gene

PRKCA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKCA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

29Outgoing

12Incoming

Summary

Protein Kinase C Alpha - key signaling kinase involved in synaptic plasticity, apoptosis, and neurodegenerative disease mechanisms

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🧬 Gene Info

Gene Symbol	PRKCA
Full Name	Protein Kinase C Alpha
Chromosome	17q24.2
Protein Family	PKC family, AGC kinase group
Protein Type	Kinase
Function	is a member of the protein kinase C family of serine/threonine kinases [1](https://pubmed.
Molecular Weight	76.8 kDa
Amino Acids	672 aa
Exons	17
Pathways	NF-κB
UniProt ID	P17252
NCBI Gene ID	5578
GeneCards	PRKCA
Human Protein Atlas	PRKCA
Disease Relevance	Alzheimer's Disease, Parkinson's Disease, Schizophrenia, Cancer
Associated Diseases	neurodegeneration
Interactions	AKT, TNF
KG Connections	41 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRKCA — AlphaFold P17252 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRKCA["<b>PRKCA</b>"]
    TNF["TNF"]
    PRKCA -->|"activates"| TNF
    neurodegeneration["neurodegeneration"]
    PRKCA -->|"implicated in"| neurodegeneration
    NFE2L2["NFE2L2"]
    NFE2L2 -->|"therapeutic target"| PRKCA
    TGFB1["TGFB1"]
    TGFB1 -->|"therapeutic target"| PRKCA
    PPARA["PPARA"]
    PPARA -->|"therapeutic target"| PRKCA
    GSTP1["GSTP1"]
    GSTP1 -->|"therapeutic target"| PRKCA
    SREBF1["SREBF1"]
    SREBF1 -->|"therapeutic target"| PRKCA
    TNF -->|"therapeutic target"| PRKCA
    CAT["CAT"]
    CAT -->|"therapeutic target"| PRKCA
    IL4["IL4"]
    IL4 -->|"therapeutic target"| PRKCA
    PTEN["PTEN"]
    PTEN -->|"therapeutic target"| PRKCA
    AMPK["AMPK"]
    AMPK -->|"therapeutic target"| PRKCA
    style PRKCA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
AKT	activates	protein	0.80
TNF	activates	protein	0.70
Parkinson's Disease	regulates	disease	0.70
Ms	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
EGFR	therapeutic_target	gene	0.60
ARG1	therapeutic_target	gene	0.60
NOS3	therapeutic_target	gene	0.60
GAD2	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
STAT3	therapeutic_target	gene	0.60
MAPK8	therapeutic_target	gene	0.60
NFKB1	regulates	gene	0.60
TNF	regulates	gene	0.60
AKT1	regulates	gene	0.60
RELA	regulates	gene	0.60
TP53	regulates	gene	0.60
APP	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ACHE	therapeutic_target	gene	0.60
Lipid Metabolism	therapeutic_target	pathway	0.60
Synaptic Plasticity	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
APP/PS1	therapeutic_target	gene	0.60
Sphingolipid	regulates	pathway	0.60
Akt	regulates	pathway	0.60

Incoming (12)

Source	Relation	Type	Str
NFE2L2	therapeutic_target	gene	0.60
TGFB1	therapeutic_target	gene	0.60
PPARA	therapeutic_target	gene	0.60
GSTP1	therapeutic_target	gene	0.60
SREBF1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
CAT	therapeutic_target	gene	0.60
IL4	therapeutic_target	gene	0.60
PTEN	therapeutic_target	gene	0.60
PPARG	therapeutic_target	gene	0.60
MAOA	therapeutic_target	gene	0.60
AMPK	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PRKCA

Understanding Entity Pages

Summary

Wiki Pages (12)

PRKCA — Protein Kinase C Alpha

PICK1 - Protein Interacting With C Kinase 1

PRKCG — Protein Kinase C Gamma

Protein Kinase C Signaling Pathway

PRKCA Gene

Protein Kinase C (PKC) Signaling in Parkinson's Disease

PLCB4 — Phospholipase C Beta 4

PRKCA Protein (Protein Kinase C Alpha)

SCN3B Protein (Sodium Voltage-Gated Channel Beta Subunit 3)

Alpha-1 Adrenergic Neurons