disease

Hypertension

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Hypertension: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1059Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Hypertension is a disease characterized by neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 649 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	LRP8, LRP5, LRP1, LRP2, LRP1B, LRP4, PAH, LDLR
KG Connections	988 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Hypertension["Hypertension"] -->|"associated"| Lipid_Metabolism["Lipid Metabolism"]
    Hypertension["Hypertension"] -->|"associated"| Wnt["Wnt"]
    Hypertension["Hypertension"] -->|"contributes to"| Oxidative_Stress["Oxidative Stress"]
    Hypertension["Hypertension"] -->|"therapeutic target"| Pi3K["Pi3K"]
    Hypertension["Hypertension"] -->|"protects against"| Oxidative_Stress_1["Oxidative Stress"]
    Hypertension["Hypertension"] -->|"associated"| Angiogenesis["Angiogenesis"]
    Short_Chain_Fatty_Acids["Short-Chain Fatty Acids"] -->|"risk factor for"| Hypertension["Hypertension"]
    PIEZO1["PIEZO1"] -->|"activates"| Hypertension["Hypertension"]
    KCNK2["KCNK2"] -->|"activates"| Hypertension["Hypertension"]
    TRPC1["TRPC1"] -->|"activates"| Hypertension["Hypertension"]
    style Hypertension fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (385)

Target	Relation	Type	Str
Als	associated_with	disease	1.00
Cardiovascular	associated_with	disease	1.00
Heart Failure	associated_with	disease	1.00
Metabolic Syndrome	associated_with	disease	1.00
Als	activates	disease	1.00
Obesity	associated_with	disease	1.00
Insulin Resistance	associated_with	disease	1.00
Inflammation	activates	disease	1.00
Als	therapeutic_target	disease	1.00
Cardiac	associated_with	disease	0.95
Inflammation	associated_with	disease	0.95
Heart Failure	activates	disease	0.95
Inflammation	therapeutic_target	disease	0.95
Vascular Remodelling	associated_with	process	0.95
Arteriolosclerosis	risk_factor_for	disease	0.90
Cardiovascular Disease	risk_factor_for	disease	0.90
Arteriolosclerosis	causes	disease	0.88
Atherosclerosis	associated_with	disease	0.85
Aging	associated_with	disease	0.85
Cardiac	activates	disease	0.85
Als	implicated_in	disease	0.85
Stroke	associated_with	disease	0.85
Gene Expression	modulates	process	0.85
Alzheimer's Disease	risk_factor_for	disease	0.80
Cerebral Hypoperfusion	causes	mechanism	0.80
Oxidative Stress	activates	pathway	0.80
Autophagy	activates	pathway	0.80
Oxidative Stress	therapeutic_target	pathway	0.80
Apoptosis	implicated_in	pathway	0.80
Neurofilament Light	associated_with	biomarker	0.79
Glial Fibrillary Acidic Protein	associated_with	biomarker	0.79
White Matter Hyperintensity	causes	phenotype	0.78
Aging	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
Als	inhibits	disease	0.75
Als	treats	disease	0.75
Coronary Artery Disease	associated_with	disease	0.75
Heart Failure	therapeutic_target	disease	0.75
Alzheimer	therapeutic_target	disease	0.75
Cancer	associated_with	disease	0.75
Heart Failure	implicated_in	disease	0.75
Plasma Biomarker Changes	associated_with	process	0.75
Oxidative Stress	contributes_to	pathway	0.70
Blood-Brain Barrier	therapeutic_target	pathway	0.70
Epigenetic	therapeutic_target	pathway	0.70
Cerebral Perfusion	inhibits	process	0.70
Autophagy	associated_with	pathway	0.70
Oxidative Stress	causes	pathway	0.70
Cholesterol	associated_with	pathway	0.70
Cholesterol	activates	pathway	0.70

Incoming (674)

Source	Relation	Type	Str
Cardiovascular	associated_with	disease	1.00
Diabetes	associated_with	disease	1.00
INFLAMMATION	activates	gene	1.00
STROKE	associated_with	gene	1.00
INSULIN RESISTANCE	associated_with	gene	1.00
DIABETES MELLITUS	associated_with	gene	1.00
PAH	associated_with	gene	0.95
OXIDATIVE STRESS	therapeutic_target	gene	0.95
DIABETES MELLITUS	causes	gene	0.95
OXIDATIVE STRESS	activates	gene	0.95
INFLAMMATION	associated_with	gene	0.95
Endothelial Cell Senescence	associated_with	process	0.90
AMPK	activates	gene	0.85
NEURODEGENERATION	inhibits	gene	0.85
OXIDATIVE STRESS	regulates	gene	0.85
NEUROINFLAMMATION	therapeutic_target	gene	0.85
INFLAMMATION	contributes_to	gene	0.85
CANCER	associated_with	gene	0.85
NEURODEGENERATION	associated_with	gene	0.85
AGING	associated_with	gene	0.85
CYTOKINES	activates	gene	0.85
INFLAMMATION	causes	gene	0.85
GENES	associated_with	gene	0.85
ALZHEIMER	associated_with	gene	0.85
Short-Chain Fatty Acids	risk_factor_for	compound	0.85
Microglia Activation	associated_with	process	0.85
Microglia	involved_in	cell_type	0.85
AUTOPHAGY	activates	gene	0.85
AGING	activates	gene	0.85
Diabetes	activates	disease	0.85
NEURODEGENERATION	activates	gene	0.85
CYTOKINES	causes	gene	0.85
ALZHEIMER	therapeutic_target	gene	0.85
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.85
Cardiovascular	implicated_in	disease	0.85
INFLAMMATION	therapeutic_target	gene	0.85
APOPTOSIS	implicated_in	gene	0.85
Oxidative Stress	contributes_to	process	0.85
Alcohol Consumption	risk_factor_for	phenotype	0.85
BDNF	associated_with	gene	0.85
Neuroinflammation	contributes_to	process	0.85
20-HETE	causes	entity	0.80
SCFA	associated_with	chemical	0.80
Ion Channel Dysfunction	associated_with	mechanism	0.80
Microglia	regulates	cell_type	0.80
HCRT	associated_with	gene	0.80
Autonomic Nervous System Dysfunction	contributes_to	phenotype	0.78
STAT3	activates	gene	0.75
BAX	inhibits	gene	0.75
GENES	activates	gene	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Hypertension

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Clinical Management Guide for CBS/PSP

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

nimodipine-als

Alzheimer's Disease

coq10-neurodegeneration

williams-syndrome

rasagiline

APOC4 — Apolipoprotein C-IV

Vascular Cognitive Impairment (VCI)

VEGF/Angiogenesis Pathway in Neurodegeneration

Coenzyme Q10 for Neurodegeneration

blood-brain-barrier

nf1-protein

Niemann-Pick Disease Type C (NPC)

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers