Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAOB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MAOB is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with Als, Alzheimer, Anxiety. Connected to 71 entities in the SciDEX knowledge graph.
| Gene Symbol | MAOB |
| Full Name | Monoamine Oxidase B |
| Chromosome | Xp11.23 |
| Protein Family | Monoamine oxidase family |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | platelets and in the mitochondrial outer membrane of serotonergic and dopaminergic neurons |
| Molecular Weight | 58.7 kDa |
| Pathways | autophagy pathway |
| UniProt ID | P50395 |
| NCBI Gene ID | 4129 |
| Ensembl ID | ENSG00000105707 |
| OMIM | 309860 |
| GeneCards | MAOB |
| Human Protein Atlas | MAOB |
| Associated Diseases | Als, Alzheimer, Alzheimer'S Disease, Anxiety, Dementia |
| Interactions | IL1B, CASP3, APP, GSK3B, TNF, MICRORNAS |
| KG Connections | 161 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
MAOB["MAOB"] -->|"associated with"| Alzheimer["Alzheimer"]
MAOB["MAOB"] -->|"therapeutic target"| Dementia["Dementia"]
MAOB["MAOB"] -->|"associated with"| Depression["Depression"]
MAOB["MAOB"] -->|"associated with"| Anxiety["Anxiety"]
MAOB["MAOB"] -->|"associated with"| Dementia["Dementia"]
MAOB["MAOB"] -->|"activates"| Cardiovascular["Cardiovascular"]
MAOB["MAOB"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
MAOB["MAOB"] -->|"associated with"| Als["Als"]
MAOB["MAOB"] -->|"activates"| Hypertension["Hypertension"]
MAOB["MAOB"] -->|"activates"| Ms["Ms"]
MAOB["MAOB"] -->|"interacts with"| Dementia["Dementia"]
MAOB["MAOB"] -->|"associated with"| GABRA1["GABRA1"]
style MAOB fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
style Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
style Depression fill:#ef5350,stroke:#333,color:#e0e0e0
style Anxiety fill:#ef5350,stroke:#333,color:#e0e0e0
style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
style Als fill:#ef5350,stroke:#333,color:#e0e0e0
style Hypertension fill:#ef5350,stroke:#333,color:#e0e0e0
style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
style GABRA1 fill:#4a1a6b,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-6784494f1741 | provides_data_for | dataset | 1.00 |
| depression | modulates | phenotype | 0.75 |
| Alzheimer | associated_with | disease | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Anxiety | associated_with | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| Cardiovascular | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Hypertension | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Neuroinflammation | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Neurodegeneration | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| GABRA1 | associated_with | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| CYP2D6 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| SLC30A8 | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| NBEA | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| ADRA2A | associated_with | gene | 0.60 |
| BCHE | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| GSTP1 | associated_with | gene | 0.60 |
| CYP3A4 | associated_with | gene | 0.60 |
| ABCG2 | associated_with | gene | 0.60 |
| ADRB2 | associated_with | gene | 0.60 |
| TNF | therapeutic_target | gene | 0.60 |
| BAX | therapeutic_target | gene | 0.60 |
| IL1A | therapeutic_target | gene | 0.60 |
| IL1B | interacts_with | gene | 0.60 |
| CASP3 | interacts_with | gene | 0.60 |
| APP | interacts_with | gene | 0.60 |
| GSK3B | interacts_with | gene | 0.60 |
| AKT1 | therapeutic_target | gene | 0.60 |
| AKT1 | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-6784494f1741 | data_in | dataset | 1.00 |
| BCHE | associated_with | gene | 0.60 |
| ADRA2A | associated_with | gene | 0.60 |
| ADRB2 | associated_with | gene | 0.60 |
| GSTP1 | associated_with | gene | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| ABCG2 | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| EGR1 | associated_with | gene | 0.60 |
| SP1 | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| SLC30A8 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| NBEA | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| CYP2D6 | associated_with | gene | 0.60 |
| CYP3A4 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| MAOA | interacts_with | gene | 0.60 |
| APP | interacts_with | gene | 0.60 |
| BDNF | therapeutic_target | gene | 0.60 |
| GFAP | therapeutic_target | gene | 0.60 |
| BAX | therapeutic_target | gene | 0.60 |
| IL1B | interacts_with | gene | 0.60 |
| GSK3B | interacts_with | gene | 0.60 |
| IL1A | therapeutic_target | gene | 0.60 |
| BCL2 | interacts_with | gene | 0.60 |
| CASP3 | interacts_with | gene | 0.60 |
| HMOX1 | therapeutic_target | gene | 0.60 |
| MAOA | therapeutic_target | gene | 0.60 |
| PTGS2 | therapeutic_target | gene | 0.60 |
| NFE2L2 | therapeutic_target | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| TNF | therapeutic_target | gene | 0.60 |
| AKT1 | therapeutic_target | gene | 0.60 |
| AKT1 | targets | gene | 0.60 |
| CYP2C19 | associated_with | gene | 0.60 |
| CYP1A2 | associated_with | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| PER | interacts_with | gene | 0.60 |
| CYP2E1 | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| ANXIETY | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||