gene

PCBP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PCBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections
0Hypotheses
0Analyses
49Outgoing
18Incoming

Summary

Poly(rC)-Binding Protein 1 - RNA-binding protein involved in mRNA stability, translation regulation, and neurodegenerative disease mechanisms

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🧬 Gene Info
Gene SymbolPCBP1
Full NamePoly(rC) Binding Protein 1
AliasesHNRNP E1, hnRNP-E1, αCP1
Chromosome2p13.3.
Functionencodes a critical RNA-binding protein involved in post-transcriptional gene regulation.
Molecular Weight~38 kDa
Amino Acids371 aa
PathwaysAkt, Pi3K
UniProt IDQ15365
NCBI Gene ID5099
Ensembl IDENSG00000131469
OMIM604213
GeneCardsPCBP1
Human Protein AtlasPCBP1
Protein Length371 amino acids
Associated DiseasesMs, Tumor
InteractionsIL6, SLC40A1, STAT1, STAT3, STAT4, TLR4
KG Connections67 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: PCBP1 — AlphaFold Q15365 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

PCBP1 Gene

gene · 2077 words

RBM25 (RNA Binding Motif 25)

gene · 1728 words

SLC40A1 Gene

gene · 1638 words

PCBP2 Protein

protein · 1404 words

PSP Liquid-Liquid Phase Separation and Biomolecular Condensates

mechanism · 1384 words

PCBP1 Protein

protein · 990 words

Pathway Diagram

graph TD
    PCBP1["<b>PCBP1</b>"]
    FERRITINH["FERRITINH"]
    PCBP1 -->|"binds"| FERRITINH
    PCBP1 -->|"regulates"| FERRITINH
    TNF["TNF"]
    PCBP1 -->|"regulates"| TNF
    IL1B["IL1B"]
    PCBP1 -->|"regulates"| IL1B
    IL6["IL6"]
    PCBP1 -->|"regulates"| IL6
    Ms{"Ms"}
    PCBP1 -->|"associated with"| Ms
    Cancer{"Cancer"}
    PCBP1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    PCBP1 -->|"associated with"| Tumor
    Als{"Als"}
    PCBP1 -->|"activates"| Als
    PI3K["PI3K"]
    PCBP1 -->|"regulates"| PI3K
    AKT["AKT"]
    PCBP1 -->|"regulates"| AKT
    FERROPTOSIS["FERROPTOSIS"]
    PCBP1 -->|"inhibits"| FERROPTOSIS
    HSP90AA1["HSP90AA1"]
    HSP90AA1 -->|"activates"| PCBP1
    ATG7["ATG7"]
    ATG7 -->|"activates"| PCBP1
    style PCBP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (49)

TargetRelationTypeStr
FERRITINHbindsprotein0.80
FERRITINHregulatesprotein0.70
TNFregulatesprotein0.70
IL1Bregulatesprotein0.70
IL6regulatesprotein0.70

Incoming (18)

SourceRelationTypeStr
HSP90AA1activatesgene0.60
ATG7activatesgene0.60
PI3Kregulatesgene0.60
TLR4expressed_ingene0.60
TXNIPexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found