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gene

EED

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EED: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

125Connections
30Hypotheses
0Analyses
50Outgoing
50Incoming
2Experiments
0Debates

Summary

EED is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, interacts with. Associated with Als, Cancer, Inflammation. Connected to 23 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolEED
Full NameEmbryonic Ectoderm Development
Chromosome11q14.2
Functionencodes a core scaffolding subunit of Polycomb Repressive Complex 2 (PRC2), the multisubunit complex responsible for trimethylation of histone H3 at lysine 27 (H3K27me3).
PathwaysMapk, Microrna, Nf-Kb, Wnt
UniProt IDO75530
Ensembl IDENSG00000074266
OMIM605984
GeneCardsEED
Human Protein AtlasEED
Associated Diseasesneurodegeneration
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, Aβ, COMPLEMENT
KG Connections125 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: EED — AlphaFold O75530 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EED

gene · 1034 words
→

Pathway Diagram

graph TD
    EED["EED (gene)"]
    EZH2["EZH2"]
    PRC2["PRC2 Complex"]
    TNF["TNF-alpha"]
    IL6["IL-6"]
    NFKB["NF-kappaB Pathway"]
    PI3K["PI3K/AKT"]
    MAPK["MAPK Pathway"]
    WNT["Wnt Pathway"]
    CTNNB1["beta-catenin"]
    INFLAMMATION["Neuroinflammation"]
    ALS["ALS"]
    MICRORNAS["miRNAs"]
    NEURODEGENERATION["Neurodegeneration"]

    EZH2 -->|"forms complex"| PRC2
    EED -->|"core component"| PRC2
    PRC2 -->|"H3K27me3"| NEURODEGENERATION

    TNF -->|"upregulates"| EED
    IL6 -->|"upregulates"| EED
    INFLAMMATION -->|"activates"| EED
    EED -->|"promotes"| INFLAMMATION

    EED -->|"regulates"| NFKB
    NFKB -->|"feedback"| EED
    PI3K -->|"modulates"| EED
    EED -->|"controls"| MAPK

    EED -->|"suppresses"| WNT
    WNT -->|"regulates"| CTNNB1
    EED -->|"targets"| CTNNB1

    EED -->|"activates"| ALS
    MICRORNAS -->|"therapeutic target"| EED

    EED -->|"drives"| NEURODEGENERATION

    style EED fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
    style MICRORNAS fill:#1b5e20,stroke:#4caf50
    style INFLAMMATION fill:#ef5350,stroke:#d32f2f
    style ALS fill:#7d4200,stroke:#f57c00
    style NEURODEGENERATION fill:#7d4200,stroke:#f57c00
    style PRC2 fill:#4a1a6b,stroke:#9c27b0
    style NFKB fill:#4a1a6b,stroke:#9c27b0

Outgoing (70)

TargetRelationTypeStr
oxidative stress responseparticipates_inpathway0.70
Alzheimeractivatesdisease0.65
Inflammationactivatesdisease0.65
Alsactivatesdisease0.65
Cancerregulatesdisease0.65

Incoming (55)

