Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CIRRHOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CIRRHOSIS |
| Key Genes/Proteins | CCL2 |
| Related Diseases | HEPATOCELLULAR CARCINOMA, NASH, HCV, NAFLD, HYPERTENSION |
Knowledge base pages for this entity
graph TD
CIRRHOSIS["CIRRHOSIS"]
CIRRHOSIS -->|"causes"| fibrosis["fibrosis"]
CIRRHOSIS -->|"activates"| Pi3K["Pi3K"]
CIRRHOSIS -->|"activates"| Akt["Akt"]
CIRRHOSIS -->|"activates"| Mtor["Mtor"]
CIRRHOSIS -->|"target for"| Autophagy["Autophagy"]
CIRRHOSIS -->|"target for"| Mapk["Mapk"]
CIRRHOSIS -->|"inhibits"| Mitophagy["Mitophagy"]
CIRRHOSIS -->|"target for"| Immune_Response["Immune Response"]
CIRRHOSIS -->|"activates"| Er_Stress["Er Stress"]
gut_microbiome_modulation["gut microbiome modulation"] -->|"treats"| CIRRHOSIS
OCLN["OCLN"] -->|"expressed in"| CIRRHOSIS
EGF["EGF"] -->|"activates"| CIRRHOSIS
CYP3A4["CYP3A4"] -->|"activates"| CIRRHOSIS
PDK1["PDK1"] -->|"activates"| CIRRHOSIS
MTOR["MTOR"] -->|"activates"| CIRRHOSIS
EGFR["EGFR"] -->|"activates"| CIRRHOSIS
ERCC3["ERCC3"] -->|"activates"| CIRRHOSIS
CEBPB["CEBPB"] -->|"activates"| CIRRHOSIS
CYP1A2["CYP1A2"] -->|"activates"| CIRRHOSIS| Target | Relation | Type | Str |
|---|---|---|---|
| HEPATOCELLULAR CARCINOMA | increases_risk | disease | 0.65 |
| NAFLD | associated_with | disease | 0.50 |
| CCL2 | associated_with | gene | 0.45 |
| HEPATOCELLULAR CARCINOMA | biomarker_for | disease | 0.35 |
| MACROPHAGES | causes | cell_type | 0.35 |
| NAFLD | causes | disease | 0.35 |
| NAFLD | inhibits | disease | 0.35 |
| HEPATOCELLULAR CARCINOMA | inhibits | disease | 0.35 |
| HEPATOCELLULAR CARCINOMA | therapeutic_target | disease | 0.35 |
| HEPATOCELLULAR CARCINOMA | interacts_with | disease | 0.35 |
| HYPERTENSION | interacts_with | disease | 0.35 |
| INFLAMMATION | interacts_with | process | 0.35 |
| NAFLD | interacts_with | disease | 0.35 |
| FIBROBLASTS | regulates | cell_type | 0.35 |
| STEM CELLS | regulates | cell_type | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||