concept

SYNCRIP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNCRIP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

324Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SYNCRIP
Related Diseases	Hematopoietic Stem Cell Self-renewal

🔮 Predicted Structure: SYNCRIP — AlphaFold A0A7I2V2F0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SYNCRIP["SYNCRIP"]
    SYNCRIP -->|"regulates"| Hematopoietic_Stem_Cell_Self_r["Hematopoietic Stem Cell Self-renewal"]
    SYNCRIP -->|"expressed in"| Hematopoietic_Stem_and_Progeni["Hematopoietic Stem and Progenitor Cells"]
    SYNCRIP -->|"mediates"| Hematopoietic_Stem_Cell_Mainte["Hematopoietic Stem Cell Maintenance"]
    SYNCRIP -->|"activates"| Cancer["Cancer"]
    SYNCRIP -->|"activates"| Aging["Aging"]
    SYNCRIP -->|"activates"| Ms["Ms"]
    h_1e2bd420["h-1e2bd420"] -->|"targets"| SYNCRIP
    SYP["SYP"] -->|"interacts"| SYNCRIP
    FLAVONOIDS["FLAVONOIDS"] -->|"target for"| SYNCRIP
    IGF2BP1["IGF2BP1"] -->|"target for"| SYNCRIP
    EWSR1["EWSR1"] -->|"target for"| SYNCRIP
    YBX1["YBX1"] -->|"target for"| SYNCRIP
    NATURAL_COMPOUNDS["NATURAL COMPOUNDS"] -->|"target for"| SYNCRIP
    MECP2["MECP2"] -->|"target for"| SYNCRIP
    CANCER["CANCER"] -->|"target for"| SYNCRIP
    HSPA1A["HSPA1A"] -->|"target for"| SYNCRIP

Outgoing (200)

Target	Relation	Type	Str
Self-renewal	associated_with	process	0.95
Hematopoietic Stem and Progenitor Cells	regulates	cell_type	0.95
Radial Glial Cell Differentiation	regulates	process	0.95
Neural Progenitor Patterning	involved_in	process	0.95
Larval Brain Development	involved_in	process	0.95
Neural Progenitor Temporal Patterning	involved_in	process	0.95
Proteostasis	associated_with	process	0.95
Hematopoietic Stem Cell Self-renewal	regulates	phenotype	0.92
Hematopoietic Stem and Progenitor Cells	expressed_in	cell_type	0.90
Neuronal Superficial Layer Development	regulates	process	0.90
Radial Glial Cell Fate Progression	mediates	process	0.90
Neurodevelopmental Mrnas	binds	biomarker	0.90
Temporal Neural Fate Specification	regulates	process	0.90
Temporal Regulators	regulates	process	0.90
Hematopoietic Stem Cells	regulates	cell_type	0.90
Hematopoietic Progenitor Cells	regulates	cell_type	0.90
NOTCH	regulates	pathway	0.90
Hematopoietic Stem Cell Maintenance	mediates	phenotype	0.88
Neural Diversity Generation	involved_in	process	0.88
Temporal Transcription Factor Expression	associated_with	process	0.85
Phase Separation	mediates	mechanism	0.85
Neural Fate Specification	involved_in	process	0.85
Neural Fate Specification	contributes_to	process	0.85
hematopoietic stem cells	expressed_in	cell_type	0.85
Self-Renewal	associated_with	biological_process	0.80
Learning and Memory	associated_with	phenotype	0.80
Neural Diversity	contributes_to	phenotype	0.80
neurons	interacts_with	cell_type	0.70
hippocampus	expressed_in	brain_region	0.70
neurons	regulates	cell_type	0.70
neurons	implicated_in	cell_type	0.70
cortex	expressed_in	brain_region	0.70
neurons	transported_by	cell_type	0.70
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Aging	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	stabilizes	disease	0.65
Cancer	stabilizes	disease	0.65
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	activates	disease	0.65
ALS	expressed_in	disease	0.65
ALS	interacts_with	disease	0.65

Incoming (124)

