pathway

Tgf-Β Signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Tgf-Β Signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

91Connections

0Hypotheses

1Analyses

3Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

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🔀 Pathway Info

Name	Tgf-Β Signaling
Key Genes/Proteins	AGING, AKT, ALS, AMPK, AMYOTROPHIC LATERAL SCLEROSIS, AUTOPHAGY
Related Diseases	Aging, Als, Amyotrophic Lateral Sclerosis, Breast Cancer, cancer

Pathway Diagram

graph TD
    TGF___SIGNALING["TGF-Beta SIGNALING"]
    CYTOKINES["CYTOKINES"] -->|"inhibits"| TGF___SIGNALING
    Tumor["Tumor"] -->|"activates"| TGF___SIGNALING
    Als["Als"] -->|"activates"| TGF___SIGNALING
    CANCER["CANCER"] -->|"activates"| TGF___SIGNALING
    Cancer["Cancer"] -->|"activates"| TGF___SIGNALING
    Carcinoma["Carcinoma"] -->|"activates"| TGF___SIGNALING
    INFLAMMATION["INFLAMMATION"] -->|"target for"| TGF___SIGNALING
    Inflammation["Inflammation"] -->|"target for"| TGF___SIGNALING
    MTOR["MTOR"] -->|"target for"| TGF___SIGNALING
    HUNTINGTON["HUNTINGTON"] -->|"implicated in"| TGF___SIGNALING

Outgoing (3)

Target	Relation	Type	Str
tissue remodeling	promotes	process	0.90
Cancer Metastasis	associated_with	disease	0.85
Alzheimer's_disease	decreases_risk	disease	0.70

Incoming (88)

Source	Relation	Type	Str
necroinflammation	associated_with	process	0.85
HTLV-1	activates	entity	0.80
CANCER	activates	gene	0.70
Cancer	activates	disease	0.70
INFLAMMATION	therapeutic_target	gene	0.70
CYTOKINES	inhibits	gene	0.70
Tumor	activates	disease	0.70
Inflammation	therapeutic_target	disease	0.70
SMAD7	inhibits	protein	0.70
Carcinoma	activates	disease	0.70
Als	activates	disease	0.70
ALS	activates	gene	0.60
GENES	implicated_in	gene	0.60
HUNTINGTON'S DISEASE	implicated_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	implicated_in	gene	0.60
Huntington	implicated_in	disease	0.60
Multiple Sclerosis	implicated_in	disease	0.60
Amyotrophic Lateral Sclerosis	implicated_in	disease	0.60
AMPK	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
CANCER	associated_with	gene	0.60
MTOR	activates	gene	0.60
Cancer	associated_with	disease	0.60
HUNTINGTON	implicated_in	gene	0.60
Hepatocellular Carcinoma	activates	disease	0.60
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.60
Lung Cancer	activates	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
SMAD7	regulates	gene	0.60
SMAD2	regulates	gene	0.60
SMAD3	regulates	gene	0.60
CANCER	regulates	gene	0.60
OVERVIEW	regulates	gene	0.60
Tumor	regulates	disease	0.60
Fibrosis	regulates	disease	0.60
Cancer	regulates	disease	0.60
Als	regulates	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Cardiac	regulates	disease	0.60
Breast Cancer	activates	disease	0.60
MIRNAS	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
NF-ΚB	associated_with	gene	0.60
P53	associated_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
AKT	associated_with	gene	0.60
P21	associated_with	gene	0.60
Inflammation	regulates	disease	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What specific astrocyte-derived factors can 'erase' pathological microglial memo

neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.712

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The astrocyte-mediated hypothesis proposes memory erasure but provides no molecu

closed · Rounds: 4 · Score: 0.65 · 2026-04-21

Related Research

Hypotheses and analyses mentioning Tgf-Β Signaling in their description or question text

No additional research found