SciDEX — NRF2 PATHWAY

Target	Relation	Type	Str
INFLAMMATION	inhibits	phenotype	0.65
FERROPTOSIS	protects_against	phenotype	0.65
APOPTOSIS	inhibits	phenotype	0.65
ROS	treats	phenotype	0.65
CHOLESTEROL	interacts_with	phenotype	0.65
AUTOPHAGY	causes	phenotype	0.65
CELL DEATH	associated_with	phenotype	0.50
MAPK	associated_with	gene	0.50
GLUTAMATE	associated_with	phenotype	0.50
SLC1A2	associated_with	gene	0.50
CYP46A1	associated_with	gene	0.50
HO-1	associated_with	gene	0.45
STROKE	associated_with	disease	0.45
FERROPTOSIS	associated_with	phenotype	0.45
PI3K	associated_with	gene	0.45
MICROGLIA	associated_with	cell_type	0.45
NLRP3	associated_with	gene	0.45
PRAMIPEXOLE	associated_with	drug	0.45
SOD1	associated_with	gene	0.45
MEMANTINE	associated_with	drug	0.45
MELATONIN	associated_with	drug	0.45
CHOLESTEROL	associated_with	phenotype	0.45
HDAC3	associated_with	gene	0.45
AKT	associated_with	gene	0.45
ROS	associated_with	phenotype	0.45
ISCHEMIA	associated_with	disease	0.45
SUPEROXIDE	associated_with	phenotype	0.45
ASTROCYTE	associated_with	cell_type	0.45
APP	associated_with	gene	0.45
SIRT1	associated_with	gene	0.45
STAT3	associated_with	gene	0.45
TGFB1	associated_with	gene	0.45
MITOPHAGY	associated_with	phenotype	0.45
AMPK	associated_with	gene	0.45
CORTEX	associated_with	brain_region	0.45
NRF2	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
ERK	associated_with	gene	0.45
CREB	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
KEAP1	associated_with	gene	0.45
PARKINSON	associated_with	disease	0.45
AUTOPHAGY	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45

Source	Relation	Type	Str
SQSTM1	interacts_with	gene	0.91
Oxidative Stress	inhibits	process	0.90
Memantine	activates	drug	0.80
Epigallocatechin Gallate	targets	compound	0.80
CYP46A1	regulates	gene	0.70
CYP46A1	inhibits	gene	0.70
SIRT1	regulates	gene	0.65
APOPTOSIS	regulates	phenotype	0.65
MELATONIN	activates	drug	0.65
ROS	activates	phenotype	0.65
STROKE	inhibits	disease	0.65
FERROPTOSIS	regulates	phenotype	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
ISCHEMIA	activates	disease	0.65
ISCHEMIA	regulates	disease	0.65
MULTIPLE SCLEROSIS	activates	disease	0.65
STROKE	activates	disease	0.65
MITOCHONDRIAL DYSFUNCTION	activates	phenotype	0.65
DIMETHYL FUMARATE	activates	drug	0.65
NRF2	treats	gene	0.65
NRF2	targets	gene	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
ASTROCYTE	targets	cell_type	0.65
ASTROCYTES	inhibits	cell_type	0.65
ASTROCYTES	regulates	cell_type	0.65
ASTROCYTE	activates	cell_type	0.65
NRF2	activates	gene	0.65
ASTROCYTES	interacts_with	cell_type	0.65
NRF2	implicated_in	gene	0.55
MITOCHONDRIAL DYSFUNCTION	associated_with	phenotype	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
PARKINSON'S DISEASE	associated_with	disease	0.45
INFLAMMATION	associated_with	phenotype	0.45
OLIGODENDROCYTES	associated_with	cell_type	0.45
OLIGODENDROCYTE	associated_with	cell_type	0.45
NEURODEGENERATION	associated_with	disease	0.45
ENDOTHELIAL CELLS	associated_with	cell_type	0.45
DIMETHYL FUMARATE	associated_with	drug	0.45

Name	NRF2 PATHWAY
Key Genes/Proteins	AKT, AMPK, APP, CREB, CYP46A1, ERK
Related Diseases	APOPTOSIS, AUTOPHAGY, CELL DEATH, CHOLESTEROL

NRF2 PATHWAY