	0.60
DNA	activates	gene	0.60
ERK1/2	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
WNT	activates	gene	0.60
AMYLOID	regulates	gene	0.60
AMYLOID-BETA	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
APP/PS1	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GSK-3

Understanding Entity Pages

Wiki Pages (21)

GSK-3β

Novel Therapy Index

Alzheimer's Disease

GSK-3β in Neurodegeneration

Lithium for PSP/CBS — Phase 2 Trial

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

CBS/PSP Genetic Architecture

cortisol-tau-pathway

ROCK1 Gene

Neurofibrillary Tangles

Kinesin-1 Heavy Chain Protein

Neurotrophic Factor Signaling in Neurodegeneration

Tau Kinase Signaling Cascade in Alzheimer's Disease

GSK3B Gene - Glycogen Synthase Kinase 3 Beta

GSK3-beta Protein

GSK3B (Glycogen Synthase Kinase 3 Beta)

GSK-3β

Glycogen Synthase Kinase-3β (GSK-3β)

GLP-1 Receptor