SourceRelationTypeStr
ALZHEIMER DISEASEassociated_withgene0.80
LRP1activatesgene0.60
SPI1associated_withgene0.60
TMEM106Bassociated_withgene0.60
PICALMassociated_withgene0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Closed-loop focused ultrasound targeting EC-II PV interneuro 0.863 alzheimers Circuit-level neural dynamics in neurode
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec 0.843 neurodegeneration How do different microglial subtypes (DA
MAPT tau seeding and release across AD, FTD, and PD-spectrum 0.812 multi Cross-disease neurodegeneration mechanis
Thalamocortical Feedforward Inhibition Imposes Rhythm on Gly 0.808 neuroscience GluN2B-Mediated Thalamocortical Control
Closed-loop transcranial focused ultrasound targeting CA1 PV 0.797 alzheimers Circuit-level neural dynamics in neurode
Repeat-domain exposure defines seed-competent tau conformers 0.760 neurodegeneration Seed-competent tau conformers in trans-s
H3: G3BP1 as Nucleation Hub for TDP-43/FUS Seeding 0.743 neurodegeneration How do pathological stress granules tran
Tau missorting transitions into an autonomous tau-seeding st 0.740 neurodegeneration Does tau dendritic missorting persist in
Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-002 0.733 molecular-neurobiology How does lncRNA-0021 achieve sequence-sp
Glucosylceramide Accumulation from GCase Deficiency Disrupts 0.700 neurodegeneration -
Cross-Seeding Prevention Strategy 0.689 neurodegeneration RNA binding protein dysregulation across
TREM2 R47H variant synergizes with APOE4 to collapse microgl 0.681 neuroscience APOE4-driven lipid metabolism dysregulat
Seed match plus local RNA structure jointly determine lncRNA 0.670 molecular-neurobiology How does lncRNA-0021 achieve sequence-sp
C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward 0.651 neuroinflammation What molecular mechanisms determine whet
Autophagic Flux Enhancement Synergizes With Chaperones to Cl 0.649 protein-folding Can chaperone enhancement approaches ove
Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro 0.642 neurodegeneration What are the mechanisms by which gut mic
H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seed 0.640 neurodegeneration Entorhinal cortex layer II vulnerability
Chaperone-Degradation Coupling Prevents Aggregate Persistenc 0.632 protein-folding Can chaperone enhancement approaches ove
CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracell 0.630 neurodegeneration Investigate prion-like spreading of tau
Tau Cross-Seeding and Interaction 0.610 neurodegeneration What mechanisms underlie TDP-43's contri
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation 0.601 neuroinflammation What molecular mechanisms drive the tran
A post-trigger CDK5-dominant kinase feedback loop maintains 0.590 neurodegeneration Does tau dendritic missorting persist in
Peri-plaque tau seeding restraint via TREM2-competent microg 0.590 neurodegeneration Does the cancer-cystatin-C-TREM2 pathway
APOE4 drives astrocyte metabolic reprogramming toward glycol 0.580 neuroscience APOE4-driven lipid metabolism dysregulat
NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitopha 0.578 neurodegeneration How do different organelle-specific auto
Real-time closed-loop transcranial focused ultrasound target 0.559 alzheimers Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with real-time g 0.546 alzheimers Circuit-level neural dynamics in neurode
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor 0.544 neurodegeneration Protein aggregation cross-seeding across
Cross-Seeding: Gut Microbiome-Derived Bacterial Curli and Fu 0.540 neurodegeneration How does gut microbiome dysbiosis contri
Transient Chaperone Priming Prior to Seed Inoculation Preven 0.535 protein-folding Can chaperone enhancement approaches ove

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Epigenetic clocks association with brain aging patterns in older women exploratory cognitive impairment and demen 0.900 0.00 human patients proposed N/A
Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State in_vivo neurodegeneration 0.774 0.65 C57BL/6J LPS model (chronic i. proposed $58,000

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010] Albrechtsen HM, Saritas G, Winge SB, Mai J Clin Endocrinol Metab 2026 0
Epigenetics in chronic rhinosinusitis. [PMID:41442742] Kumar N, Brar T, Lal D Curr Opin Otolaryngol Head Nec 2026 0
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286] Jackson G, Islam H, de Souza Teixeira AA Life Sci 2026 0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] Mishra R, Gupta JK Curr Alzheimer Res 2026 0
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] Gu X, Sun F, Li Y, Yang S, Li Y Int J Biol Macromol 2026 0
Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323] Pavlović N, Todorović P, Maglica M, Kopi Int J Mol Sci 2026 0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] Mishra R, Gupta JK Current Alzheimer research 2026 0
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] Zhang D, Zhang W, Ming C, Gao X, Yuan H, Neuron 2024 0
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] Balusu S, De Strooper B Acta neuropathologica 2024 0
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] Burillo J, Marqués P, Jiménez B, Gonzále Cells 2021 0
LRRK2 Promotes Tau Accumulation, Aggregation and Release. [PMID:26014385] Unknown Molecular neurobiology 2017 0
Etiology and pathophysiology of frontotemporal dementia, Parkinson disease and A [PMID:18322368] Unknown Neuro-degenerative diseases 2008 0
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] ["Oakley, Holly", "Cole, Sarah L", "Loga The Journal of neuroscience : 2006 0
The role of tau (MAPT) in frontotemporal dementia and related tauopathies. [PMID:15365985] Unknown Human mutation 2005 0
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] ["Hardy, John", "Selkoe, Dennis J"] Science (New York, N.Y.) 2002 0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EED in their description or question text

