Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AMPA RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are ionotropic glutamate receptors that mediate the majority of fast excitatory synaptic transmission in the brain. Dysfunction contributes to Alzheimer's disease, Parkinson's disease, and ALS.
| Gene Symbol | AMPA RECEPTOR |
| Primary Expression | hippocampus, prefrontal cortex, cortex, cerebral cortex |
| Pathways | glutamate signaling, unfolded protein response, BDNF-TrkB signaling, synaptic plasticity, Mtor |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Interactions | NMDA RECEPTOR, ALZHEIMER, NMDA, EPILEPSY, HDAC3, BIN1 |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["AMPA RECEPTOR"]
N1["ARHGEF7"]
N0 -->|"modulates"| N1
N2["NMDA RECEPTOR"]
N0 -->|"activates"| N2
N3["GLUTAMATE"]
N0 -->|"activates"| N3
N4["Genes"]
N0 -->|"activates"| N4
N5["Glutamate Signaling"]
N0 -->|"activates"| N5
N6["ALZHEIMER"]
N0 -->|"inhibits"| N6
N7["Alzheimer'S Disease"]
N0 -->|"inhibits"| N7
N8["EPIGENETIC"]
N0 -->|"inhibits"| N8
N9["Synaptic Plasticity"]
N0 -->|"inhibits"| N9
N10["disease"]
N0 -->|"inhibits"| N10
N11["ALZHEIMER'S"]
N0 -->|"inhibits"| N11
N12["Long-Term Potentiation"]
N0 -->|"activates"| N12
N0 -->|"interacts with"| N9
N13["APP/PS1"]
N0 -->|"interacts with"| N13
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 protein
class N2 protein
class N5 pathway
class N6 gene
class N7 disease
class N9 pathway
class N10 disease
class N12 pathway| Target | Relation | Type | Str |
|---|---|---|---|
| NMDA RECEPTOR | activates | protein | 0.50 |
| GLUTAMATE | activates | concept | 0.50 |
| Glutamate Signaling | activates | pathway | 0.50 |
| ALZHEIMER | inhibits | gene | 0.50 |
| Alzheimer'S Disease | inhibits | disease | 0.50 |
| Synaptic Plasticity | inhibits | pathway | 0.50 |
| disease | inhibits | disease | 0.50 |
| ALZHEIMER'S | inhibits | concept | 0.50 |
| Long-Term Potentiation | activates | pathway | 0.50 |
| Synaptic Plasticity | interacts_with | pathway | 0.50 |
| APP/PS1 | interacts_with | concept | 0.50 |
| Synaptic Transmission | interacts_with | pathway | 0.50 |
| EAAT4 | associated_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||