gene

DNASE2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNASE2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

1Analyses

44Outgoing

27Incoming

Summary

DNASE2 is a gene implicated in neurodegeneration research. Key relationships include: co discussed, interacts with, therapeutic target. Associated with neurodegeneration. Connected to 22 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DNASE2
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitor or activator of nuclease activity
Mechanism of Action	Small molecule inhibitor or activator of nuclease activity
Druggability	Low (0.30)
Clinical Stage	Phase I
Pathways	Mitochondrial dynamics / bioenergetics
UniProt ID	O00115
GeneCards	DNASE2
Human Protein Atlas	DNASE2
Associated Diseases	Developmental delay, Glomerulonephritis, Lupus, Microcephaly, Polyarthritis, als
Known Drugs/Compounds	No specific inhibitors
Interactions	CGAS, STING1, IRF3
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	71 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DNASE2 — AlphaFold O00115 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (19)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DNASE2["DNASE2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    DNASE2["DNASE2"] -->|"interacts"| CGAS["CGAS"]
    DNASE2["DNASE2"] -->|"interacts"| STING1["STING1"]
    DNASE2["DNASE2"] -->|"co discussed"| STING1_1["STING1"]
    DNASE2["DNASE2"] -->|"co discussed"| C3["C3"]
    DNASE2["DNASE2"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    CGAS_2["CGAS"] -->|"interacts"| DNASE2["DNASE2"]
    STING1_3["STING1"] -->|"interacts"| DNASE2["DNASE2"]
    MMP9["MMP9"] -->|"co discussed"| DNASE2["DNASE2"]
    SLC7A11["SLC7A11"] -->|"co discussed"| DNASE2["DNASE2"]
    style DNASE2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (44)

Target	Relation	Type	Str
Aging	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
neurodegeneration	implicated_in	disease	0.60
Developmental delay	associated_with	disease	0.60
Microcephaly	associated_with	disease	0.60
Glomerulonephritis	associated_with	disease	0.60
Polyarthritis	associated_with	disease	0.60
GCDH	associated_with	gene	0.60
Lupus	causes	disease	0.60
T Cell	expressed_in	cell_type	0.60
Complement	expressed_in	pathway	0.60
Cell Cycle	expressed_in	pathway	0.60
Dna Repair	expressed_in	pathway	0.60
Ras	contributes_to	protein	0.60
Fus	expressed_in	protein	0.60
DNA	degrades	gene	0.60
App	expressed_in	protein	0.60
Temporal Lobe	expressed_in	brain_region	0.55
IRF3	activates	gene	0.55
neuroinflammation	activates	process	0.55
STING1	activates	gene	0.55
White Matter	expressed_in	brain_region	0.55
Mitochondrial dynamics / bioenergetics	participates_in	pathway	0.54
neurodegeneration	associated_with	disease	0.53
CGAS	interacts_with	gene	0.53
STING1	interacts_with	gene	0.53
Lupus	associated_with	disease	0.50
DNA DAMAGE	associated_with	concept	0.50
STING1	co_discussed	gene	0.40
C3	co_discussed	gene	0.40
PLA2G4A	co_discussed	gene	0.40
AQP4	co_discussed	gene	0.40
CGAS	co_discussed	gene	0.40
IL1B	co_discussed	gene	0.40
CD38	co_discussed	gene	0.40
NAMPT	co_discussed	gene	0.40
GPX4	co_discussed	gene	0.40
C1Q	co_discussed	gene	0.40
SLC7A11	co_discussed	gene	0.40
MMP2	co_discussed	gene	0.40
MMP9	co_discussed	gene	0.40
als	implicated_in	disease	0.35
ms	implicated_in	disease	0.35

Incoming (27)

Source	Relation	Type	Str
h-1a34778f	targets_gene	hypothesis	0.90
h-1a34778f	targets	hypothesis	0.80
RAD54	expressed_in	gene	0.60
DNA	associated_with	gene	0.60
DSDNA	expressed_in	gene	0.60
AND	contributes_to	gene	0.60
AND	expressed_in	gene	0.60
DNA	degrades	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
CGAS	activates	gene	0.55
CGAS	interacts_with	gene	0.53
STING1	interacts_with	gene	0.53
MMP9	co_discussed	gene	0.40
SLC7A11	co_discussed	gene	0.40
CGAS	co_discussed	gene	0.40
AQP4	co_discussed	gene	0.40
CD38	co_discussed	gene	0.40
C1Q	co_discussed	gene	0.40
NAMPT	co_discussed	gene	0.40
GPX4	co_discussed	gene	0.40
PLA2G6	co_discussed	gene	0.40
IL1B	co_discussed	gene	0.40
MMP2	co_discussed	gene	0.40
PLA2G4A	co_discussed	gene	0.40
STING1	co_discussed	gene	0.40
C3	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DNASE2

Understanding Entity Pages

Summary

Wiki Pages (19)

mitochondrial-dynamics

Neuroinflammation Targeting Therapies

Mitochondrial Dynamics in Neurodegeneration

CGAS Gene

Companies

RAD54 Gene

Age-Sensitive Cortical Vulnerability in Parkinson's Disease

Section 244: Advanced Bioenergetics and ATP Restoration in CBS/PSP

Cytoskeletal Dynamics and Tubulin Targeting in CBS/PSP

Mitochondrial Dynamics Modulators for Parkinson's Disease

STING1 Gene

CD38 Molecule (CD38)

Betz Cells (Primary Motor Cortex)

REL Gene

cGAS Protein

NF-κB p65 Protein

RELA (NF-κB p65)

MMP2 Gene