Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CGAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CGAS is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, interacts with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 1017 entities in the SciDEX knowledge graph.
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| Gene Symbol | CGAS |
| Chromosome | 6q15 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | Small molecule inhibitor of cyclic dinucleotide synthesis |
| Mechanism of Action | Small molecule inhibitor of cyclic dinucleotide synthesis |
| Druggability | Medium (0.47) |
| Clinical Stage | Phase III |
| Molecular Weight | 57 kDa |
| Amino Acids | 522 aa |
| Exons | 8 |
| Pathways | Akt, Amyloid, Apoptosis, Autophagy, Calcium Signaling |
| UniProt ID | Q8N884 |
| NCBI Gene ID | 115004 |
| Ensembl ID | ENSG00000154122 |
| GeneCards | CGAS |
| Human Protein Atlas | CGAS |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | Aberrant DNA, RAPAMYCIN, mtDNA, cGAS Inhibitors, Ginkgetin, Mitochondrial Dna |
| Interactions | STING1, DNASE2, PARP1, IRF3, SQSTM1, RPS6KB1 |
| SciDEX Target | View Target Profile (4 clinical trials) |
| KG Connections | 1981 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CGAS["CGAS"] -->|"activates"| STING["STING"]
CGAS["CGAS"] -->|"activates"| NFKB["NFKB"]
CGAS["CGAS"] -->|"activates"| IFN["IFN"]
CGAS["CGAS"] -->|"mediates"| NEURODEGENERATION["NEURODEGENERATION"]
CGAS["CGAS"] -->|"associated"| neurodegeneration["neurodegeneration"]
CGAS["CGAS"] -->|"interacts"| STING1["STING1"]
MITOCHONDRIAL_DNA["MITOCHONDRIAL_DNA"] -->|"activates"| CGAS["CGAS"]
MTDNA["MTDNA"] -->|"activates"| CGAS["CGAS"]
TDP43["TDP43"] -->|"activates"| CGAS["CGAS"]
STING1_1["STING1"] -->|"interacts"| CGAS["CGAS"]
style CGAS fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| STING | activates | protein | 1.00 |
| STING | inhibits | gene | 1.00 |
| STING | therapeutic_target | gene | 1.00 |
| IFN | activates | protein | 1.00 |
| Tumor | activates | disease | 1.00 |
| Innate Immunity | activates | pathway | 1.00 |
| Als | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Autoimmune | activates | disease | 1.00 |
| DNA | activates | gene | 1.00 |
| MTDNA | activates | gene | 1.00 |
| Als | inhibits | disease | 1.00 |
| Innate Immunity | regulates | pathway | 1.00 |
| Senescence | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| CGAS-STING | inhibits | gene | 1.00 |
| CGAS-STING | activates | gene | 1.00 |
| CGAS-STING | implicated_in | gene | 1.00 |
| Infection | activates | disease | 1.00 |
| STING | regulates | gene | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| GENES | activates | gene | 1.00 |
| CGAS-STING | associated_with | gene | 1.00 |
| CGAS-STING | therapeutic_target | gene | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Immune Response | causes | pathway | 1.00 |
| cGAMP | produces | protein | 0.95 |
| Type I Interferon Expression | activates | process | 0.95 |
| Cytosolic DNA | associated_with | process | 0.95 |
| DNA Repair | inhibits | process | 0.95 |
| Tumorigenesis | associated_with | process | 0.95 |
| Intracellular DNA Sensing | mediates | process | 0.95 |
| Cytosolic DNA | binds | biomarker | 0.95 |
| Innate Immune System | involved_in | process | 0.95 |
| Intracellular Dna Sensing | involved_in | process | 0.95 |
| Aberrant DNA | binds | compound | 0.95 |
| 2'3'-cGAMP | produces | compound | 0.95 |
| Lysosome Biogenesis | upregulates | process | 0.95 |
| 2'3'-Cgamp | associated_with | compound | 0.95 |
| Aging | activates | disease | 0.95 |
| Als | associated_with | disease | 0.95 |
| Carcinoma | activates | disease | 0.95 |
| Inflammation | regulates | disease | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| mitochondrial DNA | activates | protein | 1.00 |
| TOLLIP | inhibits | protein | 1.00 |
| dsDNA | activates | gene | 1.00 |
| STING | activates | gene | 1.00 |
| TBK1 | activates | gene | 1.00 |
| IRF3 | activates | gene | 1.00 |
| DNA | activates | protein | 1.00 |
| GENES | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| DSDNA | activates | gene | 1.00 |
| MITOCHONDRIAL DNA | activates | gene | 1.00 |
| NLRP3 | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| cytosolic DNA | activates | protein | 0.95 |
