concept

PGRN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGRN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

211Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PGRN
Key Genes/Proteins	TAR
Related Diseases	Frailty, Alzheimer's disease, Parkinson's disease, limbic-predominant age-related transactivation response DNA-binding protein 43 encephalopathy, amyotrophic lateral sclerosis
Related Pathways	oxidative stress response

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PGRN["PGRN"]
    style PGRN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PGRN -.->|"biomarker for"| Fibrosis["Fibrosis"]
    PGRN -.->|"biomarker for"| ALS["ALS"]
    PGRN -.->|"biomarker for"| Aging["Aging"]
    PGRN -.->|"biomarker for"| Inflammation["Inflammation"]
    PGRN -.->|"biomarker for"| Senescence["Senescence"]
    PGRN -.->|"biomarker for"| Als["Als"]
    PGRN -->|"causes"| Dementia["Dementia"]
    PGRN -->|"causes"| Neurodegeneration["Neurodegeneration"]
    PGRN -->|"expressed in"| Alzheimer["Alzheimer"]
    IGF_1([IGF-1]) -.->|"biomarker for"| PGRN
    MITOCHONDRIA([MITOCHONDRIA]) -.->|"biomarker for"| PGRN
    FGF21([FGF21]) -->|"activates"| PGRN
    GPNMB([GPNMB]) -.->|"biomarker for"| PGRN
    VIMENTIN([VIMENTIN]) -->|"activates"| PGRN
    AMYLOID([AMYLOID]) -.->|"biomarker for"| PGRN
    VIM([VIM]) -->|"activates"| PGRN
    HMGB1([HMGB1]) -.->|"biomarker for"| PGRN
    S100B([S100B]) -.->|"biomarker for"| PGRN
    C1Q([C1Q]) -.->|"biomarker for"| PGRN

Outgoing (133)

Target	Relation	Type	Str
Frailty	biomarker_for	phenotype	0.95
neurons	regulates	cell_type	0.80
microglia	regulates	cell_type	0.80
Alzheimer's disease	associated_with	disease	0.80
Parkinson's disease	associated_with	disease	0.80
limbic-predominant age-related transactivation response DNA-binding protein 43 encephalopathy	associated_with	disease	0.80
amyotrophic lateral sclerosis	exacerbates	disease	0.80
frontotemporal dementia	exacerbates	disease	0.80
frontotemporal dementia	causes	disease	0.70
neurons	expressed_in	cell_type	0.70
stem cells	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
neurodegeneration	implicated_in	disease	0.70
neurodegeneration	protects_against	disease	0.70
TAR	interacts_with	gene	0.70
neurodegeneration	regulates	disease	0.70
Fibrosis	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Als	causes	disease	0.65
Dementia	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
ALS	causes	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
microglia	expressed_in	cell_type	0.60
AND	activates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
PROGRANULIN	activates	gene	0.60
PLAU	activates	gene	0.60
CX3CL1	activates	gene	0.60
GHRL	biomarker_for	gene	0.60
TGM2	biomarker_for	gene	0.60
Apoptosis	biomarker_for	pathway	0.60
Amyloid	biomarker_for	pathway	0.60
Complement	biomarker_for	pathway	0.60
IL-6	activates	gene	0.60
S100B	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
FNDC5	activates	gene	0.60
BDNF	activates	gene	0.60
IGF-1	biomarker_for	gene	0.60

Incoming (78)

Source	Relation	Type	Str
IGF-1	biomarker_for	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
FGF21	activates	gene	0.60
GPNMB	biomarker_for	gene	0.60
VIMENTIN	activates	gene	0.60
AMYLOID	biomarker_for	gene	0.60
VIM	activates	gene	0.60
HMGB1	biomarker_for	gene	0.60
S100B	biomarker_for	gene	0.60
C1Q	biomarker_for	gene	0.60
FNDC5	activates	gene	0.60
FGF23	activates	gene	0.60
IL-6	activates	gene	0.60
CXCL10	activates	gene	0.60
AGING	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
APP	biomarker_for	gene	0.60
BDNF	activates	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
CX3CL1	activates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
GHRL	biomarker_for	gene	0.60
LYSOSOME	causes	gene	0.60
GAIN	causes	gene	0.60
DEMENTIA	causes	gene	0.60
FTLD	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
ALS	expressed_in	gene	0.60
TDP-43	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
NEURODEGENERATION	causes	gene	0.60
GRN	causes	gene	0.60
PROGRANULIN	causes	gene	0.60
FUS	interacts_with	gene	0.60
GRN	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
PROGRANULIN	associated_with	gene	0.60
MOTOR NEURONS	interacts_with	gene	0.60
NESTIN	expressed_in	gene	0.60
BRAIN INJURY	associated_with	gene	0.60
PROGRANULIN	activates	gene	0.60
TGM2	biomarker_for	gene	0.60
AND	activates	gene	0.60
GENES	biomarker_for	gene	0.60
PLAU	activates	gene	0.60
GRN	inhibits	gene	0.60
GRN	activates	gene	0.60
KL	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PGRN

Understanding Entity Pages

Wiki Pages (20)

Frontotemporal Dementia (FTD)

GRN Progranulin FTD Causal Chain

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TDP-43 Pathology in Corticobasal Syndrome

Progranulin Therapy for Neurodegeneration

TDP-43 Co-pathology in Corticobasal Syndrome

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Denali Therapeutics

Progranulin (PGRN) - Biomarker

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