Repeat-domain exposure defines seed-competent tau conformers

Score: 0.760 · neurodegeneration · 2026-04-26

Tau assemblies become seed-competent when their repeat-domain surfaces adopt a conformation that both survives transfer

H3: G3BP1 as Nucleation Hub for TDP-43/FUS Seeding

Score: 0.743 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The molecular basis of G3BP1-mediated nucleation centers on the dynamic interplay

Tau missorting transitions into an autonomous tau-seeding state after transient

Score: 0.740 · neurodegeneration · 2026-04-25

Transient Aβ exposure induces dendritic tau missorting that then converts into a locally self-propagating tau oligomer/s

Seed-Proximal Asymmetric Duplex Stability Confers lncRNA-0021/miR-6361 Binding S

Score: 0.733 · molecular-neurobiology · 2026-04-17

**Molecular Mechanism and Rationale** The lncRNA-0021/miR-6361 interaction represents a sophisticated regulatory mechan

Cross-Seeding Prevention Strategy

Score: 0.689 · neurodegeneration · 2026-04-02

## Mechanistic Overview Cross-Seeding Prevention Strategy starts from the claim that modulating TARDBP within the diseas

TREM2 R47H variant synergizes with APOE4 to collapse microglial lipid clearance

Score: 0.681 · neuroscience · 2026-04-22

## **Molecular Mechanism and Rationale** The proposed mechanism centers on a catastrophic convergence of lipid homeosta

Seed match plus local RNA structure jointly determine lncRNA-0021 binding to mmu

Score: 0.670 · molecular-neurobiology · 2026-04-25

The most likely explanation is a two-factor recognition mechanism: a canonical miRNA seed-complementary site in lncRNA-0

C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward Neurotoxic Loop

Score: 0.651 · neuroinflammation · 2026-04-14

## **Molecular Mechanism and Rationale** The complement cascade represents a critical immune surveillance system within

Autophagic Flux Enhancement Synergizes With Chaperones to Clear High-Molecular-W

Score: 0.649 · protein-folding · 2026-04-22

**Molecular Mechanism and Rationale** The proposed therapeutic strategy exploits the complementary relationship between

Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cross-Seeding

Score: 0.642 · neurodegeneration · 2026-04-02

## Mechanistic Overview Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cross-Seeding starts from the claim tha

H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seeding

Score: 0.640 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The mechanistic target of rapamycin complex 1 (mTORC1) serves as a critical cellu

Chaperone-Degradation Coupling Prevents Aggregate Persistence by Shunting Seeds

Score: 0.632 · protein-folding · 2026-04-22

**Molecular Mechanism and Rationale** The chaperone-degradation coupling hypothesis centers on the critical interaction

CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracellular Tau Seeds, Prev

Score: 0.630 · neurodegeneration · 2026-04-22

## Mechanistic Overview CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracellular Tau Seeds, Preventing Template-

Tau Cross-Seeding and Interaction

Score: 0.610 · neurodegeneration · 2026-04-21

## Mechanistic Overview Tau Cross-Seeding and Interaction starts from the claim that modulating MAPT within the disease

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