MLST8

Understanding Entity Pages

This page aggregates everything SciDEX knows about MLST8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

MLST8 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, expressed in. Associated with ALS, Als, Cancer. Connected to 129 entities in the SciDEX knowledge graph.

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flowchart TD
    MLST8["MLST8<br/>mTOR Complex<br/>Component"]
    MTOR["MTOR<br/>Mechanistic Target<br/>of Rapamycin"]
    RICTOR["RICTOR<br/>mTORC2<br/>Component"]
    
    mTORC1["mTORC1<br/>Complex"]
    mTORC2["mTORC2<br/>Complex"]
    
    AKT_pathway["AKT<br/>Signaling"]
    PI3K_pathway["PI3K<br/>Pathway"]
    Autophagy["Autophagy<br/>Regulation"]
    
    FIP200["FIP200<br/>Autophagy<br/>Initiator"]
    AMBRA1["AMBRA1<br/>Autophagy<br/>Regulator"]
    PIK3C3["PIK3C3<br/>VPS34<br/>Kinase"]
    
    EGFR["EGFR<br/>Growth Factor<br/>Receptor"]
    STAT3["STAT3<br/>Transcription<br/>Factor"]
    
    ALS["ALS<br/>Amyotrophic<br/>Lateral Sclerosis"]
    MS["Multiple<br/>Sclerosis"]
    Neurodegeneration["Neuronal<br/>Death"]
    
    MLST8 --|"stabilizes"|--> MTOR
    MLST8 --|"essential for"|--> mTORC1
    MLST8 --|"essential for"|--> mTORC2
    MTOR --> mTORC1
    MTOR --> mTORC2
    RICTOR --> mTORC2
    
    mTORC1 --|"inhibits"|--> Autophagy
    mTORC2 --|"activates"|--> AKT_pathway
    PI3K_pathway --|"upstream"|--> AKT_pathway
    
    Autophagy --|"involves"|--> FIP200
    Autophagy --|"involves"|--> AMBRA1
    Autophagy --|"involves"|--> PIK3C3
    
    EGFR --|"activates"|--> PI3K_pathway
    AKT_pathway --|"activates"|--> STAT3
    
    MLST8 --|"dysregulated in"|--> ALS
    MLST8 --|"dysregulated in"|--> MS
    ALS --> Neurodegeneration
    MS --> Neurodegeneration
    
    style MLST8 fill:#006494
    style Autophagy fill:#1b5e20
    style AKT_pathway fill:#1b5e20
    style PI3K_pathway fill:#1b5e20
    style mTORC1 fill:#4a1a6b
    style mTORC2 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style RICTOR fill:#4a1a6b
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Neurodegeneration fill:#5d4400