gene

TET2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TET2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

636Connections

3Hypotheses

4Analyses

50Outgoing

50Incoming

10Experiments

Summary

TET2 (Tet Methylcytosine Dioxygenase 2): epigenetic regulator involved in DNA demethylation, 5-hydroxymethylcytosine formation, and linked to Alzheimer's disease, Parkinson's disease, and neurodegeneration.

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🧬 Gene Info

Gene Symbol	TET2
Full Name	Tet Methylcytosine Dioxygenase 2
Chromosome	4q24
Protein Family	TET family (Fe(II) and 2-oxoglutarate-dependent dioxygenases)
Protein Type	Epigenetic Regulator
Target Class	Epigenetic Regulator
Function	Small molecule enhancers of TET2 enzymatic activity or cofactor supplementation
Mechanism of Action	Small molecule enhancers of TET2 enzymatic activity or cofactor supplementation
Druggability	Low (0.42)
Clinical Stage	Phase II
Amino Acids	236 aa
Pathways	Amyloid, DNA_methylation, Epigenetic, Innate Immunity
UniProt ID	A7E237
NCBI Gene ID	93190
Ensembl ID	ENSG00000168769
OMIM	606839
GeneCards	TET2
Human Protein Atlas	TET2
Associated Diseases	AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE
Known Drugs/Compounds	nicotinamide
Interactions	TP53, DNMT3A, U2AF1, ASXL1, SF3B1, PSEN1
SciDEX Target	View Target Profile (6 clinical trials)
SciDEX Hypotheses	Epigenetic Memory Erasure via TET2 Activation TET2-Mediated Demethylation Rejuvenation Therapy Temporal TET2-Mediated Hydroxymethylation Cycling
KG Connections	635 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TET2 — AlphaFold A7E237 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TET2["TET2"]
    TET2 -->|"regulates"| DNA_methylation["DNA_methylation"]
    TET2 -->|"expressed in"| _middle_temporal_gyrus__spiny_["'middle temporal gyrus'_spiny_L3"]
    TET2 -->|"expressed in"| _middle_temporal_gyrus__aspiny["'middle temporal gyrus'_aspiny_L3"]
    TET2 -->|"activates"| Als["Als"]
    TET2 -->|"regulates"| Inflammation["Inflammation"]
    TET2 -->|"contributes to"| Cancer["Cancer"]
    TET2 -->|"contributes to"| Ms["Ms"]
    h_d2722680["h-d2722680"] -->|"target for"| TET2
    h_d7121bcc["h-d7121bcc"] -->|"target for"| TET2
    h_a90e2e89["h-a90e2e89"] -->|"target for"| TET2
    ASXL1["ASXL1"] -->|"activates"| TET2
    SF3B1["SF3B1"] -->|"activates"| TET2
    MYC["MYC"] -->|"expressed in"| TET2
    DNMT3A["DNMT3A"] -->|"activates"| TET2

Outgoing (383)

Target	Relation	Type	Str
Myeloid Cells	expressed_in	cell_type	0.95
CAR T Cell Expansion	inhibits	process	0.95
Hematopoiesis	regulates	process	0.95
Myelopoiesis	regulates	process	0.95
5-Hydroxymethylcytosine	regulates	compound	0.95
Epigenetics	involved_in	process	0.95
Clonal Hematopoiesis	involved_in	process	0.95
Alzheimer's Disease	protects_against	disease	0.95
BATF3	protects_against	gene	0.95
Hematological Malignancies	contributes_to	disease	0.90
Innate Immune Homeostasis	regulates	process	0.90
Epigenetic Regulation	mediates	mechanism	0.90
MYELOPOIESIS	regulates	entity	0.90
HEMATOLOGICAL MALIGNANCIES	associated_with	entity	0.90
GENOMIC INSTABILITY	protects_against	entity	0.90
Neuronal Morphology	modulates	phenotype	0.90
CAR T Cell Expansion	regulates	process	0.90
EPIGENETICS	involved_in	process	0.90
Car T Cell Expansion	inhibits	process	0.90
α-ketoglutarate-dependent dioxygenase activity	associated_with	phenotype	0.90
Alzheimer's Disease	associated_with	disease	0.90
INNATE IMMUNITY	regulates	entity	0.90
T CELL	regulates	entity	0.90
Alzheimer's Disease	contributes_to	disease	0.90
BATF3	regulates	gene	0.90
Alzheimer'S Disease	protects_against	disease	0.90
Tumor	implicated_in	disease	0.90
Amyloid-Beta Accumulation	inhibits	phenotype	0.88
Hematological Malignancies	associated_with	disease	0.88
BATF3	inhibits	gene	0.88
Learning and Memory	protects_against	phenotype	0.87
T Cell Memory	regulates	phenotype	0.85
Astrogliosis	inhibits	process	0.85
T CELL MEMORY	regulates	entity	0.85
LEUKAEMIA	therapeutic_target	entity	0.85
PROSTATE CANCER	therapeutic_target	entity	0.85
EPIGENETIC PROGRAMMING	involved_in	entity	0.85
Amyloid-Beta Toxicity	protects_against	process	0.85
Hippocampal Neurons	expressed_in	cell_type	0.85
Hematological Malignancies	risk_factor_for	disease	0.85
Chronic Inflammation	regulates	process	0.85
innate immune homeostasis	promotes	phenotype	0.85
Microglia Activation	inhibits	process	0.85
Phagocytosis	upregulates	process	0.85
neurons	expressed_in	cell_type	0.85
epigenetic regulation	involved_in	pathway	0.85
Immune Response	regulates	process	0.85
Hippocampal Dysfunction	biomarker_for	phenotype	0.84
PRO-INFLAMMATORY FACTORS	downregulates	protein	0.83
Neural Stem Cells	activates	cell_type	0.82

