CD40

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD40: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CD40 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, activates. Associated with AD, ALI, Aging. Connected to 74 entities in the SciDEX knowledge graph.

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graph TD
    CD40["<b>CD40</b>"]
    CD40L["CD40L"]
    CD40 -->|"binds"| CD40L
    TRAF2["TRAF2"]
    CD40 -->|"interacts with"| TRAF2
    TRAF3["TRAF3"]
    CD40 -->|"interacts with"| TRAF3
    TRAF5["TRAF5"]
    CD40 -->|"interacts with"| TRAF5
    TRAF6["TRAF6"]
    CD40 -->|"interacts with"| TRAF6
    c_IAP1["c-IAP1"]
    CD40 -->|"interacts with"| c_IAP1
    NF__B(["NF-kappaB"])
    CD40 -->|"activates"| NF__B
    Cancer{"Cancer"}
    CD40 -->|"expressed in"| Cancer
    Autoimmune{"Autoimmune"}
    CD40 -->|"expressed in"| Autoimmune
    Ms{"Ms"}
    CD40 -->|"expressed in"| Ms
    Als{"Als"}
    CD40 -->|"therapeutic target"| Als
    CD40 -->|"therapeutic target"| Autoimmune
    CD40L -->|"binds"| CD40
    AQP4["AQP4"]
    AQP4 -->|"expressed in"| CD40
    CLOCK["CLOCK"]
    CLOCK -->|"regulates"| CD40
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| CD40
    TCR["TCR"]
    TCR -->|"activates"| CD40
    AND["AND"]
    AND -->|"activates"| CD40
    style CD40 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0