concept

LYMPHOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYMPHOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

835Connections

0Hypotheses

0Analyses

46Outgoing

50Incoming

0Experiments

Summary

LYMPHOMA is a concept in neurodegeneration research. Key relationships include: co discussed, interacts with, causes. Associated with LEUKEMIA, TUMOR. Connected to 27 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	LYMPHOMA
Key Genes/Proteins	P53, PI3K, BAX, BCL2, BDNF, LRP1
Related Diseases	FERROPTOSIS
Related Pathways	JAK_STAT_PATHWAY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LYMPHOMA["LYMPHOMA"]
    LYMPHOMA -->|"activates"| Ferroptosis["Ferroptosis"]
    LYMPHOMA -->|"inhibits"| Apoptosis["Apoptosis"]
    LYMPHOMA -->|"activates"| Immune_Response["Immune Response"]
    LYMPHOMA -->|"activates"| Epigenetic["Epigenetic"]
    LYMPHOMA -->|"contributes to"| Sphingolipid["Sphingolipid"]
    LYMPHOMA -->|"target for"| Pi3K["Pi3K"]
    TFR1["TFR1"] -.biomarker for.-> LYMPHOMA
    JUN["JUN"] -->|"inhibits"| LYMPHOMA
    ACSL4["ACSL4"] -->|"regulates"| LYMPHOMA
    GPX4["GPX4"] -->|"regulates"| LYMPHOMA
    DICER1["DICER1"] -->|"regulates"| LYMPHOMA
    RPA1["RPA1"] -->|"inhibits"| LYMPHOMA
    STAT3["STAT3"] -->|"activates"| LYMPHOMA
    AGO2["AGO2"] -->|"inhibits"| LYMPHOMA

Outgoing (201)

Target	Relation	Type	Str
P53	inhibits	gene	0.65
PI3K	activates	gene	0.65
P53	interacts_with	gene	0.65
FERROPTOSIS	treats	phenotype	0.65
T CELL	causes	cell_type	0.60
T CELLS	causes	cell_type	0.60
MTOR	targets	gene	0.60
NRF2	associated_with	gene	0.60
PI3K	interacts_with	gene	0.60
TRAF6	interacts_with	gene	0.60
VEGF	interacts_with	gene	0.60
STAT3	activates	gene	0.60
MACROPHAGE	regulates	cell_type	0.60
MACROPHAGES	regulates	cell_type	0.60
TNF	activates	gene	0.60
AMPK	associated_with	gene	0.50
JNK	associated_with	gene	0.50
HDAC6	associated_with	gene	0.50
HDAC1	associated_with	gene	0.50
HDAC3	associated_with	gene	0.50
SIROLIMUS	associated_with	drug	0.45
RAPAMYCIN	associated_with	drug	0.45
TH	associated_with	gene	0.45
BDNF	associated_with	gene	0.45
STAT3	associated_with	gene	0.45
TNF	associated_with	gene	0.45
MYC	co_discussed	gene	0.40
TUMOR	co_discussed	disease	0.40
STING	co_discussed	gene	0.40
MTOR	co_discussed	gene	0.40
PI3K	co_discussed	gene	0.40
MYD88	co_discussed	gene	0.40
NRF2	co_discussed	gene	0.40
OXIDATIVE STRESS	co_discussed	process	0.40
VEGF	co_discussed	gene	0.40
STAT3	co_discussed	gene	0.40
MACROPHAGES	co_discussed	cell_type	0.40
TNF	co_discussed	gene	0.40
VEGF	activates	gene	0.35
MACROPHAGES	activates	cell_type	0.35
MTOR	inhibits	gene	0.35
MTOR	interacts_with	gene	0.35
MYC	depletes	gene	0.35
RAPAMYCIN	activates	drug	0.35
RAPAMYCIN	inhibits	drug	0.35
RAPAMYCIN	interacts_with	drug	0.35

Incoming (634)

Source	Relation	Type	Str
B CELLS	activates	cell_type	0.80
JAK_STAT_PATHWAY	associated_with	pathway	0.72
B CELL	causes	cell_type	0.65
BAX	degrades	gene	0.65
BCL2	degrades	gene	0.65
BDNF	activates	gene	0.65
LRP1	activates	gene	0.65
B CELL	reduces	cell_type	0.65
B CELLS	interacts_with	cell_type	0.65
B CELLS	regulates	cell_type	0.65
B CELLS	inhibits	cell_type	0.65
CANCER	targets	disease	0.65
CELL DEATH	inhibits	phenotype	0.65
BCR	associated_with	protein	0.64
AKT	targets	gene	0.60
CREB	interacts_with	gene	0.60
ENDOTHELIAL	interacts_with	cell_type	0.60
B CELL	inhibits	cell_type	0.60
B CELLS	depleted_in	cell_type	0.55
BCL2	interacts_with	gene	0.50
BAX	interacts_with	gene	0.50
B CELLS	associated_with	cell_type	0.50
OLAPARIB	associated_with	drug	0.50
SIROLIMUS	associated_with	drug	0.45
RAPAMYCIN	associated_with	drug	0.45
DNA DAMAGE RESPONSE	associated_with	pathway	0.45
B CELL	co_discussed	cell_type	0.40
JAK	co_discussed	gene	0.40
LEUKEMIA	co_discussed	disease	0.40
AKT	co_discussed	gene	0.40
CANCER	co_discussed	disease	0.40
BCL2	co_discussed	gene	0.40
HSP90	co_discussed	gene	0.40
BAX	co_discussed	gene	0.40
FOXO1	co_discussed	gene	0.40
BREAST CANCER	co_discussed	disease	0.40
BDNF	co_discussed	gene	0.40
AUTOPHAGY	co_discussed	process	0.40
CREB	co_discussed	gene	0.40
INFLAMMATION	co_discussed	process	0.40
FOXO1	interacts_with	gene	0.35
ENDOTHELIAL CELLS	activates	cell_type	0.35
FERROPTOSIS	interacts_with	process	0.35
INFLAMMASOME	interacts_with	protein	0.35
CYTOKINES	interacts_with	protein	0.35
CASP3	interacts_with	gene	0.35
BDNF	interacts_with	gene	0.35
CASP3	protects_against	gene	0.35
BCL2	protects_against	gene	0.35
GAPDH	activates	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LYMPHOMA

Understanding Entity Pages

Summary

Wiki Pages (20)

GSK-3β in Neurodegeneration

rankings

DDX3X Gene

RASGRP1 Gene

EPHA7 Gene

Litronesib (LY317615/Enzastaurin)

epigenetics-neurodegeneration

Paraneoplastic Cerebellar Degeneration Neurons

ataxia-telangiectasia

Cerebellar Degeneration Pathway

Kyowa Kirin Co., Ltd.

Cyclophosphamide

MEF2B (Myocyte Enhancer Factor 2B)

CD2AP Gene — CD2-Associated Protein

frontotemporal-lobar-degeneration

Section 187: Advanced Cytokine and Chemokine Network Therapy in CBS/PSP

stiff-person-syndrome

biocon

CASP9 (Caspase 9)