Source	Relation	Type	Str
h-1e2bd420	targets_gene	hypothesis	0.90
IGF2BP1	interacts_with	protein	0.85
h-1e2bd420	targets	hypothesis	0.80
RNA	regulates	gene	0.80
SYP	interacts_with	gene	0.60
CDC42	associated_with	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
EWSR1	therapeutic_target	gene	0.60
YBX1	therapeutic_target	gene	0.60
MECP2	therapeutic_target	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
CDC42	causes	gene	0.60
SYP	associated_with	gene	0.60
IDS	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
APOE	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
APOE	causes	gene	0.60
APP	causes	gene	0.60
IGF2R	causes	gene	0.60
APP	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
APOE	binds_to	gene	0.60
IGF2R	binds_to	gene	0.60
neurogenesis	binds_to	process	0.60
PRDX3	binds_to	gene	0.60
SMARCB1	binds_to	gene	0.60
SORL1	causes	gene	0.60
RHO	associated_with	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
NATURAL COMPOUNDS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
CANCER	stabilizes	gene	0.60
RNA	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
MICROTUBULES	inhibits	gene	0.60
NOTCH	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
GENES	activates	gene	0.60
DENDRITE	transports	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial RNA Granule Rescue Pathway	0.400	neurodegeneration	RNA binding protein dysregulation across

Mentioning Analyses (1)

Scientific analyses that reference this entity

RNA binding protein dysregulation across ALS FTD and AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.490

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial netwo [PMID:39919181]	Lee JY, Huang N, Samuels TJ, Davis I	Sci Adv	2025	1
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoi [PMID:37085479]	Herrejon Chavez F, Luo H, Cifani P, Pine	Nat Commun	2023	1
Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental di [PMID:33874999]	Gillentine MA, Wang T, Hoekzema K, Rosen	Genome Med	2021	1
Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Sta [PMID:41957537]	Feng X, Xiao J, Huang C, Jiang BC, Wang	Adv Sci (Weinh)	2026	0
Qishentaohong granules alleviate heart failure by modulating mitochondrial fissi [PMID:40550296]	["Jin J", "Li Y", "Li S", "Li D", "Liu J	Journal of ethnopharmacology	2025	0
RNA-binding protein SYNCRIP contributes to neuropathic pain through stabilising [PMID:39244479]	Zhang Y, Wang B, Feng X, Wang H, Gao J,	British journal of anaesthesia	2024	0
Raccoon eyes. [PMID:35789012]	Ning J	Journal of paediatrics and chi	2023	0
Perspectives from clinical trials: is geographic atrophy one disease? [PMID:35641821]	["Sivaprasad S", "Chandra S", "Kwon J",	Eye (London, England)	2023	0
Interfacial Imide Polymerization of Functionalized Filled Microcapsule Templates [PMID:36234567]	["Wei Z", "Ma X", "Wang P", "Pan J"]	Nanomaterials (Basel, Switzerl	2022	0
Multiple Primary Malignancies in Head and Neck Cancer: A University Hospital Exp [PMID:34567890]	["Batista MV", "Ulrich J", "Costa L", "R	Cureus	2021	0
Sputtered Porous Li-Fe-P-O Film Cathodes Prepared by Radio Frequency Sputtering [PMID:31371758]	["Sugiawati V", "Vacandio F", "Perrin-Pe	Scientific reports	2019	0
Anaesthesia and analgesia for knee joint arthroplasty. [PMID:33456789]	O'Donnell R, Dolan J	BJA education	2018	0
A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partition [PMID:29483512]	Hobor F, Dallmann A, Ball NJ, Cicchini C	Nature communications	2018	0
Calcium Deregulation: Novel Insights to Understand Friedreich's Ataxia Pathophys [PMID:30333728]	["Abeti R", "Brown A", "Maiolino M", "Pa	Frontiers in cellular neurosci	2018	0
Expression profiling and immunolocalization of Na [PMID:28842746]	["Maduni\u0107 I", "Breljak D", "Karaica	Pflugers Archiv : European jou	2017	0
Glucose toxic effects on granulation tissue productive cells: the diabetics' imp [PMID:23484099]	["Berlanga-Acosta J", "Schultz G", "L\u0	BioMed research international	2013	0

SYNCRIP

Understanding Entity Pages

Wiki Pages (15)

TRA2B Protein - Transformer-2 Beta

mitochondrial-dynamics

CALB1 (Calbindin 1)

Notch2 Protein

syt8

Mitochondrial Dynamics in Neurodegeneration

IDS — Iduronate Sulfatase

SYNE2 Gene

HNRNPU Gene

cct4

HNRNPQ Protein

Photoreceptors in Inherited Retinal Dystrophies

HNRNPQ Gene

EWSR1 Gene