Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC30A8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SLC30A8 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, therapeutic target. Associated with Als, Alzheimer, Anxiety. Connected to 66 entities in the SciDEX knowledge graph.
| Gene Symbol | SLC30A8 |
| Protein Type | Transporter |
| Function | SLC30A8 encodes ZnT-8 (Zinc Transporter 8), a member of the SLC30 family of zinc transporters that facilitate zinc efflux from cells [@chimienti2004]. |
| Subcellular Localization | **Insulin Granules**: Primary localization in pancreatic beta cells |
| Pathways | Epigenetic, autophagy pathway |
| Ensembl ID | ENSG00000137336 |
| GeneCards | SLC30A8 |
| Human Protein Atlas | SLC30A8 |
| Associated Diseases | Als, Alzheimer, Alzheimer'S Disease, Anxiety, Dementia |
| Interactions | PER, GENES |
| KG Connections | 82 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SLC30A8["<b>SLC30A8</b>"]
Alzheimer{"Alzheimer"}
SLC30A8 -->|"associated with"| Alzheimer
Dementia{"Dementia"}
SLC30A8 -->|"therapeutic target"| Dementia
Depression{"Depression"}
SLC30A8 -->|"associated with"| Depression
Anxiety{"Anxiety"}
SLC30A8 -->|"associated with"| Anxiety
SLC30A8 -->|"associated with"| Dementia
SLC30A8 -->|"interacts with"| Dementia
COMT["COMT"]
SLC30A8 -->|"associated with"| COMT
NBEA["NBEA"]
SLC30A8 -->|"associated with"| NBEA
HTR2C["HTR2C"]
SLC30A8 -->|"associated with"| HTR2C
ADRA2A["ADRA2A"]
SLC30A8 -->|"associated with"| ADRA2A
BCHE["BCHE"]
SLC30A8 -->|"associated with"| BCHE
SLC6A2["SLC6A2"]
SLC30A8 -->|"associated with"| SLC6A2
MAOB["MAOB"]
MAOB -->|"associated with"| SLC30A8
GABRA1["GABRA1"]
GABRA1 -->|"associated with"| SLC30A8
CHAT["CHAT"]
CHAT -->|"associated with"| SLC30A8
CYP2D6["CYP2D6"]
CYP2D6 -->|"associated with"| SLC30A8
APOE["APOE"]
APOE -->|"associated with"| SLC30A8
HMGCR["HMGCR"]
HMGCR -->|"associated with"| SLC30A8
OPRM1["OPRM1"]
OPRM1 -->|"associated with"| SLC30A8
BCHE -->|"associated with"| SLC30A8
ADRA2A -->|"associated with"| SLC30A8
ADRB2["ADRB2"]
ADRB2 -->|"associated with"| SLC30A8
GSTP1["GSTP1"]
GSTP1 -->|"associated with"| SLC30A8
ABCB1["ABCB1"]
ABCB1 -->|"associated with"| SLC30A8
style SLC30A8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Anxiety | associated_with | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Type 2 Diabetes | associated_with | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| COMT | associated_with | gene | 0.60 |
| NBEA | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| ADRA2A | associated_with | gene | 0.60 |
| BCHE | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| GSTP1 | associated_with | gene | 0.60 |
| CYP3A4 | associated_with | gene | 0.60 |
| ABCG2 | associated_with | gene | 0.60 |
| ADRB2 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| CYP2D6 | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| MAOB | associated_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| MTNR1B | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| Epigenetic | associated_with | pathway | 0.60 |
| PER | interacts_with | gene | 0.60 |
| CYP2E1 | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| CYP1A2 | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ANXIETY | associated_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| Epigenetic | interacts_with | pathway | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| CYP3A5 | associated_with | gene | 0.60 |
| Alzheimer's disease | associated_with | disease | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| Alzheimer'S Disease | associated_with | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| ALZHEIMER'S | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ADRA2A | associated_with | gene | 0.70 |
| MAOB | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| CYP2D6 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| BCHE | associated_with | gene | 0.60 |
| ADRB2 | associated_with | gene | 0.60 |
| GSTP1 | associated_with | gene | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| ABCG2 | associated_with | gene | 0.60 |
| CYP3A4 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| TCF7L2 | associated_with | gene | 0.60 |
| HTR2C | associated_with | entity | 0.60 |
| NBEA | associated_with | entity | 0.60 |
| CYP2C19 | associated_with | gene | 0.60 |
| MTHFR | associated_with | gene | 0.60 |
| CYP1A2 | associated_with | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| ANXIETY | associated_with | gene | 0.60 |
| CYP2E1 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| PER | interacts_with | gene | 0.60 |
| CYP3A5 | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| PER | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||