concept

RUBCNL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RUBCNL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

303Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	RUBCNL
Key Genes/Proteins	RIPK1, BECN1, STX17, ULK1, ATG
Related Diseases	Mesenchymal Stem Cell Survival
Related Pathways	autophagy pathway, TNF Signaling

Wiki Pages (1)

Knowledge base pages for this entity

RUBCN Gene

gene · 790 words

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Pathway Diagram

graph TD
    RUBCNL["RUBCNL"]
    style RUBCNL fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    RUBCNL -->|"interacts"| RIPK1([RIPK1])
    RUBCNL -.->|"protects against"| Mesenchymal_Stem_Cell_Survival(Mesenchymal Stem Cell Survival)
    RUBCNL -->|"regulates"| Autophagy["Autophagy"]
    RUBCNL -.->|"inhibits"| Necroptosis["Necroptosis"]
    RUBCNL -.->|"inhibits"| Apoptosis["Apoptosis"]
    RUBCNL -.->|"inhibits"| TNF_Signaling["TNF Signaling"]
    RUBCNL -->|"interacts"| BECN1([BECN1])
    RUBCNL -->|"interacts"| Tumor["Tumor"]
    Histone_H3_Lysine_18_Lactylati["Histone H3 Lysine 18 Lactylation"] -->|"upregulates"| RUBCNL
    LYSOSOME([LYSOSOME]) -->|"regulates"| RUBCNL
    HTRA2([HTRA2]) -->|"interacts"| RUBCNL
    LC3([LC3]) -->|"interacts"| RUBCNL
    PLIN2([PLIN2]) -->|"interacts"| RUBCNL
    LAMP2([LAMP2]) -->|"interacts"| RUBCNL
    STX17([STX17]) -->|"interacts"| RUBCNL
    PPARA([PPARA]) -->|"interacts"| RUBCNL
    RAS([RAS]) -->|"interacts"| RUBCNL
    NR1H3([NR1H3]) -->|"interacts"| RUBCNL

Outgoing (142)

Target	Relation	Type	Str
RIPK1	interacts_with	protein	0.95
Mesenchymal Stem Cell Survival	protects_against	phenotype	0.91
autophagy pathway	participates_in	pathway	0.90
Autophagy	regulates	process	0.90
Necroptosis	inhibits	process	0.90
Apoptosis	inhibits	process	0.90
RIPK1	inhibits	protein	0.90
TNF Signaling	inhibits	pathway	0.88
Autophagy	activates	process	0.85
BECN1	interacts_with	protein	0.85
STX17	activates	gene	0.80
ULK1	activates	gene	0.80
SIRT1	activates	gene	0.70
SNAP29	activates	gene	0.70
SQSTM1	activates	gene	0.70
TFEB	activates	gene	0.70
TP53	activates	gene	0.70
VAMP8	activates	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	activates	disease	0.65
Als	interacts_with	disease	0.65
Necroptosis	regulates	disease	0.65
Tumor	activates	disease	0.65
ALS	interacts_with	disease	0.65
Inflammation	regulates	disease	0.65
AND	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
CREB	associated_with	gene	0.60
P62	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
TP53	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
ATG	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60

Incoming (161)

Source	Relation	Type	Str
Histone H3 Lysine 18 Lactylation	upregulates	process	0.90
ATG	activates	gene	0.80
BECN1	activates	gene	0.80
LC3	activates	gene	0.80
MTOR	activates	gene	0.80
rapamycin	targets	drug	0.80
AMPK	activates	gene	0.70
CREB	activates	gene	0.70
MAP1LC3	activates	gene	0.70
RB1	activates	gene	0.70
RB1CC1	activates	gene	0.70
LAMP2	activates	gene	0.70
RAS	activates	gene	0.70
LC3	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
STX17	associated_with	gene	0.60
ACAT1	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
RB1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
ACETYL-COA	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
P53	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
GSK3	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
RAS	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
GABARAPL1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found