Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PCBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Poly(rC)-Binding Protein 1 - RNA-binding protein involved in mRNA stability, translation regulation, and neurodegenerative disease mechanisms
| Gene Symbol | PCBP1 |
| Full Name | Poly(rC) Binding Protein 1 |
| Aliases | HNRNP E1, hnRNP-E1, αCP1 |
| Chromosome | 2p13.3. |
| Function | encodes a critical RNA-binding protein involved in post-transcriptional gene regulation. |
| Molecular Weight | ~38 kDa |
| Amino Acids | 371 aa |
| Pathways | Akt, Pi3K |
| UniProt ID | Q15365 |
| NCBI Gene ID | 5099 |
| Ensembl ID | ENSG00000131469 |
| OMIM | 604213 |
| GeneCards | PCBP1 |
| Human Protein Atlas | PCBP1 |
| Protein Length | 371 amino acids |
| Associated Diseases | Ms, Tumor |
| Interactions | IL6, SLC40A1, STAT1, STAT3, STAT4, TLR4 |
| KG Connections | 67 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PCBP1["<b>PCBP1</b>"]
FERRITINH["FERRITINH"]
PCBP1 -->|"binds"| FERRITINH
PCBP1 -->|"regulates"| FERRITINH
TNF["TNF"]
PCBP1 -->|"regulates"| TNF
IL1B["IL1B"]
PCBP1 -->|"regulates"| IL1B
IL6["IL6"]
PCBP1 -->|"regulates"| IL6
Ms{"Ms"}
PCBP1 -->|"associated with"| Ms
Cancer{"Cancer"}
PCBP1 -->|"inhibits"| Cancer
Tumor{"Tumor"}
PCBP1 -->|"associated with"| Tumor
Als{"Als"}
PCBP1 -->|"activates"| Als
PI3K["PI3K"]
PCBP1 -->|"regulates"| PI3K
AKT["AKT"]
PCBP1 -->|"regulates"| AKT
FERROPTOSIS["FERROPTOSIS"]
PCBP1 -->|"inhibits"| FERROPTOSIS
HSP90AA1["HSP90AA1"]
HSP90AA1 -->|"activates"| PCBP1
ATG7["ATG7"]
ATG7 -->|"activates"| PCBP1
style PCBP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| FERRITINH | binds | protein | 0.80 |
| FERRITINH | regulates | protein | 0.70 |
| TNF | regulates | protein | 0.70 |
| IL1B | regulates | protein | 0.70 |
| IL6 | regulates | protein | 0.70 |
| Ms | associated_with | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Ferroptosis | activates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| PI3K | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| NRF2 | expressed_in | gene | 0.60 |
| STAT3 | expressed_in | gene | 0.60 |
| STAT4 | expressed_in | gene | 0.60 |
| MYD88 | expressed_in | gene | 0.60 |
| NQO1 | expressed_in | gene | 0.60 |
| JAK2 | expressed_in | gene | 0.60 |
| STAT1 | expressed_in | gene | 0.60 |
| GPX4 | expressed_in | gene | 0.60 |
| IL6 | activates | gene | 0.60 |
| KEAP1 | expressed_in | gene | 0.60 |
| SLC40A1 | inhibits | gene | 0.60 |
| STAT1 | inhibits | gene | 0.60 |
| STAT3 | inhibits | gene | 0.60 |
| STAT4 | inhibits | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| ferroptosis | participates_in | pathway | 0.60 |
| FERROPTOSIS | inhibits | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| Akt | regulates | pathway | 0.60 |
| Ferroptosis | inhibits | pathway | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Pi3K | regulates | pathway | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| ROS | activates | gene | 0.60 |
| GSH | activates | gene | 0.60 |
| HO-1 | expressed_in | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| Inflammasome | activates | pathway | 0.60 |
| Nf-Κb | expressed_in | pathway | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| JAK-STAT signaling | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HSP90AA1 | activates | gene | 0.60 |
| ATG7 | activates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| TLR4 | expressed_in | gene | 0.60 |
| TXNIP | expressed_in | gene | 0.60 |
| SLC40A1 | expressed_in | gene | 0.60 |
| ASC | expressed_in | gene | 0.60 |
| NLRP3 | expressed_in | gene | 0.60 |
| JAK1 | expressed_in | gene | 0.60 |
| ASC | inhibits | gene | 0.60 |
| GPX4 | inhibits | gene | 0.60 |
| JAK1 | inhibits | gene | 0.60 |
| JAK2 | inhibits | gene | 0.60 |
| NLRP3 | inhibits | gene | 0.60 |
| NQO1 | inhibits | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| COX2 | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||