Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MTHFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Hyper-Homocysteinemia | associated_with | phenotype | 0.85 |
| levodopa adverse drug reactions | associated_with | phenotype | 0.75 |
| SOD1 | interacts_with | gene | 0.60 |
| NBEA | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| SLC30A8 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| Alzheimer's disease | associated_with | disease | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| benchmark_ot_ad_answer_key:MTHFR | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APLP1 | interacts_with | gene | 0.60 |
| APOE | interacts_with | gene | 0.60 |
| CLDN5 | interacts_with | gene | 0.60 |
| MMP9 | interacts_with | gene | 0.60 |
| resveratrol | targets | drug | 0.60 |
| curcumin | targets | drug | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| ABCG2 | associated_with | gene | 0.60 |
| ADRA2A | associated_with | gene | 0.60 |
| ADRB2 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| BCHE | associated_with | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| CYP2C19 | associated_with | gene | 0.60 |
| CYP2D6 | associated_with | gene | 0.60 |
| CYP3A4 | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| GSTP1 | associated_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| MAOB | associated_with | gene | 0.60 |
| DRD2 | interacts_with | gene | 0.60 |
| HOMER1 | interacts_with | gene | 0.60 |
| levodopa | targets | drug | 0.60 |
| ACE | activates | gene | 0.60 |
| ACE | associated_with | gene | 0.60 |
| CYP1A2 | associated_with | gene | 0.60 |
| CYP2E1 | associated_with | gene | 0.60 |
| CYP3A5 | associated_with | gene | 0.60 |
| LDL | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:MTHFR | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||