Incoming (253)

Source	Relation	Type	Str
h-d2722680	targets_gene	hypothesis	0.90
h-d7121bcc	targets_gene	hypothesis	0.90
h-a90e2e89	targets_gene	hypothesis	0.90
Arsenic	inhibits	protein	0.85
h-d2722680	targets	hypothesis	0.80
h-d7121bcc	targets	hypothesis	0.80
h-a90e2e89	targets	hypothesis	0.80
DNA	associated_with	gene	0.75
INFLAMMATION	regulates	gene	0.70
GENES	activates	gene	0.70
DNA	promotes	gene	0.70
OXIDATIVE STRESS	causes	phenotype	0.70
ALZHEIMER'S DISEASE	activates	gene	0.66
DNMT1	inhibits	gene	0.65
ASXL1	activates	gene	0.60
SF3B1	activates	gene	0.60
MYC	expressed_in	gene	0.60
DNMT3A	activates	gene	0.60
CDKN2A	expressed_in	gene	0.60
TP53	expressed_in	gene	0.60
NPM1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
TP53	therapeutic_target	gene	0.60
U2AF1	activates	gene	0.60
PSEN1	inhibits	gene	0.60
GFAP	expressed_in	gene	0.60
PSEN1	activates	gene	0.60
IL6	regulates	gene	0.60
DNMT3A	regulates	gene	0.60
CGAS	therapeutic_target	gene	0.60
JNK1	activates	gene	0.60
NLRP3	activates	gene	0.60
KMT2D	associated_with	gene	0.60
PSEN1	downregulates	entity	0.60
IBA1	expressed_in	entity	0.60
PSEN1	expressed_in	entity	0.60
CGAS	activates	gene	0.60
NLRP3	regulates	gene	0.60
FOXO3	modifies	gene	0.60
MYC	disrupts	gene	0.60
DNMT1	activates	gene	0.60
DNMT1	regulates	gene	0.60
ATM	associated_with	gene	0.60
AQP1	associated_with	gene	0.60
JAK2	regulates	gene	0.60
JAK2	translocates_to	gene	0.60
CDK6	associated_with	gene	0.60
CDKN2A	associated_with	gene	0.60
CDKN2B	associated_with	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Epigenetic Memory Erasure via TET2 Activation	0.515	neurodegeneration	Astrocyte reactivity subtypes in neurode
TET2-Mediated Demethylation Rejuvenation Therapy	0.469	neurodegeneration	Epigenetic clocks and biological aging i
Temporal TET2-Mediated Hydroxymethylation Cycling	0.408	neurodegeneration	Epigenetic reprogramming in aging neuron

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	0.00	primary mouse hippocampal neur	proposed	N/A
AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study	validation	Alzheimer's disease	0.900	0.00	young APPswe/PSEN1 double-tran	proposed	N/A
Tet2 expression analysis in aged 2×Tg-AD mouse brains	exploratory	Alzheimer's disease	0.850	0.00	APPswe/PSEN1 double-transgenic	proposed	N/A
Proposed experiment from debate on Epigenetic clocks and biological ag	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$450,000
CRISPR Gene Correction Approaches for CBS/PSP	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Epigenetic Regulation Dysfunction in Alzheimer's and Parkinson's Disea	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,500,000
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
DNA Damage Repair Deficiency Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Epigenetic Dysregulation Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Mar	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated [PMID:40929507]	Koh Y, Tengesdal IW, Jaiswal S	Annu Rev Pathol	2026	1
TET2 guards against unchecked BATF3-induced CAR T cell expansion. [PMID:36755094]	Jain N, Zhao Z, Feucht J, Koche R, Iyer	Nature	2023	1
Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Futur [PMID:36928826]	Singh I, Singh A	Curr Oncol Rep	2023	1
The function and regulation of TET2 in innate immunity and inflammation. [PMID:33085059]	Cong B, Zhang Q, Cao X	Protein Cell	2021	1
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans. [PMID:33398264]	Turner JS, Kim W, Kalaidina E, Goss CW,	Res Sq	2020	1
Reply to Rosen: Temperature-growth relationship is robust. [PMID:31375623]	Diffenbaugh NS, Burke M	Proc Natl Acad Sci U S A	2019	1
Cryo-electron microscopy structures of human oligosaccharyltransferase complexes [PMID:31831667]	Ramírez AS, Kowal J, Locher KP	Science	2019	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with [PMID:28068668]	Britschgi A, Duss S, Kim S, Couto JP, Br	Nature	2017	1
CD161 defines a transcriptional and functional phenotype across distinct human T [PMID:25437561]	Fergusson JR, Smith KE, Fleming VM, Rajo	Cell Rep	2014	1
Global epigenomic reconfiguration during mammalian brain development. [PMID:23828890]	Lister R, Mukamel EA, Nery JR, Urich M,	Science	2013	1
Genome-wide methylation profiles reveal quantitative views of human aging rates. [PMID:23177740]	Hannum G, Guinney J, Zhao L, Zhang L, Hu	Mol Cell	2013	1
TET2 in epigenetic control of immune cells: Implications for inflammatory respon [PMID:41655693]	Obrebski T, Maleszewska M, Dunin-Horkawi	The Journal of biological chem	2026	0
TET1 deficiency amplifies macrophage inflammatory signaling associated with Croh [PMID:41896302]	["Perez R", "Paul R", "Kumar P", "Tutkun	Inflammation research : offici	2026	0
Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pa [PMID:41811389]	Liu K, Hong Y, Gao Q, Huang J, Liu L, Li	Cellular and molecular life sc	2026	0
Clonal Hematopoiesis in Cardiovascular Risk: Focus on Inflammatory Mechanisms. [PMID:41899316]	["Sinnadurai S", "Honigberg M", "Meijers	Journal of clinical medicine	2026	0
Clonal Hematopoiesis and Risk of Trastuzumab-Related Cardiotoxic Effects. [PMID:41926089]	Park CS, Ryu G, Ahn HJ, Sun C, Lee SP, K	JAMA oncology	2026	0
Chimeric antigen receptor T-cell therapies related to immune effector cell-assoc [PMID:41914034]	Zhang Y, Yang J, Xin H, Ai K, Yang M, Li	Chinese medical journal	2026	0
Clonal hematopoiesis and lymphoma-associated mutations in hematopoietic progenit [PMID:41490454]	Wiegand L, Silva P, Noerenberg D, Christ	Blood	2026	0
One vs. 2 vs. ≥3 TET2 mutations in chronic myelomonocytic leukemia: co-mutation [PMID:41935083]	Yousuf M, Fathima S, Alsugair AKA, Wu SJ	Blood cancer journal	2026	0

TET2

Understanding Entity Pages

Summary

Wiki Pages (21)

TET2 Gene

Astrocyte Reactivity Mechanism

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Alterations in Alzheimer's Disease

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

DDX3X Gene

Pathway Diagram

Outgoing (383)

Incoming (253)

Targeting Hypotheses (3)

Mentioning Analyses (4)

Epigenetic reprogramming in aging neurons

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Epigenetic clocks and biological aging in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Experiments (10)

Related Papers (20)

TET2

Understanding Entity Pages

Summary

Wiki Pages (21)

TET2 Gene

Astrocyte Reactivity Mechanism

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Alterations in Alzheimer's Disease

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

DDX3X Gene

Epigenetic Mechanisms in Alzheimer's Disease

Astrocyte Metabolic Enhancement Therapy for PD

Aging vs Neurodegeneration: Mechanistic Comparison Matrix

epigenetics-neurodegeneration

Arsenic Exposure and Alzheimer's Disease Mechanism

Astrocyte Reactivity in 4R-Tauopathies

Astrocyte-Neuron Metabolic Coupling Pathway

Nicotinamide Riboside

Astrocyte-Mediated Neuroinflammation

Astrocyte Senescence Pathway in Neurodegeneration

Epigenetic Alterations in Alzheimer's Disease

5-Hydroxymethylcytosine (5-hmC) as a Biomarker for Parkinson's Disease

Cell Types

Epigenetic Regulation

Epigenetic Clocks in Brain Aging

Pathway Diagram

Outgoing (383)

Incoming (253)

Targeting Hypotheses (3)

Mentioning Analyses (4)

Epigenetic reprogramming in aging neurons

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

Epigenetic clocks and biological aging in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Experiments (10)

Related Papers (20)