gene

RAPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

113Connections
0Hypotheses
0Analyses
50Outgoing
35Incoming

Summary

RAPTOR is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, regulates. Associated with Als, Cancer, Carcinoma. Connected to 67 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRAPTOR
Full NameRegulatory Associated Protein of mTORC1
AliasesRaptor protein
Chromosome17q1.32
FunctionRAPTOR (Regulatory-Associated Protein of mTOR) is an essential component of mTOR Complex 1 (mTORC1), serving as a scaffolding protein that recruits substrates to the mTOR kinase.
Primary Expressionthe nervous system: - High expression: Cerebral cortex, hippocampus, basal forebrain - Mo
Molecular Weight149 kDa
Pathwaysmtor, mTOR, PI3K, AMPK
UniProt IDQ8N122
Ensembl IDENSG00000141551
GeneCardsRAPTOR
Human Protein AtlasRAPTOR
Associated Diseasesneurodegeneration
InteractionsSNCA, ATG5, RHEB, MTOR, Rb, TBK1
KG Connections111 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: RAPTOR — AlphaFold Q8N122 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RAPTOR Gene

gene · 547 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

rapamycin-tauopathy

therapeutic · 3805 words

RICTOR Protein

protein · 3451 words

RRAGB — Ras-Related GTP Binding B

gene · 2988 words

mTOR Signaling in Neurodegeneration

mechanism · 2950 words

Pathway Diagram

graph TD
    RAPTOR["<b>RAPTOR</b>"]
    axonal_regeneration(["axonal regeneration"])
    RAPTOR -->|"regulates"| axonal_regeneration
    mTORC1["mTORC1"]
    RAPTOR -->|"interacts with"| mTORC1
    Ms{"Ms"}
    RAPTOR -->|"activates"| Ms
    Parkinson{"Parkinson"}
    RAPTOR -->|"activates"| Parkinson
    Hepatitis{"Hepatitis"}
    RAPTOR -->|"expressed in"| Hepatitis
    Cancer{"Cancer"}
    RAPTOR -->|"expressed in"| Cancer
    Carcinoma{"Carcinoma"}
    RAPTOR -->|"expressed in"| Carcinoma
    Cirrhosis{"Cirrhosis"}
    RAPTOR -->|"expressed in"| Cirrhosis
    RAPTOR -->|"expressed in"| Ms
    Tumor{"Tumor"}
    RAPTOR -->|"regulates"| Tumor
    RAPTOR -->|"inhibits"| Cancer
    RAPTOR -->|"inhibits"| Tumor
    AMPK["AMPK"]
    AMPK -->|"activates"| RAPTOR
    SNCA["SNCA"]
    SNCA -->|"activates"| RAPTOR
    MTOR["MTOR"]
    MTOR -->|"regulates"| RAPTOR
    P62["P62"]
    P62 -->|"regulates"| RAPTOR
    ULK1["ULK1"]
    ULK1 -->|"regulates"| RAPTOR
    CANCER["CANCER"]
    CANCER -->|"expressed in"| RAPTOR
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"regulates"| RAPTOR
    MTOR -->|"inhibits"| RAPTOR
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"inhibits"| RAPTOR
    MTORC1["MTORC1"]
    MTORC1 -->|"inhibits"| RAPTOR
    CANCER -->|"inhibits"| RAPTOR
    AUTOPHAGY -->|"inhibits"| RAPTOR
    style RAPTOR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (77)

TargetRelationTypeStr
axonal regenerationregulatesprocess0.70
mTORC1interacts_withprotein0.70
Msactivatesdisease0.65
Parkinsonactivatesdisease0.65
Hepatitisexpressed_indisease0.65

Incoming (36)

SourceRelationTypeStr
SNCAactivatesgene0.60
MTORregulatesgene0.60
P62regulatesgene0.60
ULK1regulatesgene0.60
MTORinhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found