gene

SLC30A8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC30A8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections
0Hypotheses
0Analyses
49Outgoing
33Incoming
0Experiments

Summary

SLC30A8 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, therapeutic target. Associated with Als, Alzheimer, Anxiety. Connected to 66 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSLC30A8
Protein TypeTransporter
FunctionSLC30A8 encodes ZnT-8 (Zinc Transporter 8), a member of the SLC30 family of zinc transporters that facilitate zinc efflux from cells [@chimienti2004].
Subcellular Localization**Insulin Granules**: Primary localization in pancreatic beta cells
PathwaysEpigenetic, autophagy pathway
Ensembl IDENSG00000137336
GeneCardsSLC30A8
Human Protein AtlasSLC30A8
Associated DiseasesAls, Alzheimer, Alzheimer'S Disease, Anxiety, Dementia
InteractionsPER, GENES
KG Connections82 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

slc30a8

gene · 919 words

OPRM1 — Mu-Opioid Receptor

gene · 1470 words

Mu-Opioid Receptor Protein

protein · 1301 words

NBEA — Neurobeachin

gene · 1243 words

ADRA2A Gene

gene · 645 words

Genes

index · 271 words

Pathway Diagram

graph TD
    SLC30A8["<b>SLC30A8</b>"]
    Alzheimer{"Alzheimer"}
    SLC30A8 -->|"associated with"| Alzheimer
    Dementia{"Dementia"}
    SLC30A8 -->|"therapeutic target"| Dementia
    Depression{"Depression"}
    SLC30A8 -->|"associated with"| Depression
    Anxiety{"Anxiety"}
    SLC30A8 -->|"associated with"| Anxiety
    SLC30A8 -->|"associated with"| Dementia
    SLC30A8 -->|"interacts with"| Dementia
    COMT["COMT"]
    SLC30A8 -->|"associated with"| COMT
    NBEA["NBEA"]
    SLC30A8 -->|"associated with"| NBEA
    HTR2C["HTR2C"]
    SLC30A8 -->|"associated with"| HTR2C
    ADRA2A["ADRA2A"]
    SLC30A8 -->|"associated with"| ADRA2A
    BCHE["BCHE"]
    SLC30A8 -->|"associated with"| BCHE
    SLC6A2["SLC6A2"]
    SLC30A8 -->|"associated with"| SLC6A2
    MAOB["MAOB"]
    MAOB -->|"associated with"| SLC30A8
    GABRA1["GABRA1"]
    GABRA1 -->|"associated with"| SLC30A8
    CHAT["CHAT"]
    CHAT -->|"associated with"| SLC30A8
    CYP2D6["CYP2D6"]
    CYP2D6 -->|"associated with"| SLC30A8
    APOE["APOE"]
    APOE -->|"associated with"| SLC30A8
    HMGCR["HMGCR"]
    HMGCR -->|"associated with"| SLC30A8
    OPRM1["OPRM1"]
    OPRM1 -->|"associated with"| SLC30A8
    BCHE -->|"associated with"| SLC30A8
    ADRA2A -->|"associated with"| SLC30A8
    ADRB2["ADRB2"]
    ADRB2 -->|"associated with"| SLC30A8
    GSTP1["GSTP1"]
    GSTP1 -->|"associated with"| SLC30A8
    ABCB1["ABCB1"]
    ABCB1 -->|"associated with"| SLC30A8
    style SLC30A8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (49)

TargetRelationTypeStr
Alzheimerassociated_withdisease0.65
Dementiatherapeutic_targetdisease0.65
Depressionassociated_withdisease0.65
Anxietyassociated_withdisease0.65
Dementiaassociated_withdisease0.65

Incoming (33)

SourceRelationTypeStr
ADRA2Aassociated_withgene0.70
MAOBassociated_withgene0.60
GABRA1associated_withgene0.60
CHATassociated_withgene0.60
CYP2D6associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found