concept

GBP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GBP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

40Outgoing

23Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GBP2
Key Genes/Proteins	NEUROINFLAMMATION, GLIOBLASTOMA, PI3K
Related Diseases	Glioblastoma Invasion, Neuroinflammation, Ischemia, Inflammation, Stroke
Related Pathways	Nf-Κb, Immune Response

Wiki Pages (2)

Knowledge base pages for this entity

Radial Glia

cell · 1199 words

→

Neurotoxic (A1) Reactive Astrocytes

cell · 750 words

→

Pathway Diagram

graph TD
    GBP2["GBP2"]
    GBP2 -->|"modulates"| Glioblastoma_Invasion["Glioblastoma Invasion"]
    GBP2 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    GBP2 -->|"activates"| Ischemia["Ischemia"]
    GBP2 -->|"activates"| Inflammation["Inflammation"]
    GBP2 -->|"activates"| Stroke["Stroke"]
    GBP2 -->|"regulates"| Tumor["Tumor"]
    GBP2 -->|"activates"| ALS["ALS"]
    GBP2 -->|"activates"| Glioblastoma["Glioblastoma"]
    SPHK1["SPHK1"] -->|"expressed in"| GBP2
    ASTROCYTES["ASTROCYTES"] -->|"activates"| GBP2
    ASTROCYTE["ASTROCYTE"] -->|"activates"| GBP2
    STROKE["STROKE"] -->|"activates"| GBP2
    AND["AND"] -->|"expressed in"| GBP2
    NRF2["NRF2"] -->|"expressed in"| GBP2
    GSS["GSS"] -->|"expressed in"| GBP2
    BDNF["BDNF"] -->|"expressed in"| GBP2

Outgoing (40)

Target	Relation	Type	Str
Glioblastoma Invasion	modulates	phenotype	0.80
Neuroinflammation	activates	disease	0.65
Ischemia	activates	disease	0.65
Inflammation	activates	disease	0.65
Stroke	activates	disease	0.65
Tumor	regulates	disease	0.65
ALS	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
NEUROINFLAMMATION	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
GLIOBLASTOMA	activates	gene	0.60
PI3K	activates	gene	0.60
Immune Response	activates	pathway	0.60
Mtor	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Angiogenesis	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
ANXA2	regulates	gene	0.60
GLUT3	regulates	gene	0.60
FN1	regulates	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Stem Cell	therapeutic_target	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
GBM	regulates	gene	0.60
Radial Glia	therapeutic_target	cell_type	0.60
PHIP	regulates	gene	0.60
Akt	therapeutic_target	protein	0.60
Pi3K	therapeutic_target	protein	0.60
glioblastoma	regulates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60
Neural Stem Cell	expressed_in	cell_type	0.55
Stem Cell	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55

Incoming (23)

Source	Relation	Type	Str
SPHK1	expressed_in	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
STROKE	activates	gene	0.60
AND	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
GSS	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
GFAP	expressed_in	gene	0.60
NF-ΚB	activates	gene	0.60
TLR4	activates	gene	0.60
GENES	regulates	gene	0.60
GBM	regulates	gene	0.60
AKT	activates	gene	0.60
PHIP	regulates	gene	0.60
ANXA2	regulates	gene	0.60
AND	regulates	gene	0.60
MTOR	activates	gene	0.60
GLUT3	regulates	gene	0.60
FN1	regulates	gene	0.60
PI3K	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found