Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MIR454: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MIR454 |
| Key Genes/Proteins | FAM83A, TSPAN1, MAP1LC3, ATG, AMPK, MTOR |
| Related Diseases | Tumor, Cancer, ALS, Carcinoma, Als |
| Related Pathways | Autophagy, Wnt, Mtor |
graph TD
MIR454["MIR454"]
MIR454 -->|"regulates"| FAM83A["FAM83A"]
MIR454 -->|"regulates"| TSPAN1["TSPAN1"]
MIR454 -->|"activates"| Tumor["Tumor"]
MIR454 -->|"activates"| Cancer["Cancer"]
MIR454 -->|"activates"| ALS["ALS"]
MIR454 -->|"activates"| Als["Als"]
MIR454 -->|"activates"| Autophagy["Autophagy"]
MIR454 -->|"activates"| Wnt["Wnt"]
WNT["WNT"] -->|"activates"| MIR454
CTNNB1["CTNNB1"] -->|"activates"| MIR454
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| MIR454
FAM83A -->|"activates"| MIR454
AND["AND"] -->|"activates"| MIR454
P62["P62"] -->|"activates"| MIR454
CANCER["CANCER"] -->|"activates"| MIR454
TSPAN1 -->|"activates"| MIR454| Target | Relation | Type | Str |
|---|---|---|---|
| FAM83A | regulates | gene | 0.85 |
| TSPAN1 | regulates | gene | 0.85 |
| Tumor | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Als | activates | disease | 0.65 |
| MAP1LC3 | associated_with | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| ATG | associated_with | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| GAPDH | associated_with | gene | 0.60 |
| CCND1 | associated_with | gene | 0.60 |
| AXIN2 | associated_with | gene | 0.60 |
| FAM83A | activates | gene | 0.60 |
| RAB7A | associated_with | gene | 0.60 |
| GFP | associated_with | gene | 0.60 |
| MYC | associated_with | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| TCF4 | associated_with | gene | 0.60 |
| GSK3B | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| RAS | associated_with | gene | 0.60 |
| AXIN | associated_with | gene | 0.60 |
| TSPAN1 | activates | gene | 0.60 |
| LAMP1 | associated_with | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| Raf | activates | protein | 0.60 |
| Actin | associated_with | protein | 0.60 |
| WNT | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| TSPAN1 | targets | gene | 0.60 |
| TSPAN1 | associated_with | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| RAB7A | activates | gene | 0.60 |
| RAS | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| TCF4 | activates | gene | 0.60 |
| Wnt signaling | participates_in | pathway | 0.60 |
| cancer | activates | disease | 0.60 |
| cancer | associated_with | disease | 0.60 |
| MKI67 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LAMP1 | associated_with | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| RAB7A | associated_with | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| RAS | associated_with | gene | 0.60 |
| GSK3B | associated_with | gene | 0.60 |
| APC | associated_with | gene | 0.60 |
| CSNK1A1 | associated_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| GFP | associated_with | gene | 0.60 |
| GAPDH | associated_with | gene | 0.60 |
| AXIN2 | associated_with | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| CYCLIN D1 | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| CTNNB1 | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| FAM83A | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| CCND1 | associated_with | gene | 0.60 |
| MYC | associated_with | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| TCF4 | associated_with | gene | 0.60 |
| TSPAN1 | activates | gene | 0.60 |
| AXIN | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| FAM83A | targets | gene | 0.60 |
| FAM83A | associated_with | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| APC | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| AXIN2 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| CCND1 | activates | gene | 0.60 |
| CSNK1A1 | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| GFP | activates | gene | 0.60 |
| GSK3B | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||