Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAPTOR is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, regulates. Associated with Als, Cancer, Carcinoma. Connected to 67 entities in the SciDEX knowledge graph.
| Gene Symbol | RAPTOR |
| Full Name | Regulatory Associated Protein of mTORC1 |
| Aliases | Raptor protein |
| Chromosome | 17q1.32 |
| Function | RAPTOR (Regulatory-Associated Protein of mTOR) is an essential component of mTOR Complex 1 (mTORC1), serving as a scaffolding protein that recruits substrates to the mTOR kinase. |
| Primary Expression | the nervous system: - High expression: Cerebral cortex, hippocampus, basal forebrain - Mo |
| Molecular Weight | 149 kDa |
| Pathways | mtor, mTOR, PI3K, AMPK |
| UniProt ID | Q8N122 |
| Ensembl ID | ENSG00000141551 |
| GeneCards | RAPTOR |
| Human Protein Atlas | RAPTOR |
| Associated Diseases | neurodegeneration |
| Interactions | SNCA, ATG5, RHEB, MTOR, Rb, TBK1 |
| KG Connections | 111 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAPTOR["<b>RAPTOR</b>"]
axonal_regeneration(["axonal regeneration"])
RAPTOR -->|"regulates"| axonal_regeneration
mTORC1["mTORC1"]
RAPTOR -->|"interacts with"| mTORC1
Ms{"Ms"}
RAPTOR -->|"activates"| Ms
Parkinson{"Parkinson"}
RAPTOR -->|"activates"| Parkinson
Hepatitis{"Hepatitis"}
RAPTOR -->|"expressed in"| Hepatitis
Cancer{"Cancer"}
RAPTOR -->|"expressed in"| Cancer
Carcinoma{"Carcinoma"}
RAPTOR -->|"expressed in"| Carcinoma
Cirrhosis{"Cirrhosis"}
RAPTOR -->|"expressed in"| Cirrhosis
RAPTOR -->|"expressed in"| Ms
Tumor{"Tumor"}
RAPTOR -->|"regulates"| Tumor
RAPTOR -->|"inhibits"| Cancer
RAPTOR -->|"inhibits"| Tumor
AMPK["AMPK"]
AMPK -->|"activates"| RAPTOR
SNCA["SNCA"]
SNCA -->|"activates"| RAPTOR
MTOR["MTOR"]
MTOR -->|"regulates"| RAPTOR
P62["P62"]
P62 -->|"regulates"| RAPTOR
ULK1["ULK1"]
ULK1 -->|"regulates"| RAPTOR
CANCER["CANCER"]
CANCER -->|"expressed in"| RAPTOR
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"regulates"| RAPTOR
MTOR -->|"inhibits"| RAPTOR
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"inhibits"| RAPTOR
MTORC1["MTORC1"]
MTORC1 -->|"inhibits"| RAPTOR
CANCER -->|"inhibits"| RAPTOR
AUTOPHAGY -->|"inhibits"| RAPTOR
style RAPTOR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| axonal regeneration | regulates | process | 0.70 |
| mTORC1 | interacts_with | protein | 0.70 |
| Ms | activates | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Hepatitis | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Carcinoma | expressed_in | disease | 0.65 |
| Cirrhosis | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Renal Cell Carcinoma | therapeutic_target | disease | 0.65 |
| Lymphoma | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| MTORC1 | activates | protein | 0.64 |
| SNCA | activates | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| ATG5 | inhibits | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| RICTOR | expressed_in | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| MTOR | expressed_in | gene | 0.60 |
| RHEB | interacts_with | gene | 0.60 |
| MTOR | interacts_with | gene | 0.60 |
| RHEB | activates | gene | 0.60 |
| MTOR | regulates | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| TBK1 | activates | gene | 0.60 |
| USP9X | interacts_with | gene | 0.60 |
| Mtor | activates | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Mtor | regulates | pathway | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| Mtor | inhibits | pathway | 0.60 |
| ALPHA-SYNUCLEIN | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Alpha-Synuclein | activates | pathway | 0.60 |
| ACETYL-COA | activates | gene | 0.60 |
| ATP | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SNCA | activates | gene | 0.60 |
| MTOR | regulates | gene | 0.60 |
| P62 | regulates | gene | 0.60 |
| ULK1 | regulates | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| UBIQUITIN | inhibits | gene | 0.60 |
| MLST8 | regulates | gene | 0.60 |
| ATG5 | inhibits | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| MTORC1 | inhibits | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| ATP | activates | gene | 0.60 |
| ACETYL-COA | activates | gene | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| MTORC1 | activates | gene | 0.60 |
| ALPHA-SYNUCLEIN | activates | gene | 0.60 |
| MTORC1 | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| RAS | interacts_with | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| LYSOSOME | inhibits | gene | 0.60 |
| LKB1 | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| ACLY | activates | gene | 0.60 |
| MTORC1 | methylates | gene | 0.60 |
| AUTOPHAGY | methylates | gene | 0.60 |
| P300 | regulates | protein | 0.56 |
| PARKIN | co_discussed | gene | 0.50 |
| NEURON | co_discussed | gene | 0.50 |
| Autophagy | activates | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||