| Mitochondrial DNA Release | activates | process | 0.95 |
| UL21 | promotes_degradation_of | protein | 0.95 |
| cytosolic DNA | activates | phenotype | 0.95 |
| MTDNA | activates | protein | 0.94 |
| UBE3C | catalyzes_ubiquitination_of | protein | 0.93 |
| UL21 | inhibits | protein | 0.90 |
| mtDNA Release | activates | process | 0.90 |
| UBE3C | modifies | protein | 0.90 |
| h-1a34778f | targets_gene | hypothesis | 0.90 |
| h-bbe4540f | targets_gene | hypothesis | 0.90 |
| STING | activates | gene | 0.90 |
| Mitochondrial DNA | activates | compound | 0.90 |
| CGAS | encodes | gene | 0.90 |
| APOPTOSIS | activates | gene | 0.90 |
| AUTOPHAGY | regulates | gene | 0.90 |
| FERROPTOSIS | activates | gene | 0.90 |
| NF-ΚB | regulates | gene | 0.90 |
| PYROPTOSIS | activates | gene | 0.90 |
| NEUROINFLAMMATION | activates | gene | 0.90 |
| self-DNA | activates | gene | 0.85 |
| FGF21 | inhibits | protein | 0.85 |
| APOE | upregulates | gene | 0.85 |
| APOE | upregulates | gene | 0.85 |
| Tetrahydroxy Stilbene Glucoside | downregulates | compound | 0.85 |
| nuclear localization | modulates | phenotype | 0.85 |
| self-DNA | activates | protein | 0.85 |
| Mitochondrial Dna | activates | compound | 0.85 |
| Mitochondrial Dna | activates | compound | 0.85 |
| endogenous DNA | activates | gene | 0.80 |
| PQBP1 | activates | gene | 0.80 |
| h-1a34778f | targets | hypothesis | 0.80 |
| Mitochondrial Dna | binds | compound | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| cGAS-STING Senescence Circuit Disruption | 0.691 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 0 hypotheses
neuroinflammation | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-03 | 37 hypotheses Top: 0.990
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.934
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| cGAS/STING pathway activation by TDP-43-released mtDNA | exploratory | amyotrophic lateral sclerosis | 0.950 | 0.00 | iPSC-derived motor neurons | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960] | Fazal F, Dar NJ, Ahamad S, Khan S, Bano | Mol Aspects Med | 2026 | 0 |
| cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960] | Fazal F, Dar NJ, Ahamad S, Khan S, Bano | Mol Aspects Med | 2026 | 0 |
| Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397] | Lu C, Wang W, Fu YX | Nat Rev Cancer | 2026 | 0 |
| Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397] | Lu C, Wang W, Fu YX | Nat Rev Cancer | 2026 | 0 |
| Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200] | Li D, Cui G, Yang K, Lu C, Jiang Y et al | Nat Cell Biol | 2026 | 0 |
| Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200] | Li D, Cui G, Yang K, Lu C, Jiang Y et al | Nat Cell Biol | 2026 | 0 |
| cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413] | Solomon J, Mandal S, Aran KR | Gene | 2026 | 0 |
| cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413] | Solomon J, Mandal S, Aran KR | Gene | 2026 | 0 |
| Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867] | Li L, Ye Q, Ma J, Wang Z, Liu T et al. | Cancer Cell | 2026 | 0 |
| Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867] | Li L, Ye Q, Ma J, Wang Z, Liu T et al. | Cancer Cell | 2026 | 0 |
| DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic [PMID:41610251] | Tomaskovic I, Prieto-Garcia C, Boskovic | Science | 2026 | 0 |
| DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic [PMID:41610251] | Tomaskovic I, Prieto-Garcia C, Boskovic | Science | 2026 | 0 |
| Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081] | Qin H, Yang L, Du J, Xu X, Chen Z et al. | Int Immunopharmacol | 2026 | 0 |
| Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081] | Qin H, Yang L, Du J, Xu X, Chen Z et al. | Int Immunopharmacol | 2026 | 0 |
| Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243] | Zhang M, Lan Y, Yue Q, He J, Li L et al. | J Nanobiotechnology | 2026 | 0 |
| Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243] | Zhang M, Lan Y, Yue Q, He J, Li L et al. | J Nanobiotechnology | 2026 | 0 |
| STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053] | Ye R, Wang S, Hu Y, Pan Y, Zheng W et al | Science | 2026 | 0 |
| STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053] | Ye R, Wang S, Hu Y, Pan Y, Zheng W et al | Science | 2026 | 0 |
Multi-agent debates referencing this entity