gene

LILRB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LILRB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

149Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for LILRB2 — Leukocyte Immunoglobulin-Like Receptor B2

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🧬 Gene Info

Gene Symbol	LILRB2
Full Name	Leukocyte Immunoglobulin-Like Receptor B2
Chromosome	19q13.42
Protein Type	Receptor
Function	encodes an inhibitory immunoreceptor on chromosome 19q13.
Primary Expression	Microglia, Macrophages, Monocytes, Dendritic cells, Osteoclasts
Amino Acids	598 aa
Exons	16
Pathways	Amyloid, Complement, Phagocytosis, Stem Cell
UniProt ID	Q8N423
NCBI Gene ID	10288
Ensembl ID	ENSG00000131042
OMIM	604815
GeneCards	LILRB2
Human Protein Atlas	LILRB2
Associated Diseases	Alzheimer's Disease, Parkinson's Disease
Interactions	TREM2, LRP1, TAU, CYTOKINES, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	149 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LILRB2 — AlphaFold Q8N423 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LILRB2["<b>LILRB2</b>"]
    Alzheimer{"Alzheimer"}
    LILRB2 -->|"inhibits"| Alzheimer
    Ms{"Ms"}
    LILRB2 -->|"inhibits"| Ms
    TREM2["TREM2"]
    LILRB2 -->|"inhibits"| TREM2
    Phagocytosis(["Phagocytosis"])
    LILRB2 -->|"activates"| Phagocytosis
    neurodegeneration["neurodegeneration"]
    LILRB2 -->|"implicated in"| neurodegeneration
    style LILRB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (82)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Alzheimer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
TREM2	inhibits	gene	0.60
PICALM	associated_with	entity	0.60
PLCG2	associated_with	entity	0.60
PSEN1	associated_with	entity	0.60
PTK2B	associated_with	entity	0.60
SORL1	associated_with	entity	0.60
SPI1	associated_with	entity	0.60
TMEM106B	associated_with	entity	0.60
TREM2	associated_with	entity	0.60
ACE	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
GRN	associated_with	gene	0.60
CLU	associated_with	gene	0.60
APP	associated_with	gene	0.60
ABI3	associated_with	gene	0.60
CD33	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
EED	associated_with	gene	0.60
CR1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CTSH	associated_with	gene	0.60
Rb	associated_with	protein	0.60
PICALM	implicated_in	gene	0.60
PLCG2	implicated_in	gene	0.60
PSEN1	implicated_in	gene	0.60
PTK2B	implicated_in	gene	0.60
SORL1	implicated_in	gene	0.60
SPI1	implicated_in	gene	0.60
TMEM106B	implicated_in	gene	0.60
TREM2	implicated_in	gene	0.60
phagocytosis	implicated_in	process	0.60
SIGLEC11	implicated_in	gene	0.60
TREM2	expressed_in	gene	0.60
Phagocytosis	activates	pathway	0.60
CYTOKINES	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
MICROGLIA	inhibits	gene	0.60
Stem Cell	activates	pathway	0.60
PHAGOCYTOSIS	associated_with	entity	0.60

Incoming (67)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
TREM2	inhibits	gene	0.60
ABCA1	associated_with	entity	0.60
ABI3	associated_with	entity	0.60
ADAM17	associated_with	entity	0.60
APOE	associated_with	entity	0.60
APP	associated_with	entity	0.60
BIN1	associated_with	entity	0.60
CD2AP	associated_with	entity	0.60
CD33	associated_with	entity	0.60
CR1	associated_with	entity	0.60
CTSB	associated_with	entity	0.60
CTSH	associated_with	entity	0.60
EED	associated_with	entity	0.60
GRN	associated_with	entity	0.60
INPP5D	associated_with	entity	0.60
DAP12	inhibits	gene	0.60
PTK2B	associated_with	gene	0.60
CLU	associated_with	gene	0.60
SPI1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
LRP1	activates	gene	0.60
PSEN1	associated_with	gene	0.60
ACE	associated_with	gene	0.60
ABCA1	implicated_in	gene	0.60
ABI3	implicated_in	gene	0.60
ACE	implicated_in	gene	0.60
ADAM17	implicated_in	gene	0.60
APOE	implicated_in	gene	0.60
APP	implicated_in	gene	0.60
BIN1	implicated_in	gene	0.60
CD2AP	implicated_in	gene	0.60
CD33	implicated_in	gene	0.60
CLU	implicated_in	gene	0.60
CR1	implicated_in	gene	0.60
CTSB	implicated_in	gene	0.60
CTSH	implicated_in	gene	0.60
EED	implicated_in	gene	0.60
GRN	implicated_in	gene	0.60
INPP5D	implicated_in	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AND	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
CYTOKINES	activates	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
APOE	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LILRB2

Understanding Entity Pages

Summary

Wiki Pages (7)

LILRB2 — Leukocyte Immunoglobulin-Like Receptor B2

Alzheimer's Disease

Synaptic Loss in Alzheimer's Disease Pathway

Synaptic Transmission

renin-angiotensin-system