FGF23

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF23: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

FGF23 encodes a hormone-like growth factor that regulates phosphate and vitamin D metabolism, with emerging roles in brain function, cognitive decline, white matter integrity, and potential connections to neurodegenerative disease pathophysiology.

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graph TD
    FGF23["<b>FGF23</b>"]
    Inflammation{"Inflammation"}
    FGF23 -->|"biomarker for"| Inflammation
    Senescence{"Senescence"}
    FGF23 -->|"biomarker for"| Senescence
    Als{"Als"}
    FGF23 -->|"biomarker for"| Als
    Aging{"Aging"}
    FGF23 -->|"biomarker for"| Aging
    Longevity{"Longevity"}
    FGF23 -->|"biomarker for"| Longevity
    Fibrosis{"Fibrosis"}
    FGF23 -->|"biomarker for"| Fibrosis
    ALS{"ALS"}
    FGF23 -->|"biomarker for"| ALS
    Complement(["Complement"])
    FGF23 -->|"biomarker for"| Complement
    Apoptosis(["Apoptosis"])
    FGF23 -->|"biomarker for"| Apoptosis
    APP["APP"]
    FGF23 -->|"biomarker for"| APP
    FGF21["FGF21"]
    FGF23 -->|"activates"| FGF21
    GPNMB["GPNMB"]
    FGF23 -->|"biomarker for"| GPNMB
    FGF21 -->|"activates"| FGF23
    APP -->|"biomarker for"| FGF23
    FNDC5["FNDC5"]
    FNDC5 -->|"activates"| FGF23
    S100B["S100B"]
    S100B -->|"biomarker for"| FGF23
    PLAU["PLAU"]
    PLAU -->|"activates"| FGF23
    CXCL10["CXCL10"]
    CXCL10 -->|"activates"| FGF23
    C1Q["C1Q"]
    C1Q -->|"biomarker for"| FGF23
    CX3CL1["CX3CL1"]
    CX3CL1 -->|"activates"| FGF23
    VIM["VIM"]
    VIM -->|"activates"| FGF23
    BDNF["BDNF"]
    BDNF -->|"activates"| FGF23
    TGM2["TGM2"]
    TGM2 -->|"biomarker for"| FGF23
    GPNMB -->|"biomarker for"| FGF23
    style FGF23 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0