protein

BTK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BTK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

129Connections

0Hypotheses

1Analyses

50Outgoing

33Incoming

0Experiments

2Debates

Summary

Page for BTK Protein

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🔬 Protein Info

Gene Symbol	BTK
Subcellular Localization	\| \| TH domain \| Proline-rich \| Proline-rich motifs for SH3 interactions \| \| SH3
Molecular Weight	76 kDa
Amino Acids	659 aa
Pathways	PI3K, NF-κB, MAPK
GeneCards	BTK
Human Protein Atlas	BTK
Associated Diseases	ALS, Alzheimer, neurodegeneration, neuroinflammation
Known Drugs/Compounds	ZANUBRUTINIB
Interactions	AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOPTOSIS
KG Connections	129 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

BTK Inhibitors for Neurodegeneration

therapeutic · 991 words

→

BTK Protein

protein · 584 words

→

Pathway Diagram

graph TD
    BTK(["BTK"])
    mantle_cell_lymphoma["mantle cell lymphoma"]
    NF__B["NF-kappaB"]
    fatty_acid_oxidation["fatty acid oxidation"]
    SHP1["SHP1"]
    Alzheimer["Alzheimer"]
    Cancer["Cancer"]
    Als["Als"]
    Pyroptosis["Pyroptosis"]
    Neuroinflammation["Neuroinflammation"]
    PHAGOCYTOSIS["PHAGOCYTOSIS"]
    ALZHEIMER["ALZHEIMER"]
    APP["APP"]
    AND["AND"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    AMYLOID["AMYLOID"]
    CX3CR1["CX3CR1"]
    MICROGLIA["MICROGLIA"]
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    Er_Stress["Er Stress"]
    BTK -->|"therapeutic_tar"| mantle_cell_lymphoma
    BTK -->|"activates"| NF__B
    BTK -->|"activates"| fatty_acid_oxidation
    SHP1 -.->|"inhibits"| BTK
    BTK -->|"activates"| Alzheimer
    BTK -.->|"inhibits"| Cancer
    BTK -->|"activates"| Als
    BTK -->|"activates"| Cancer
    BTK -.->|"inhibits"| Pyroptosis
    BTK -.->|"inhibits"| Neuroinflammation
    BTK -->|"activates"| PHAGOCYTOSIS
    BTK -->|"activates"| ALZHEIMER
    BTK -->|"activates"| APP
    BTK -->|"activates"| AND
    BTK -->|"activates"| ALZHEIMER_S_DISEASE
    BTK -->|"activates"| AMYLOID
    BTK -->|"activates"| CX3CR1
    BTK -->|"activates"| MICROGLIA
    BTK -->|"activates"| NEURODEGENERATIVE_DISORDERS
    BTK -->|"activates"| Er_Stress
    style BTK fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (96)

Target	Relation	Type	Str
Bcr Signaling	inhibits	pathway	0.95
mantle cell lymphoma	therapeutic_target	disease	0.95
fatty acid oxidation	activates	process	0.90
ALS	implicated_in	disease	0.80
NF-κB	regulates	pathway	0.80
STING	activates	protein	0.80
TBK1	activates	protein	0.80
BCR signaling in AQP4-specific B cells	regulates	pathway	0.70
Alzheimer	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Lymphoma	inhibits	disease	0.65
Pyroptosis	inhibits	disease	0.65
ALS	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
NF-ΚB	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
CANCER	activates	gene	0.60
Aβ	activates	protein	0.60
B Cell	inhibits	cell_type	0.60
Nf-Κb	expressed_in	pathway	0.60
Macrophage	activates	cell_type	0.60
AUTOPHAGY	inhibits	gene	0.60
CD79B	inhibits	gene	0.60
MYD88	inhibits	gene	0.60
Nf-Κb	inhibits	pathway	0.60
Autophagy	inhibits	pathway	0.60
BAX	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
Lipid Metabolism	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
AMYLOID	activates	gene	0.60
CX3CR1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
Er Stress	activates	pathway	0.60
Phagocytosis	activates	pathway	0.60
Amyloid	activates	pathway	0.60
Lipid Metabolism	activates	pathway	0.60
PHAGOCYTOSIS	activates	gene	0.60
APP	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
CXCR4	activates	gene	0.60
NLRP3	activates	gene	0.60
neuroinflammation	associated_with	disease	0.60
ALZHEIMER	activates	gene	0.60
Alzheimer	associated_with	disease	0.60
CXCR4	associated_with	gene	0.60
CXCR4	expressed_in	gene	0.60

Incoming (33)

Source	Relation	Type	Str
SHP1	inhibits	protein	0.88
ZANUBRUTINIB	inhibits	drug	0.80
PHAGOCYTOSIS	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
BDNF	interacts_with	gene	0.60
ALS	regulates	gene	0.60
CX3CR1	activates	gene	0.60
ALS	phosphorylates	gene	0.60
ALS	activates	gene	0.60
AKT	inhibits	gene	0.60
ALS	targets	gene	0.60
ALS	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APP	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
CD79B	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
IL-18	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
RNA	inhibits	gene	0.60
MYD88	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
BCL2	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
BDNF	activates	gene	0.60
ABL1	implicated_in	gene	0.60
APP	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.738

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The title suggests B cells actively maintain tolerance to AQP4, but the specific

closed · Rounds: 4 · Score: 0.66 · 2026-04-13

The title suggests B cells actively maintain tolerance to AQP4, but the specific

closed · Rounds: 4 · Score: 0.79 · 2026-04-13

Related Research

Hypotheses and analyses mentioning BTK in their description or question text

No additional research found