gene

TCF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TCF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

159Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Transcription factor 4 (TCF4), a basic helix-loop-helix transcription factor linked to neurodevelopmental disorders and neurodegeneration

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🧬 Gene Info

Gene Symbol	TCF4
Full Name	Transcription Factor 4
Chromosome	18q21.2
Protein Type	Transcription Factor
Function	TCF4 is a basic helix-loop-helix (bHLH) transcription factor that plays critical roles in neurodevelopment, synaptic plasticity, and neuronal differentiation.
Primary Expression	neuronal progenitor cells and post-mitotic neurons
Molecular Weight	67 kDa
Amino Acids	010 aa
Exons	20
Pathways	Microrna, Wnt, Wnt signaling, autophagy pathway
UniProt ID	Q9UJL9
NCBI Gene ID	6981
Ensembl ID	ENSG00000196628
OMIM	604275
GeneCards	TCF4
Human Protein Atlas	TCF4
Associated Diseases	Cancer, Carcinoma, Fuchs Endothelial Corneal Dystrophy, Pitt-Hopkins Syndrome, psychiatric disorders, schizophrenia
Known Drugs/Compounds	rapamycin
Interactions	MYC, FOXP3, MMP9, LAMP1, RAB7A, TCF7L2
KG Connections	159 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TCF4 — AlphaFold Q9UJL9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TCF4["TCF4"]
    TCF4 -->|"activates"| Tumor["Tumor"]
    TCF4 -->|"activates"| Als["Als"]
    TCF4 -->|"activates"| Cancer["Cancer"]
    TCF4 -->|"activates"| ALS["ALS"]
    TCF4 -->|"activates"| MYC["MYC"]
    TCF4 -->|"activates"| FOXP3["FOXP3"]
    TCF4 -->|"activates"| CANCER["CANCER"]
    TCF4 -->|"activates"| Wnt["Wnt"]
    P62["P62"] -->|"activates"| TCF4
    MMP9["MMP9"] -->|"activates"| TCF4

Outgoing (84)

Target	Relation	Type	Str
Fuchs Endothelial Corneal Dystrophy	associated_with	disease	0.90
Pitt-Hopkins Syndrome	causes	disease	0.80
seizures	causes	phenotype	0.80
Huntington's disease	dysregulated_in	disease	0.80
psychiatric disorders	associated_with	disease	0.70
schizophrenia	associated_with	disease	0.70
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Huntington	expressed_in	disease	0.65
Huntington	encodes	disease	0.65
MYC	associated_with	gene	0.60
LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
CTNNB1	associated_with	gene	0.60
AXIN2	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
APC	associated_with	gene	0.60
MYC	activates	gene	0.60
FOXP3	activates	gene	0.60
MMP9	activates	gene	0.60
DRD2	expressed_in	gene	0.60
DRD1	expressed_in	gene	0.60
TCF7L2	inhibits	gene	0.60
Mtor	associated_with	pathway	0.60
Wnt	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
CANCER	activates	gene	0.60
Wnt	activates	pathway	0.60
CYCLIN D1	associated_with	gene	0.60
RAS	associated_with	gene	0.60
AXIN	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
ATG	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GFP	associated_with	gene	0.60
CSNK1A1	associated_with	gene	0.60
GENES	activates	gene	0.60

Incoming (75)

Source	Relation	Type	Str
SQSTM1	associated_with	gene	0.60
AXIN2	associated_with	gene	0.60
P62	activates	gene	0.60
MTOR	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
APC	associated_with	gene	0.60
CTNNB1	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
MYC	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
MMP9	activates	gene	0.60
LC3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
MYC	activates	gene	0.60
VIMENTIN	activates	gene	0.60
APC	activates	entity	0.60
AXIN2	activates	entity	0.60
BECN1	activates	entity	0.60
CTNNB1	activates	entity	0.60
GAPDH	activates	entity	0.60
GSK3B	activates	entity	0.60
LAMP1	activates	entity	0.60
LC3	activates	entity	0.60
MTOR	activates	entity	0.60
RAB7A	activates	entity	0.60
SQSTM1	activates	entity	0.60
DRD1	expressed_in	gene	0.60
DRD1	encodes	gene	0.60
DRD2	encodes	gene	0.60
MKI67	activates	gene	0.60
LDH	activates	gene	0.60
LEF1	activates	gene	0.60
OLIG2	causes	gene	0.60
SOX10	causes	gene	0.60
MAP1LC3	associated_with	gene	0.60
ATG	associated_with	gene	0.60
CSNK1A1	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GFP	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
RAS	associated_with	gene	0.60
AND	activates	gene	0.60
C-MYC	activates	gene	0.60
WNT	activates	gene	0.60
AMPK	activates	entity	0.60
CANCER	activates	entity	0.60
WNT	associated_with	gene	0.60
RNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TCF4

Understanding Entity Pages

Summary

Wiki Pages (21)

TCF4 Gene

Cerebellar Purkinje Cells in Autism Spectrum Disorder

KDM4B (Lysine Demethylase 4B)

ngn1

NGN2 (Neurogenin-2)

rest-protein

ASCL1 Gene

CTNNBIP1 Gene — Catenin Beta Interacting Protein 1 (ICAT)

NEUROD2 Gene

TCF3

NEUROG1 (Neurogenin-1)

AtlasX Bio

TCF7L2 (Transcription Factor 7-Like 2)

Huntington's Disease Genetic Variants

CREB1 Protein

TCF4 Protein