concept

CIRRHOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CIRRHOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

473Connections
0Hypotheses
0Analyses
15Outgoing
4Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameCIRRHOSIS
Key Genes/ProteinsCCL2
Related DiseasesHEPATOCELLULAR CARCINOMA, NASH, HCV, NAFLD, HYPERTENSION

Wiki Pages (20)

Knowledge base pages for this entity

nf1-protein

protein · 4422 words

Liver-Brain Neurodegeneration Axis

mechanism · 3264 words

Manganese-Related Neurodegeneration (Manganism)

disease · 2953 words

NNMT Gene

gene · 2736 words

atp5b

gene · 2688 words

Pathway Diagram

graph TD
    CIRRHOSIS["CIRRHOSIS"]
    CIRRHOSIS -->|"causes"| fibrosis["fibrosis"]
    CIRRHOSIS -->|"activates"| Pi3K["Pi3K"]
    CIRRHOSIS -->|"activates"| Akt["Akt"]
    CIRRHOSIS -->|"activates"| Mtor["Mtor"]
    CIRRHOSIS -->|"target for"| Autophagy["Autophagy"]
    CIRRHOSIS -->|"target for"| Mapk["Mapk"]
    CIRRHOSIS -->|"inhibits"| Mitophagy["Mitophagy"]
    CIRRHOSIS -->|"target for"| Immune_Response["Immune Response"]
    CIRRHOSIS -->|"activates"| Er_Stress["Er Stress"]
    gut_microbiome_modulation["gut microbiome modulation"] -->|"treats"| CIRRHOSIS
    OCLN["OCLN"] -->|"expressed in"| CIRRHOSIS
    EGF["EGF"] -->|"activates"| CIRRHOSIS
    CYP3A4["CYP3A4"] -->|"activates"| CIRRHOSIS
    PDK1["PDK1"] -->|"activates"| CIRRHOSIS
    MTOR["MTOR"] -->|"activates"| CIRRHOSIS
    EGFR["EGFR"] -->|"activates"| CIRRHOSIS
    ERCC3["ERCC3"] -->|"activates"| CIRRHOSIS
    CEBPB["CEBPB"] -->|"activates"| CIRRHOSIS
    CYP1A2["CYP1A2"] -->|"activates"| CIRRHOSIS

Outgoing (204)

TargetRelationTypeStr
HEPATOCELLULAR CARCINOMAincreases_riskdisease0.65
NAFLDassociated_withdisease0.50
CCL2associated_withgene0.45
HEPATOCELLULAR CARCINOMAbiomarker_fordisease0.35
MACROPHAGEScausescell_type0.35

Incoming (269)

SourceRelationTypeStr
NASHinteracts_withdisease0.65
HCVcausesdisease0.64
NAFLDactivatesdisease0.56
CANCERregulatesdisease0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found