gene

GSTP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSTP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

144Connections

0Hypotheses

0Analyses

50Outgoing

49Incoming

Summary

Gene page for GSTP1 — Glutathione S-Transferase Pi 1

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🧬 Gene Info

Gene Symbol	GSTP1
Full Name	Glutathione S-Transferase Pi 1
Chromosome	11q13.2
Protein Family	Pi class glutathione S-transferase family
Protein Type	Enzyme
Subcellular Localization	Cytoplasm, nucleus
Molecular Weight	23 kDa
Amino Acids	198 aa
Pathways	Signaling:** Interacts with TNF receptor, MAPK, NF-κB
UniProt ID	GSTP1
Ensembl ID	ENSG00000042832
GeneCards	GSTP1
Human Protein Atlas	GSTP1
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease, Anxiety, Dementia
Known Drugs/Compounds	Galangin
Interactions	GAL, PTGS2, JUN, SLC7A11, NRF2, GPX4
KG Connections	144 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GSTP1["GSTP1"]
    GSTP1 -->|"target for"| Dementia["Dementia"]
    GSTP1 -->|"inhibits"| Fibrosis["Fibrosis"]
    GSTP1 -->|"inhibits"| Cardiac["Cardiac"]
    GSTP1 -->|"inhibits"| Ms["Ms"]
    GSTP1 -->|"inhibits"| Cancer["Cancer"]
    GSTP1 -->|"target for"| Epigenetic["Epigenetic"]
    GSTP1 -->|"target for"| GENES["GENES"]
    GSTP1 -->|"target for"| SREBF1["SREBF1"]
    GSTP1 -->|"target for"| TNF["TNF"]
    NFE2L2["NFE2L2"] -->|"target for"| GSTP1
    TGFB1["TGFB1"] -->|"target for"| GSTP1
    PPARA["PPARA"] -->|"target for"| GSTP1
    PER["PER"] -->|"interacts"| GSTP1

Outgoing (95)

Target	Relation	Type	Str
JNK	modulates	protein	0.80
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Fibrosis	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Dementia	interacts_with	disease	0.65
Inflammation	regulates	disease	0.65
Ferroptosis	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
CYP3A4	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
SREBF1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
CAT	therapeutic_target	gene	0.60
IL4	therapeutic_target	gene	0.60
PTEN	therapeutic_target	gene	0.60
PRKCA	therapeutic_target	gene	0.60
GAL	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
JUN	activates	gene	0.60
SLC7A11	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
BCHE	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
JNK	inhibits	gene	0.60
TGM2	activates	gene	0.60
Ferroptosis Pathway	activates	pathway	0.60

Incoming (49)

Source	Relation	Type	Str
Galangin	activates	drug	0.85
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
TGFB1	therapeutic_target	gene	0.60
PPARA	therapeutic_target	gene	0.60
ABCG2	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SLC7A11	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
JNK	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
JUN	activates	gene	0.60
NRF2	inhibits	gene	0.60
TGM2	activates	gene	0.60
GAL	inhibits	gene	0.60
CYP2C19	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
PER	interacts_with	gene	0.60
ANXIETY	associated_with	gene	0.60
CYP2E1	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
CYP1A2	associated_with	gene	0.60
C-JUN	activates	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
AND	inhibits	gene	0.60
AND	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
FERROPTOSIS	activates	gene	0.60
DNA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GSTP1

Understanding Entity Pages

Summary

Wiki Pages (14)

GSTP1 — Glutathione S-Transferase Pi 1

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

Alzheimer's Disease

PRKCA — Protein Kinase C Alpha

NRF2 Signaling Pathway in Neurodegeneration

NRF2 Gene

NBEA — Neurobeachin

TIGAR Protein — TP53-Induced Glycolysis and Apoptosis Regulator

slc30a8

GSTT1 (Glutathione S-Transferase Theta 1)

GSTP1 Protein (Glutathione S-Transferase Pi 1)